The yak genome and adaptation to life at high altitude
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The yak genome and adaptation to life at high altitude. / Qiu, Qiang; Zhang, Guojie; Ma, Tao; Qian, Wubin; Wang, Junyi; Ye, Zhiqiang; Cao, Changchang; Hu, Quanjun; Kim, Jaebum; Larkin, Denis M; Auvil, Loretta; Capitanu, Boris; Ma, Jian; Lewin, Harris A; Qian, Xiaoju; Lang, Yongshan; Zhou, Ran; Wang, Lizhong; Wang, Kun; Xia, Jinquan; Liao, Shengguang; Pan, Shengkai; Lu, Xu; Hou, Haolong; Wang, Yan; Zang, Xuetao; Yin, Ye; Ma, Hui; Zhang, Jian; Wang, Zhaofeng; Zhang, Yingmei; Zhang, Dawei; Yonezawa, Takahiro; Hasegawa, Masami; Zhong, Yang; Liu, Wenbin; Zhang, Yan; Huang, Zhiyong; Zhang, Shengxiang; Long, Ruijun; Yang, Huanming; Wang, Jian; Lenstra, Johannes A; Cooper, David N; Wu, Yi; Wang, Jun; Shi, Peng; Wang, Jian; Liu, Jianquan.
In: Nature Genetics, Vol. 44, No. 8, 2012, p. 946-951.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - The yak genome and adaptation to life at high altitude
AU - Qiu, Qiang
AU - Zhang, Guojie
AU - Ma, Tao
AU - Qian, Wubin
AU - Wang, Junyi
AU - Ye, Zhiqiang
AU - Cao, Changchang
AU - Hu, Quanjun
AU - Kim, Jaebum
AU - Larkin, Denis M
AU - Auvil, Loretta
AU - Capitanu, Boris
AU - Ma, Jian
AU - Lewin, Harris A
AU - Qian, Xiaoju
AU - Lang, Yongshan
AU - Zhou, Ran
AU - Wang, Lizhong
AU - Wang, Kun
AU - Xia, Jinquan
AU - Liao, Shengguang
AU - Pan, Shengkai
AU - Lu, Xu
AU - Hou, Haolong
AU - Wang, Yan
AU - Zang, Xuetao
AU - Yin, Ye
AU - Ma, Hui
AU - Zhang, Jian
AU - Wang, Zhaofeng
AU - Zhang, Yingmei
AU - Zhang, Dawei
AU - Yonezawa, Takahiro
AU - Hasegawa, Masami
AU - Zhong, Yang
AU - Liu, Wenbin
AU - Zhang, Yan
AU - Huang, Zhiyong
AU - Zhang, Shengxiang
AU - Long, Ruijun
AU - Yang, Huanming
AU - Wang, Jian
AU - Lenstra, Johannes A
AU - Cooper, David N
AU - Wu, Yi
AU - Wang, Jun
AU - Shi, Peng
AU - Wang, Jian
AU - Liu, Jianquan
PY - 2012
Y1 - 2012
N2 - Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
AB - Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude. Here, we present the draft genome sequence of a female domestic yak generated using Illumina-based technology at 65-fold coverage. Genomic comparisons between yak and cattle identify an expansion in yak of gene families related to sensory perception and energy metabolism, as well as an enrichment of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans.
U2 - 10.1038/ng.2343
DO - 10.1038/ng.2343
M3 - Letter
C2 - 22751099
VL - 44
SP - 946
EP - 951
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -
ID: 44351702