3did: a catalog of domain-based interactions of known three-dimensional structure

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  • 3did

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The database of 3D interacting domains (3did, available online for browsing and bulk download at http://3did.irbbarcelona.org) is a catalog of protein-protein interactions for which a high-resolution 3D structure is known. 3did collects and classifies all structural templates of domain-domain interactions in the Protein Data Bank, providing molecular details for such interactions. The current version also includes a pipeline for the discovery and annotation of novel domain-motif interactions. For every interaction, 3did identifies and groups different binding modes by clustering similar interfaces into 'interaction topologies'. By maintaining a constantly updated collection of domain-based structural interaction templates, 3did is a reference source of information for the structural characterization of protein interaction networks. 3did is updated every 6 months.

Original languageEnglish
JournalNucleic Acids Research
Issue numberD1
Pages (from-to)D374-D379
Publication statusPublished - 2014
Externally publishedYes

    Research areas

  • Databases, Protein, Internet, Models, Molecular, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Protein Interaction Maps

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