Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people
Research output: Contribution to journal › Journal article › Research › peer-review
Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 50 |
| Issue number | 6 |
| Pages (from-to) | 1201-1208 |
| Number of pages | 8 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - 2007 |
- Adult, DNA Mutational Analysis, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Variation, Genome, Glucose, Humans, Lipids, Liver, Male, Middle Aged, Muscle, Skeletal, PPAR delta, Polymorphism, Genetic
Research areas
ID: 45426246