Pharmacogenomics genes show varying perceptibility to microRNA regulation
Research output: Contribution to journal › Journal article › Research › peer-review
The aim of pharmacogenomics is to identify individual differences in genome and transcriptome composition and their effect on drug efficacy. MicroRNAs (miRNAs) are short noncoding RNAs that negatively regulate expression of the majority of animal genes, including many genes involved in drug efficacy. Consequently, differences in the miRNA expression among individuals could be an important factor contributing to differential drug response. Pharmacogenomics genes can be divided into drug target genes termed as pharmacodynamics genes (PD) and genes involved in drug transport and metabolism termed as pharmacokinetics genes (PK). To clarify the regulatory potential of miRNAs in pharmacogenomics, we have examined the potential regulation by miRNAs of PK and PD genes.
Original language | English |
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Journal | Pharmacogenetics and Genomics |
Volume | 21 |
Issue number | 5 |
Pages (from-to) | 251-62 |
Number of pages | 12 |
ISSN | 1744-6872 |
DOIs | |
Publication status | Published - 2011 |
- Animals, Cell Line, Gene Expression Regulation, Gene Knockdown Techniques, Humans, MicroRNAs, Pharmacogenetics, Pharmacokinetics, Pharmacological Processes, Ribonuclease III
Research areas
ID: 33959468