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Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. / Arner, Erik; Daub, Carsten O.; Vitting-Seerup, Kristoffer; Andersson, Robin; Lilje, Berit; Drabløs, Finn; Lennartsson, Andreas; Rönnerblad, Michelle; Hrydziuszko, Olga; Vitezic, Morana; Freeman, Tom C; Alhendi, Ahmad M N; Arner, Peter; Axton, Richard; Baillie, J Kenneth; Beckhouse, Anthony; Bodega, Beatrice; Briggs, James; Brombacher, Frank; Davis, Margaret; Detmar, Michael; Ehrlund, Anna; Endoh, Mitsuhiro; Eslami, Afsaneh; Fagiolini, Michela; Fairbairn, Lynsey; Faulkner, Geoffrey J; Ferrai, Carmelo; Fisher, Malcolm E; Forrester, Lesley; Goldowitz, Daniel; Guler, Reto; Ha, Thomas; Hara, Mitsuko; Herlyn, Meenhard; Ikawa, Tomokatsu; Kai, Chieko; Kawamoto, Hiroshi; Khachigian, Levon M; Klinken, S Peter; Kojima, Soichi; Koseki, Haruhiko; Klein, Sarah; Mejhert, Niklas; Miyaguchi, Ken; Mizuno, Yosuke; Morimoto, Mitsuru; Morris, Kelly J; Mummery, Christine; Nakachi, Yutaka; Ogishima, Soichi; Okada-Hatakeyama, Mariko; Okazaki, Yasushi; Orlando, Valerio; Ovchinnikov, Dmitry; Passier, Robert; Patrikakis, Margaret; Pombo, Ana; Qin, Xian-Yang; Roy, Sugata; Sato, Hiroki; Savvi, Suzana; Saxena, Alka; Schwegmann, Anita; Sugiyama, Daisuke; Swoboda, Rolf; Tanaka, Hiroshi; Tomoiu, Andru; Winteringham, Louise N; Wolvetang, Ernst; Yanagi-Mizuochi, Chiyo; Yoneda, Misako; Zabierowski, Susan; Zhang, Peter; Abugessaisa, Imad; Bertin, Nicolas; Diehl, Alexander D; Fukuda, Shiro; Furuno, Masaaki; Harshbarger, Jayson; Hasegawa, Akira; Hori, Fumi; Ishikawa-Kato, Sachi; Ishizu, Yuri; Itoh, Masayoshi; Kawashima, Tsugumi; Kojima, Miki; Kondo, Naoto; Lizio, Marina; Meehan, Terrence F; Mungall, Christopher J; Murata, Mitsuyoshi; Nishiyori-Sueki, Hiromi; Sahin, Serkan; Nagao-Sato, Sayaka; Severin, Jessica; de Hoon, Michiel J L; Kawai, Jun; Kasukawa, Takeya; Lassmann, Timo; Suzuki, Harukazu; Kawaji, Hideya; Summers, Kim M; Wells, Christine; Hume, David A; Forrest, Alistair R R; Sandelin, Albin Gustav; Carninci, Piero; Hayashizaki, Yoshihide.
In:
Science (New York, N.Y.), Vol. 347, No. 6225, 2015, p. 1010-1014.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Arner, E, Daub, CO, Vitting-Seerup, K
, Andersson, R, Lilje, B, Drabløs, F, Lennartsson, A, Rönnerblad, M, Hrydziuszko, O, Vitezic, M, Freeman, TC, Alhendi, AMN, Arner, P, Axton, R, Baillie, JK, Beckhouse, A, Bodega, B, Briggs, J, Brombacher, F, Davis, M, Detmar, M, Ehrlund, A, Endoh, M, Eslami, A, Fagiolini, M, Fairbairn, L, Faulkner, GJ, Ferrai, C, Fisher, ME, Forrester, L, Goldowitz, D, Guler, R, Ha, T, Hara, M, Herlyn, M, Ikawa, T, Kai, C, Kawamoto, H, Khachigian, LM, Klinken, SP, Kojima, S, Koseki, H, Klein, S, Mejhert, N, Miyaguchi, K, Mizuno, Y, Morimoto, M, Morris, KJ, Mummery, C, Nakachi, Y, Ogishima, S, Okada-Hatakeyama, M, Okazaki, Y, Orlando, V, Ovchinnikov, D, Passier, R, Patrikakis, M, Pombo, A, Qin, X-Y, Roy, S, Sato, H, Savvi, S, Saxena, A, Schwegmann, A, Sugiyama, D, Swoboda, R, Tanaka, H, Tomoiu, A, Winteringham, LN, Wolvetang, E, Yanagi-Mizuochi, C, Yoneda, M, Zabierowski, S, Zhang, P, Abugessaisa, I, Bertin, N, Diehl, AD, Fukuda, S, Furuno, M, Harshbarger, J, Hasegawa, A, Hori, F, Ishikawa-Kato, S, Ishizu, Y, Itoh, M, Kawashima, T, Kojima, M, Kondo, N, Lizio, M, Meehan, TF, Mungall, CJ, Murata, M, Nishiyori-Sueki, H, Sahin, S, Nagao-Sato, S, Severin, J, de Hoon, MJL, Kawai, J, Kasukawa, T, Lassmann, T, Suzuki, H, Kawaji, H, Summers, KM, Wells, C, Hume, DA, Forrest, ARR
, Sandelin, AG, Carninci, P & Hayashizaki, Y 2015, '
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells',
Science (New York, N.Y.), vol. 347, no. 6225, pp. 1010-1014.
