Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants

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Standard

Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants. / Poulsen, Michael; Cafaro, Matías J.; Erhardt, Daniel P.; Little, Ainslie E. F.; Gerardo, Nicole M.; Tebbets, Brad; Klein, Bruce S.; Currie, Cameron R.

In: Environmental Microbiology Reports, Vol. 2, No. 4, 2010, p. 534-540.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, M, Cafaro, MJ, Erhardt, DP, Little, AEF, Gerardo, NM, Tebbets, B, Klein, BS & Currie, CR 2010, 'Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants', Environmental Microbiology Reports, vol. 2, no. 4, pp. 534-540. https://doi.org/10.1111/j.1758-2229.2009.00098.x

APA

Poulsen, M., Cafaro, M. J., Erhardt, D. P., Little, A. E. F., Gerardo, N. M., Tebbets, B., Klein, B. S., & Currie, C. R. (2010). Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants. Environmental Microbiology Reports, 2(4), 534-540. https://doi.org/10.1111/j.1758-2229.2009.00098.x

Vancouver

Poulsen M, Cafaro MJ, Erhardt DP, Little AEF, Gerardo NM, Tebbets B et al. Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants. Environmental Microbiology Reports. 2010;2(4):534-540. https://doi.org/10.1111/j.1758-2229.2009.00098.x

Author

Poulsen, Michael ; Cafaro, Matías J. ; Erhardt, Daniel P. ; Little, Ainslie E. F. ; Gerardo, Nicole M. ; Tebbets, Brad ; Klein, Bruce S. ; Currie, Cameron R. / Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants. In: Environmental Microbiology Reports. 2010 ; Vol. 2, No. 4. pp. 534-540.

Bibtex

@article{894312b95f534b8d8955cedd9caf75fc,
title = "Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants",
abstract = "P>Host-parasite associations are potentially shaped by evolutionary reciprocal selection dynamics, in which parasites evolve to overcome host defences and hosts are selected to counteract these through the evolution of new defences. This is expected to result in variation in parasite-defence interactions, and the evolution of resistant parasites causing increased virulence. Fungus-growing ants maintain antibiotic-producing Pseudonocardia (Actinobacteria) that aid in protection against specialized parasites of the ants' fungal gardens, and current evidence indicates that both symbionts have been associated with the ants for millions of years. Here we examine the extent of variation in the defensive capabilities of the ant-actinobacterial association against Escovopsis (parasite-defence interactions), and evaluate how variation impacts colonies of fungus-growing ants. We focus on five species of Acromyrmex leaf-cutting ants, crossing 12 strains of Pseudonocardia with 12 strains of Escovopsis in a Petri plate bioassay experiment, and subsequently conduct subcolony infection experiments using resistant and non-resistant parasite strains. Diversity in parasite-defence interactions, including pairings where the parasites are resistant, suggests that chemical variation in the antibiotics produced by different actinobacterial strains are responsible for the observed variation in parasite susceptibility. We evaluate the role this variation plays showing that infection of ant subcolonies with resistant parasite strains results in significantly higher parasite-induced morbidity with respect to garden biomass loss. Our findings thus further establish the role of Pseudonocardia-derived antibiotics in helping defend the ants' fungus garden from the parasite Escovopsis, and provide evidence that small molecules can play important roles as antibiotics in a natural system. ",
author = "Michael Poulsen and Cafaro, {Mat{\~A}­as J.} and Erhardt, {Daniel P.} and Little, {Ainslie E. F.} and Gerardo, {Nicole M.} and Brad Tebbets and Klein, {Bruce S.} and Currie, {Cameron R.}",
year = "2010",
doi = "10.1111/j.1758-2229.2009.00098.x",
language = "English",
volume = "2",
pages = "534--540",
journal = "Environmental Microbiology Reports",
issn = "1758-2229",
publisher = "Wiley",
number = "4",

}

RIS

TY - JOUR

T1 - Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants

AU - Poulsen, Michael

AU - Cafaro, Matías J.

AU - Erhardt, Daniel P.

AU - Little, Ainslie E. F.

AU - Gerardo, Nicole M.

AU - Tebbets, Brad

AU - Klein, Bruce S.

AU - Currie, Cameron R.

PY - 2010

Y1 - 2010

N2 - P>Host-parasite associations are potentially shaped by evolutionary reciprocal selection dynamics, in which parasites evolve to overcome host defences and hosts are selected to counteract these through the evolution of new defences. This is expected to result in variation in parasite-defence interactions, and the evolution of resistant parasites causing increased virulence. Fungus-growing ants maintain antibiotic-producing Pseudonocardia (Actinobacteria) that aid in protection against specialized parasites of the ants' fungal gardens, and current evidence indicates that both symbionts have been associated with the ants for millions of years. Here we examine the extent of variation in the defensive capabilities of the ant-actinobacterial association against Escovopsis (parasite-defence interactions), and evaluate how variation impacts colonies of fungus-growing ants. We focus on five species of Acromyrmex leaf-cutting ants, crossing 12 strains of Pseudonocardia with 12 strains of Escovopsis in a Petri plate bioassay experiment, and subsequently conduct subcolony infection experiments using resistant and non-resistant parasite strains. Diversity in parasite-defence interactions, including pairings where the parasites are resistant, suggests that chemical variation in the antibiotics produced by different actinobacterial strains are responsible for the observed variation in parasite susceptibility. We evaluate the role this variation plays showing that infection of ant subcolonies with resistant parasite strains results in significantly higher parasite-induced morbidity with respect to garden biomass loss. Our findings thus further establish the role of Pseudonocardia-derived antibiotics in helping defend the ants' fungus garden from the parasite Escovopsis, and provide evidence that small molecules can play important roles as antibiotics in a natural system.

AB - P>Host-parasite associations are potentially shaped by evolutionary reciprocal selection dynamics, in which parasites evolve to overcome host defences and hosts are selected to counteract these through the evolution of new defences. This is expected to result in variation in parasite-defence interactions, and the evolution of resistant parasites causing increased virulence. Fungus-growing ants maintain antibiotic-producing Pseudonocardia (Actinobacteria) that aid in protection against specialized parasites of the ants' fungal gardens, and current evidence indicates that both symbionts have been associated with the ants for millions of years. Here we examine the extent of variation in the defensive capabilities of the ant-actinobacterial association against Escovopsis (parasite-defence interactions), and evaluate how variation impacts colonies of fungus-growing ants. We focus on five species of Acromyrmex leaf-cutting ants, crossing 12 strains of Pseudonocardia with 12 strains of Escovopsis in a Petri plate bioassay experiment, and subsequently conduct subcolony infection experiments using resistant and non-resistant parasite strains. Diversity in parasite-defence interactions, including pairings where the parasites are resistant, suggests that chemical variation in the antibiotics produced by different actinobacterial strains are responsible for the observed variation in parasite susceptibility. We evaluate the role this variation plays showing that infection of ant subcolonies with resistant parasite strains results in significantly higher parasite-induced morbidity with respect to garden biomass loss. Our findings thus further establish the role of Pseudonocardia-derived antibiotics in helping defend the ants' fungus garden from the parasite Escovopsis, and provide evidence that small molecules can play important roles as antibiotics in a natural system.

U2 - 10.1111/j.1758-2229.2009.00098.x

DO - 10.1111/j.1758-2229.2009.00098.x

M3 - Journal article

C2 - 22896766

VL - 2

SP - 534

EP - 540

JO - Environmental Microbiology Reports

JF - Environmental Microbiology Reports

SN - 1758-2229

IS - 4

ER -

ID: 33762339