Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies
Research output: Contribution to journal › Journal article › Research › peer-review
In the present study, we aimed to validate the type 2 diabetes susceptibility alleles identified in six recent genome-wide association studies in the HHEX/KIF11/IDE (rs1111875), CDKN2A/B (rs10811661), and IGF2BP2 (rs4402960) loci, as well as the intergenic rs9300039 variant. Furthermore, we aimed to characterize quantitative metabolic risk phenotypes of the four variants.
| Original language | English |
|---|---|
| Journal | Diabetes |
| Volume | 56 |
| Issue number | 12 |
| Pages (from-to) | 3105-3111 |
| Number of pages | 7 |
| ISSN | 0012-1797 |
| DOIs | |
| Publication status | Published - 2007 |
- Adult, Cohort Studies, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p16, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Glucose Intolerance, Homeodomain Proteins, Humans, Insulin, Insulin-Like Growth Factor Binding Protein 2, Introns, Middle Aged, Reference Values, Reproducibility of Results, Transcription Factors
Research areas
ID: 38335610