https://doi.org/10.1126/science.1259418
APA
Arner, E., Daub, C. O., Vitting-Seerup, K.
, Andersson, R., Lilje, B., Drabløs, F., Lennartsson, A., Rönnerblad, M., Hrydziuszko, O., Vitezic, M., Freeman, T. C., Alhendi, A. M. N., Arner, P., Axton, R., Baillie, J. K., Beckhouse, A., Bodega, B., Briggs, J., Brombacher, F., ... Hayashizaki, Y. (2015).
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Science (New York, N.Y.),
347(6225), 1010-1014.
https://doi.org/10.1126/science.1259418
Vancouver
Arner E, Daub CO, Vitting-Seerup K
, Andersson R, Lilje B, Drabløs F et al.
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.
Science (New York, N.Y.). 2015;347(6225):1010-1014.
https://doi.org/10.1126/science.1259418
Author
Arner, Erik ; Daub, Carsten O. ; Vitting-Seerup, Kristoffer ; Andersson, Robin ; Lilje, Berit ; Drabløs, Finn ; Lennartsson, Andreas ; Rönnerblad, Michelle ; Hrydziuszko, Olga ; Vitezic, Morana ; Freeman, Tom C ; Alhendi, Ahmad M N ; Arner, Peter ; Axton, Richard ; Baillie, J Kenneth ; Beckhouse, Anthony ; Bodega, Beatrice ; Briggs, James ; Brombacher, Frank ; Davis, Margaret ; Detmar, Michael ; Ehrlund, Anna ; Endoh, Mitsuhiro ; Eslami, Afsaneh ; Fagiolini, Michela ; Fairbairn, Lynsey ; Faulkner, Geoffrey J ; Ferrai, Carmelo ; Fisher, Malcolm E ; Forrester, Lesley ; Goldowitz, Daniel ; Guler, Reto ; Ha, Thomas ; Hara, Mitsuko ; Herlyn, Meenhard ; Ikawa, Tomokatsu ; Kai, Chieko ; Kawamoto, Hiroshi ; Khachigian, Levon M ; Klinken, S Peter ; Kojima, Soichi ; Koseki, Haruhiko ; Klein, Sarah ; Mejhert, Niklas ; Miyaguchi, Ken ; Mizuno, Yosuke ; Morimoto, Mitsuru ; Morris, Kelly J ; Mummery, Christine ; Nakachi, Yutaka ; Ogishima, Soichi ; Okada-Hatakeyama, Mariko ; Okazaki, Yasushi ; Orlando, Valerio ; Ovchinnikov, Dmitry ; Passier, Robert ; Patrikakis, Margaret ; Pombo, Ana ; Qin, Xian-Yang ; Roy, Sugata ; Sato, Hiroki ; Savvi, Suzana ; Saxena, Alka ; Schwegmann, Anita ; Sugiyama, Daisuke ; Swoboda, Rolf ; Tanaka, Hiroshi ; Tomoiu, Andru ; Winteringham, Louise N ; Wolvetang, Ernst ; Yanagi-Mizuochi, Chiyo ; Yoneda, Misako ; Zabierowski, Susan ; Zhang, Peter ; Abugessaisa, Imad ; Bertin, Nicolas ; Diehl, Alexander D ; Fukuda, Shiro ; Furuno, Masaaki ; Harshbarger, Jayson ; Hasegawa, Akira ; Hori, Fumi ; Ishikawa-Kato, Sachi ; Ishizu, Yuri ; Itoh, Masayoshi ; Kawashima, Tsugumi ; Kojima, Miki ; Kondo, Naoto ; Lizio, Marina ; Meehan, Terrence F ; Mungall, Christopher J ; Murata, Mitsuyoshi ; Nishiyori-Sueki, Hiromi ; Sahin, Serkan ; Nagao-Sato, Sayaka ; Severin, Jessica ; de Hoon, Michiel J L ; Kawai, Jun ; Kasukawa, Takeya ; Lassmann, Timo ; Suzuki, Harukazu ; Kawaji, Hideya ; Summers, Kim M ; Wells, Christine ; Hume, David A ; Forrest, Alistair R R ; Sandelin, Albin Gustav ; Carninci, Piero ; Hayashizaki, Yoshihide. / Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. In: Science (New York, N.Y.). 2015 ; Vol. 347, No. 6225. pp. 1010-1014.
