Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
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Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice. / Knutsen, Helle K; Olstørn, Hege B; Paulsen, Jan Erik; Husøy, Trine; Goverud, Ingeborg L; Løberg, Else Marit; Kristiansen, Karsten; Alexander, Jan.
In: Anticancer Research, Vol. 25, No. 6B, 2011, p. 3781-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
AU - Knutsen, Helle K
AU - Olstørn, Hege B
AU - Paulsen, Jan Erik
AU - Husøy, Trine
AU - Goverud, Ingeborg L
AU - Løberg, Else Marit
AU - Kristiansen, Karsten
AU - Alexander, Jan
PY - 2011
Y1 - 2011
N2 - In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.
AB - In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.
M3 - Journal article
C2 - 16309164
VL - 25
SP - 3781
EP - 3789
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 6B
ER -
ID: 35457528