Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies

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Anti-CRISPR protein applications : natural brakes for CRISPR-Cas technologies. / Marino, Nicole D.; Pinilla-Redondo, Rafael; Csörgő, Bálint; Bondy-Denomy, Joseph.

In: Nature Methods, Vol. 17, No. 5, 2020, p. 471-479.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Marino, ND, Pinilla-Redondo, R, Csörgő, B & Bondy-Denomy, J 2020, 'Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies', Nature Methods, vol. 17, no. 5, pp. 471-479. https://doi.org/10.1038/s41592-020-0771-6

APA

Marino, N. D., Pinilla-Redondo, R., Csörgő, B., & Bondy-Denomy, J. (2020). Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies. Nature Methods, 17(5), 471-479. https://doi.org/10.1038/s41592-020-0771-6

Vancouver

Marino ND, Pinilla-Redondo R, Csörgő B, Bondy-Denomy J. Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies. Nature Methods. 2020;17(5):471-479. https://doi.org/10.1038/s41592-020-0771-6

Author

Marino, Nicole D. ; Pinilla-Redondo, Rafael ; Csörgő, Bálint ; Bondy-Denomy, Joseph. / Anti-CRISPR protein applications : natural brakes for CRISPR-Cas technologies. In: Nature Methods. 2020 ; Vol. 17, No. 5. pp. 471-479.

Bibtex

@article{f1a07ac363014f2990e3f0ff6a366e18,
title = "Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies",
abstract = "Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.",
author = "Marino, {Nicole D.} and Rafael Pinilla-Redondo and B{\'a}lint Cs{\"o}rg{\H o} and Joseph Bondy-Denomy",
year = "2020",
doi = "10.1038/s41592-020-0771-6",
language = "English",
volume = "17",
pages = "471--479",
journal = "Nature Methods",
issn = "1548-7091",
publisher = "nature publishing group",
number = "5",

}

RIS

TY - JOUR

T1 - Anti-CRISPR protein applications

T2 - natural brakes for CRISPR-Cas technologies

AU - Marino, Nicole D.

AU - Pinilla-Redondo, Rafael

AU - Csörgő, Bálint

AU - Bondy-Denomy, Joseph

PY - 2020

Y1 - 2020

N2 - Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.

AB - Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.

U2 - 10.1038/s41592-020-0771-6

DO - 10.1038/s41592-020-0771-6

M3 - Review

C2 - 32203383

AN - SCOPUS:85082704813

VL - 17

SP - 471

EP - 479

JO - Nature Methods

JF - Nature Methods

SN - 1548-7091

IS - 5

ER -

ID: 239855966