Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i.

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Standard

Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. / Wulff, Tune; Hougaard, Charlotte; Klaerke, Dan A; Hoffmann, Else K.

I: BBA General Subjects, Bind 1660, Nr. 1-2, 2004, s. 75-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wulff, T, Hougaard, C, Klaerke, DA & Hoffmann, EK 2004, 'Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i.', BBA General Subjects, bind 1660, nr. 1-2, s. 75-9. https://doi.org/10.1016/j.bbamem.2003.11.001

APA

Wulff, T., Hougaard, C., Klaerke, D. A., & Hoffmann, E. K. (2004). Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. BBA General Subjects, 1660(1-2), 75-9. https://doi.org/10.1016/j.bbamem.2003.11.001

Vancouver

Wulff T, Hougaard C, Klaerke DA, Hoffmann EK. Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. BBA General Subjects. 2004;1660(1-2):75-9. https://doi.org/10.1016/j.bbamem.2003.11.001

Author

Wulff, Tune ; Hougaard, Charlotte ; Klaerke, Dan A ; Hoffmann, Else K. / Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i. I: BBA General Subjects. 2004 ; Bind 1660, Nr. 1-2. s. 75-9.

Bibtex

@article{5b171780a0f311dd86a6000ea68e967b,
title = "Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i.",
abstract = "Addition of LTD4 (10 nM) to Xenopus laevis oocytes expressing the mCysLT1 receptor together with hBK or hIK channels resulted in the activation of both channels secondary to an LTD4-induced increase in [Ca2+]i. In addition, the hIK channel is activated by low concentrations of LTD4 (<0.1 nM), which did not result in any increase in [Ca2+]i. Even though activation of hIK by low concentrations of LTD4 was independent of an increase in [Ca2+]i, a certain {"}permissive{"} level of [Ca2+]i was required for its activation, since buffering of intracellular Ca2+ by EGTA completely abolished the response to LTD4. Neither hTBAK1 nor hTASK2 was activated following stimulations with LTD4 (0.1 and 100 nM).",
author = "Tune Wulff and Charlotte Hougaard and Klaerke, {Dan A} and Hoffmann, {Else K}",
note = "Keywords: Animals; Calcium; Cations, Divalent; Cell Line; Cytokines; Egtazic Acid; Humans; Hydrogen-Ion Concentration; Large-Conductance Calcium-Activated Potassium Channels; Leukotriene D4; Membrane Proteins; Oocytes; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Tandem Pore Domain; RNA, Complementary; Receptors, Leukotriene; Transfection; Xenopus laevis",
year = "2004",
doi = "10.1016/j.bbamem.2003.11.001",
language = "English",
volume = "1660",
pages = "75--9",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Co-expression of mCysLT1 receptors and IK channels in Xenopus laevis oocytes elicits LTD4-stimulated IK current, independent of an increase in [Ca2+]i.

AU - Wulff, Tune

AU - Hougaard, Charlotte

AU - Klaerke, Dan A

AU - Hoffmann, Else K

N1 - Keywords: Animals; Calcium; Cations, Divalent; Cell Line; Cytokines; Egtazic Acid; Humans; Hydrogen-Ion Concentration; Large-Conductance Calcium-Activated Potassium Channels; Leukotriene D4; Membrane Proteins; Oocytes; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Tandem Pore Domain; RNA, Complementary; Receptors, Leukotriene; Transfection; Xenopus laevis

PY - 2004

Y1 - 2004

N2 - Addition of LTD4 (10 nM) to Xenopus laevis oocytes expressing the mCysLT1 receptor together with hBK or hIK channels resulted in the activation of both channels secondary to an LTD4-induced increase in [Ca2+]i. In addition, the hIK channel is activated by low concentrations of LTD4 (<0.1 nM), which did not result in any increase in [Ca2+]i. Even though activation of hIK by low concentrations of LTD4 was independent of an increase in [Ca2+]i, a certain "permissive" level of [Ca2+]i was required for its activation, since buffering of intracellular Ca2+ by EGTA completely abolished the response to LTD4. Neither hTBAK1 nor hTASK2 was activated following stimulations with LTD4 (0.1 and 100 nM).

AB - Addition of LTD4 (10 nM) to Xenopus laevis oocytes expressing the mCysLT1 receptor together with hBK or hIK channels resulted in the activation of both channels secondary to an LTD4-induced increase in [Ca2+]i. In addition, the hIK channel is activated by low concentrations of LTD4 (<0.1 nM), which did not result in any increase in [Ca2+]i. Even though activation of hIK by low concentrations of LTD4 was independent of an increase in [Ca2+]i, a certain "permissive" level of [Ca2+]i was required for its activation, since buffering of intracellular Ca2+ by EGTA completely abolished the response to LTD4. Neither hTBAK1 nor hTASK2 was activated following stimulations with LTD4 (0.1 and 100 nM).

U2 - 10.1016/j.bbamem.2003.11.001

DO - 10.1016/j.bbamem.2003.11.001

M3 - Journal article

C2 - 14757222

VL - 1660

SP - 75

EP - 79

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 1-2

ER -

ID: 6768716