Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
Research output: Contribution to journal › Journal article › Research › peer-review
In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.
| Original language | English |
|---|---|
| Journal | Anticancer Research |
| Volume | 25 |
| Issue number | 6B |
| Pages (from-to) | 3781-9 |
| Number of pages | 9 |
| ISSN | 0250-7005 |
| Publication status | Published - 2011 |
| Externally published | Yes |
ID: 35457528