Pharmacogenomics genes show varying perceptibility to microRNA regulation

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Pharmacogenomics genes show varying perceptibility to microRNA regulation. / Rukov, Jakob Lewin; Vinther, Jeppe; Shomron, Noam.

In: Pharmacogenetics and Genomics, Vol. 21, No. 5, 2011, p. 251-62.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rukov, JL, Vinther, J & Shomron, N 2011, 'Pharmacogenomics genes show varying perceptibility to microRNA regulation', Pharmacogenetics and Genomics, vol. 21, no. 5, pp. 251-62. https://doi.org/10.1097/FPC.0b013e3283438865

APA

Rukov, J. L., Vinther, J., & Shomron, N. (2011). Pharmacogenomics genes show varying perceptibility to microRNA regulation. Pharmacogenetics and Genomics, 21(5), 251-62. https://doi.org/10.1097/FPC.0b013e3283438865

Vancouver

Rukov JL, Vinther J, Shomron N. Pharmacogenomics genes show varying perceptibility to microRNA regulation. Pharmacogenetics and Genomics. 2011;21(5):251-62. https://doi.org/10.1097/FPC.0b013e3283438865

Author

Rukov, Jakob Lewin ; Vinther, Jeppe ; Shomron, Noam. / Pharmacogenomics genes show varying perceptibility to microRNA regulation. In: Pharmacogenetics and Genomics. 2011 ; Vol. 21, No. 5. pp. 251-62.

Bibtex

@article{8d249c94da9740cca6eebc50820242cf,
title = "Pharmacogenomics genes show varying perceptibility to microRNA regulation",
abstract = "The aim of pharmacogenomics is to identify individual differences in genome and transcriptome composition and their effect on drug efficacy. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate expression of the majority of animal genes, including many genes involved in drug efficacy. Consequently, differences in the miRNA expression among individuals could be an important factor contributing to differential drug response. Pharmacogenomics genes can be divided into drug target genes termed as pharmacodynamics genes (PD) and genes involved in drug transport and metabolism termed as pharmacokinetics genes (PK). To clarify the regulatory potential of miRNAs in pharmacogenomics, we have examined the potential regulation by miRNAs of PK and PD genes.",
keywords = "Animals, Cell Line, Gene Expression Regulation, Gene Knockdown Techniques, Humans, MicroRNAs, Pharmacogenetics, Pharmacokinetics, Pharmacological Processes, Ribonuclease III",
author = "Rukov, {Jakob Lewin} and Jeppe Vinther and Noam Shomron",
year = "2011",
doi = "10.1097/FPC.0b013e3283438865",
language = "English",
volume = "21",
pages = "251--62",
journal = "Pharmacogenetics",
issn = "1744-6872",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Pharmacogenomics genes show varying perceptibility to microRNA regulation

AU - Rukov, Jakob Lewin

AU - Vinther, Jeppe

AU - Shomron, Noam

PY - 2011

Y1 - 2011

N2 - The aim of pharmacogenomics is to identify individual differences in genome and transcriptome composition and their effect on drug efficacy. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate expression of the majority of animal genes, including many genes involved in drug efficacy. Consequently, differences in the miRNA expression among individuals could be an important factor contributing to differential drug response. Pharmacogenomics genes can be divided into drug target genes termed as pharmacodynamics genes (PD) and genes involved in drug transport and metabolism termed as pharmacokinetics genes (PK). To clarify the regulatory potential of miRNAs in pharmacogenomics, we have examined the potential regulation by miRNAs of PK and PD genes.

AB - The aim of pharmacogenomics is to identify individual differences in genome and transcriptome composition and their effect on drug efficacy. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate expression of the majority of animal genes, including many genes involved in drug efficacy. Consequently, differences in the miRNA expression among individuals could be an important factor contributing to differential drug response. Pharmacogenomics genes can be divided into drug target genes termed as pharmacodynamics genes (PD) and genes involved in drug transport and metabolism termed as pharmacokinetics genes (PK). To clarify the regulatory potential of miRNAs in pharmacogenomics, we have examined the potential regulation by miRNAs of PK and PD genes.

KW - Animals

KW - Cell Line

KW - Gene Expression Regulation

KW - Gene Knockdown Techniques

KW - Humans

KW - MicroRNAs

KW - Pharmacogenetics

KW - Pharmacokinetics

KW - Pharmacological Processes

KW - Ribonuclease III

U2 - 10.1097/FPC.0b013e3283438865

DO - 10.1097/FPC.0b013e3283438865

M3 - Journal article

C2 - 21499217

VL - 21

SP - 251

EP - 262

JO - Pharmacogenetics

JF - Pharmacogenetics

SN - 1744-6872

IS - 5

ER -

ID: 33959468