Bibtex
@article{263b1da9800c47df88093ddf16ebd746,
title = "Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells",
abstract = "Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.",
author = "Erik Arner and Daub, {Carsten O.} and Kristoffer Vitting-Seerup and Robin Andersson and Berit Lilje and Finn Drabl{\o}s and Andreas Lennartsson and Michelle R{\"o}nnerblad and Olga Hrydziuszko and Morana Vitezic and Freeman, {Tom C} and Alhendi, {Ahmad M N} and Peter Arner and Richard Axton and Baillie, {J Kenneth} and Anthony Beckhouse and Beatrice Bodega and James Briggs and Frank Brombacher and Margaret Davis and Michael Detmar and Anna Ehrlund and Mitsuhiro Endoh and Afsaneh Eslami and Michela Fagiolini and Lynsey Fairbairn and Faulkner, {Geoffrey J} and Carmelo Ferrai and Fisher, {Malcolm E} and Lesley Forrester and Daniel Goldowitz and Reto Guler and Thomas Ha and Mitsuko Hara and Meenhard Herlyn and Tomokatsu Ikawa and Chieko Kai and Hiroshi Kawamoto and Khachigian, {Levon M} and Klinken, {S Peter} and Soichi Kojima and Haruhiko Koseki and Sarah Klein and Niklas Mejhert and Ken Miyaguchi and Yosuke Mizuno and Mitsuru Morimoto and Morris, {Kelly J} and Christine Mummery and Yutaka Nakachi and Soichi Ogishima and Mariko Okada-Hatakeyama and Yasushi Okazaki and Valerio Orlando and Dmitry Ovchinnikov and Robert Passier and Margaret Patrikakis and Ana Pombo and Xian-Yang Qin and Sugata Roy and Hiroki Sato and Suzana Savvi and Alka Saxena and Anita Schwegmann and Daisuke Sugiyama and Rolf Swoboda and Hiroshi Tanaka and Andru Tomoiu and Winteringham, {Louise N} and Ernst Wolvetang and Chiyo Yanagi-Mizuochi and Misako Yoneda and Susan Zabierowski and Peter Zhang and Imad Abugessaisa and Nicolas Bertin and Diehl, {Alexander D} and Shiro Fukuda and Masaaki Furuno and Jayson Harshbarger and Akira Hasegawa and Fumi Hori and Sachi Ishikawa-Kato and Yuri Ishizu and Masayoshi Itoh and Tsugumi Kawashima and Miki Kojima and Naoto Kondo and Marina Lizio and Meehan, {Terrence F} and Mungall, {Christopher J} and Mitsuyoshi Murata and Hiromi Nishiyori-Sueki and Serkan Sahin and Sayaka Nagao-Sato and Jessica Severin and {de Hoon}, {Michiel J L} and Jun Kawai and Takeya Kasukawa and Timo Lassmann and Harukazu Suzuki and Hideya Kawaji and Summers, {Kim M} and Christine Wells and Hume, {David A} and Forrest, {Alistair R R} and Sandelin, {Albin Gustav} and Piero Carninci and Yoshihide Hayashizaki",
note = "Copyright {\textcopyright} 2015, American Association for the Advancement of Science.",
year = "2015",
doi = "10.1126/science.1259418",
language = "English",
volume = "347",
pages = "1010--1014",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6225",
}
RIS
TY - JOUR
T1 - Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
AU - Arner, Erik
AU - Daub, Carsten O.
