Cutting edge: Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5

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Standard

Cutting edge : Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5. / Jinquan, Tan; Quan, Sha; Jacobi, Henrik H.; Reimert, Claus M.; Millner, Anders; Hansen, Jens B.; Thygesen, Charlotte; Ryder, Lars P.; Madsen, Hans O.; Malling, Hans Jørgen; Poulsen, Lars K.

I: Journal of Immunology, Bind 163, Nr. 1, 01.07.1999, s. 21-24.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jinquan, T, Quan, S, Jacobi, HH, Reimert, CM, Millner, A, Hansen, JB, Thygesen, C, Ryder, LP, Madsen, HO, Malling, HJ & Poulsen, LK 1999, 'Cutting edge: Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5', Journal of Immunology, bind 163, nr. 1, s. 21-24.

APA

Jinquan, T., Quan, S., Jacobi, H. H., Reimert, C. M., Millner, A., Hansen, J. B., Thygesen, C., Ryder, L. P., Madsen, H. O., Malling, H. J., & Poulsen, L. K. (1999). Cutting edge: Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5. Journal of Immunology, 163(1), 21-24.

Vancouver

Jinquan T, Quan S, Jacobi HH, Reimert CM, Millner A, Hansen JB o.a. Cutting edge: Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5. Journal of Immunology. 1999 jul. 1;163(1):21-24.

Author

Jinquan, Tan ; Quan, Sha ; Jacobi, Henrik H. ; Reimert, Claus M. ; Millner, Anders ; Hansen, Jens B. ; Thygesen, Charlotte ; Ryder, Lars P. ; Madsen, Hans O. ; Malling, Hans Jørgen ; Poulsen, Lars K. / Cutting edge : Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5. I: Journal of Immunology. 1999 ; Bind 163, Nr. 1. s. 21-24.

Bibtex

@article{4f46fe7d8518499b81a72d00a40aaf84,
title = "Cutting edge: Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5",
abstract = "We report that NF-AT1 and NF-AT4 are expressed cytoplasmically in resting eosinophils, whereas NF-AT2 and NF-AT3 have not been seen. Likewise, NF-AT1 mRNA and NF-AT4 mRNA have been detected in resting eosinophils, and their levels can be significantly up-regulated by the Th2-associated cytokines IL-4 and IL-5. There is no detectable NF-AT protein expression in the nuclei of resting eosinophils. However NFATs appear in the nuclei of IL- 4-, IL-5-, or ionomycin-stimulated eosinophils. Only NF-AT1 and NF-AT4, but not NF-AT2 and NF-AT3, have translocated into the nuclei in IL-4- or IL5- stimulated eosinophils. These findings delineate a novel pathway in the cytokine network in which Th2 lymphocytes 'control' eosinophils via the release of IL-4 and IL-5, and activation of NF-AT in eosinophils. The findings also suggest that a later feedback 'talking' may exist between eosinophils and Th2 lymphocytes.",
author = "Tan Jinquan and Sha Quan and Jacobi, {Henrik H.} and Reimert, {Claus M.} and Anders Millner and Hansen, {Jens B.} and Charlotte Thygesen and Ryder, {Lars P.} and Madsen, {Hans O.} and Malling, {Hans J{\o}rgen} and Poulsen, {Lars K.}",
year = "1999",
month = jul,
day = "1",
language = "English",
volume = "163",
pages = "21--24",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "1",

}

RIS

TY - JOUR

T1 - Cutting edge

T2 - Expression of the NF of activated T cells in eosinophils: Regulation by IL-4 and IL-5

AU - Jinquan, Tan

AU - Quan, Sha

AU - Jacobi, Henrik H.

AU - Reimert, Claus M.

AU - Millner, Anders

AU - Hansen, Jens B.

AU - Thygesen, Charlotte

AU - Ryder, Lars P.

AU - Madsen, Hans O.

AU - Malling, Hans Jørgen

AU - Poulsen, Lars K.

PY - 1999/7/1

Y1 - 1999/7/1

N2 - We report that NF-AT1 and NF-AT4 are expressed cytoplasmically in resting eosinophils, whereas NF-AT2 and NF-AT3 have not been seen. Likewise, NF-AT1 mRNA and NF-AT4 mRNA have been detected in resting eosinophils, and their levels can be significantly up-regulated by the Th2-associated cytokines IL-4 and IL-5. There is no detectable NF-AT protein expression in the nuclei of resting eosinophils. However NFATs appear in the nuclei of IL- 4-, IL-5-, or ionomycin-stimulated eosinophils. Only NF-AT1 and NF-AT4, but not NF-AT2 and NF-AT3, have translocated into the nuclei in IL-4- or IL5- stimulated eosinophils. These findings delineate a novel pathway in the cytokine network in which Th2 lymphocytes 'control' eosinophils via the release of IL-4 and IL-5, and activation of NF-AT in eosinophils. The findings also suggest that a later feedback 'talking' may exist between eosinophils and Th2 lymphocytes.

AB - We report that NF-AT1 and NF-AT4 are expressed cytoplasmically in resting eosinophils, whereas NF-AT2 and NF-AT3 have not been seen. Likewise, NF-AT1 mRNA and NF-AT4 mRNA have been detected in resting eosinophils, and their levels can be significantly up-regulated by the Th2-associated cytokines IL-4 and IL-5. There is no detectable NF-AT protein expression in the nuclei of resting eosinophils. However NFATs appear in the nuclei of IL- 4-, IL-5-, or ionomycin-stimulated eosinophils. Only NF-AT1 and NF-AT4, but not NF-AT2 and NF-AT3, have translocated into the nuclei in IL-4- or IL5- stimulated eosinophils. These findings delineate a novel pathway in the cytokine network in which Th2 lymphocytes 'control' eosinophils via the release of IL-4 and IL-5, and activation of NF-AT in eosinophils. The findings also suggest that a later feedback 'talking' may exist between eosinophils and Th2 lymphocytes.

UR - http://www.scopus.com/inward/record.url?scp=0033168174&partnerID=8YFLogxK

M3 - Journal article

C2 - 10384094

AN - SCOPUS:0033168174

VL - 163

SP - 21

EP - 24

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 1

ER -

ID: 328565366