Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma. / Zhang, Rongxin; Feng, Yu; Ma, Wenjuan; Guo, Yanying; Luo, Mei; Li, Young; Zang, Yupeng; Dong, Xuan; Lu, Shixun; Guo, Qiang; Xu, Qumiao; Chen, Huanyi; Li, Yijian; Liu, Longqi; Chen, Ao; Chen, Gong; Xu, Xun.

In: Fundamental Research, Vol. 3, No. 4, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, R, Feng, Y, Ma, W, Guo, Y, Luo, M, Li, Y, Zang, Y, Dong, X, Lu, S, Guo, Q, Xu, Q, Chen, H, Li, Y, Liu, L, Chen, A, Chen, G & Xu, X 2023, 'Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma', Fundamental Research, vol. 3, no. 4. https://doi.org/10.1016/j.fmre.2022.01.036

APA

Zhang, R., Feng, Y., Ma, W., Guo, Y., Luo, M., Li, Y., Zang, Y., Dong, X., Lu, S., Guo, Q., Xu, Q., Chen, H., Li, Y., Liu, L., Chen, A., Chen, G., & Xu, X. (2023). Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma. Fundamental Research, 3(4). https://doi.org/10.1016/j.fmre.2022.01.036

Vancouver

Zhang R, Feng Y, Ma W, Guo Y, Luo M, Li Y et al. Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma. Fundamental Research. 2023;3(4). https://doi.org/10.1016/j.fmre.2022.01.036

Author

Zhang, Rongxin ; Feng, Yu ; Ma, Wenjuan ; Guo, Yanying ; Luo, Mei ; Li, Young ; Zang, Yupeng ; Dong, Xuan ; Lu, Shixun ; Guo, Qiang ; Xu, Qumiao ; Chen, Huanyi ; Li, Yijian ; Liu, Longqi ; Chen, Ao ; Chen, Gong ; Xu, Xun. / Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma. In: Fundamental Research. 2023 ; Vol. 3, No. 4.

Bibtex

@article{8e422386ed264354bf5f58045f5a8311,
title = "Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma",
abstract = "The preexistence of immune cells in the tumor microenvironment substantiates the efficacy of immunotherapy in cancer patients. Although the complex intratumoral immune heterogeneity has been extensively studied in single cell resolution, hi-res spatial investigations are limited. In this study, we performed a spatial transcriptome analysis of 4 colorectal adenocarcinoma specimens and 2 paired distant normal specimens to identify the molecular pattern involved in a discontinuous inflammatory response in pathologically annotated cancer regions. Based on the location of spatially varied gene expression, we unmasked the spatially-varied immune ecosystem and identified the locoregional “warmed-up” immune response in predefined “cold” tumor with substantial infiltration of immune components. This “warmed-up” immune profile was found to be associated with the in-situ copy number variance and the tissue remodeling process. Further, “warmed-up” signature genes indicated improved overall survival in CRC patients obtained from TCGA database.",
keywords = "Colorectal adenocarcinoma, Inflammation, Mismatch repair, Spatial transcriptomics, Tumor microenvironment",
author = "Rongxin Zhang and Yu Feng and Wenjuan Ma and Yanying Guo and Mei Luo and Young Li and Yupeng Zang and Xuan Dong and Shixun Lu and Qiang Guo and Qumiao Xu and Huanyi Chen and Yijian Li and Longqi Liu and Ao Chen and Gong Chen and Xun Xu",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2023",
doi = "10.1016/j.fmre.2022.01.036",
language = "English",
volume = "3",
journal = "Fundamental Research",
issn = "2667-3258",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinoma

AU - Zhang, Rongxin

AU - Feng, Yu

AU - Ma, Wenjuan

AU - Guo, Yanying

AU - Luo, Mei

AU - Li, Young

AU - Zang, Yupeng

AU - Dong, Xuan

AU - Lu, Shixun

AU - Guo, Qiang

AU - Xu, Qumiao

AU - Chen, Huanyi

AU - Li, Yijian

AU - Liu, Longqi

AU - Chen, Ao

AU - Chen, Gong

AU - Xu, Xun

N1 - Publisher Copyright: © 2022

PY - 2023

Y1 - 2023

N2 - The preexistence of immune cells in the tumor microenvironment substantiates the efficacy of immunotherapy in cancer patients. Although the complex intratumoral immune heterogeneity has been extensively studied in single cell resolution, hi-res spatial investigations are limited. In this study, we performed a spatial transcriptome analysis of 4 colorectal adenocarcinoma specimens and 2 paired distant normal specimens to identify the molecular pattern involved in a discontinuous inflammatory response in pathologically annotated cancer regions. Based on the location of spatially varied gene expression, we unmasked the spatially-varied immune ecosystem and identified the locoregional “warmed-up” immune response in predefined “cold” tumor with substantial infiltration of immune components. This “warmed-up” immune profile was found to be associated with the in-situ copy number variance and the tissue remodeling process. Further, “warmed-up” signature genes indicated improved overall survival in CRC patients obtained from TCGA database.

AB - The preexistence of immune cells in the tumor microenvironment substantiates the efficacy of immunotherapy in cancer patients. Although the complex intratumoral immune heterogeneity has been extensively studied in single cell resolution, hi-res spatial investigations are limited. In this study, we performed a spatial transcriptome analysis of 4 colorectal adenocarcinoma specimens and 2 paired distant normal specimens to identify the molecular pattern involved in a discontinuous inflammatory response in pathologically annotated cancer regions. Based on the location of spatially varied gene expression, we unmasked the spatially-varied immune ecosystem and identified the locoregional “warmed-up” immune response in predefined “cold” tumor with substantial infiltration of immune components. This “warmed-up” immune profile was found to be associated with the in-situ copy number variance and the tissue remodeling process. Further, “warmed-up” signature genes indicated improved overall survival in CRC patients obtained from TCGA database.

KW - Colorectal adenocarcinoma

KW - Inflammation

KW - Mismatch repair

KW - Spatial transcriptomics

KW - Tumor microenvironment

U2 - 10.1016/j.fmre.2022.01.036

DO - 10.1016/j.fmre.2022.01.036

M3 - Journal article

AN - SCOPUS:85128285510

VL - 3

JO - Fundamental Research

JF - Fundamental Research

SN - 2667-3258

IS - 4

ER -

ID: 310558072