AU - Vitting-Seerup, Kristoffer
AU - Andersson, Robin
AU - Lilje, Berit
AU - Drabløs, Finn
AU - Lennartsson, Andreas
AU - Rönnerblad, Michelle
AU - Hrydziuszko, Olga
AU - Vitezic, Morana
AU - Freeman, Tom C
AU - Alhendi, Ahmad M N
AU - Arner, Peter
AU - Axton, Richard
AU - Baillie, J Kenneth
AU - Beckhouse, Anthony
AU - Bodega, Beatrice
AU - Briggs, James
AU - Brombacher, Frank
AU - Davis, Margaret
AU - Detmar, Michael
AU - Ehrlund, Anna
AU - Endoh, Mitsuhiro
AU - Eslami, Afsaneh
AU - Fagiolini, Michela
AU - Fairbairn, Lynsey
AU - Faulkner, Geoffrey J
AU - Ferrai, Carmelo
AU - Fisher, Malcolm E
AU - Forrester, Lesley
AU - Goldowitz, Daniel
AU - Guler, Reto
AU - Ha, Thomas
AU - Hara, Mitsuko
AU - Herlyn, Meenhard
AU - Ikawa, Tomokatsu
AU - Kai, Chieko
AU - Kawamoto, Hiroshi
AU - Khachigian, Levon M
AU - Klinken, S Peter
AU - Kojima, Soichi
AU - Koseki, Haruhiko
AU - Klein, Sarah
AU - Mejhert, Niklas
AU - Miyaguchi, Ken
AU - Mizuno, Yosuke
AU - Morimoto, Mitsuru
AU - Morris, Kelly J
AU - Mummery, Christine
AU - Nakachi, Yutaka
AU - Ogishima, Soichi
AU - Okada-Hatakeyama, Mariko
AU - Okazaki, Yasushi
AU - Orlando, Valerio
AU - Ovchinnikov, Dmitry
AU - Passier, Robert
AU - Patrikakis, Margaret
AU - Pombo, Ana
AU - Qin, Xian-Yang
AU - Roy, Sugata
AU - Sato, Hiroki
AU - Savvi, Suzana
AU - Saxena, Alka
AU - Schwegmann, Anita
AU - Sugiyama, Daisuke
AU - Swoboda, Rolf
AU - Tanaka, Hiroshi
AU - Tomoiu, Andru
AU - Winteringham, Louise N
AU - Wolvetang, Ernst
AU - Yanagi-Mizuochi, Chiyo
AU - Yoneda, Misako
AU - Zabierowski, Susan
AU - Zhang, Peter
AU - Abugessaisa, Imad
AU - Bertin, Nicolas
AU - Diehl, Alexander D
AU - Fukuda, Shiro
AU - Furuno, Masaaki
AU - Harshbarger, Jayson
AU - Hasegawa, Akira
AU - Hori, Fumi
AU - Ishikawa-Kato, Sachi
AU - Ishizu, Yuri
AU - Itoh, Masayoshi
AU - Kawashima, Tsugumi
AU - Kojima, Miki
AU - Kondo, Naoto
AU - Lizio, Marina
AU - Meehan, Terrence F
AU - Mungall, Christopher J
AU - Murata, Mitsuyoshi
AU - Nishiyori-Sueki, Hiromi
AU - Sahin, Serkan
AU - Nagao-Sato, Sayaka
AU - Severin, Jessica
AU - de Hoon, Michiel J L
AU - Kawai, Jun
AU - Kasukawa, Takeya
AU - Lassmann, Timo
AU - Suzuki, Harukazu
AU - Kawaji, Hideya
AU - Summers, Kim M
AU - Wells, Christine
AU - Hume, David A
AU - Forrest, Alistair R R
AU - Sandelin, Albin Gustav
AU - Carninci, Piero
AU - Hayashizaki, Yoshihide
N1 - Copyright © 2015, American Association for the Advancement of Science.
PY - 2015
Y1 - 2015
N2 - Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.
AB - Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated the earliest responses. Binding sites for key lineage transcription factors were simultaneously overrepresented in enhancers and promoters active in each cellular system. Our data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.
U2 - 10.1126/science.1259418
DO - 10.1126/science.1259418
M3 - Journal article
C2 - 25678556
VL - 347
SP - 1010
EP - 1014
JO - Science
JF - Science
SN - 0036-8075
IS - 6225
ER -