TY - JOUR

T1 - Fluorodeoxyglucose uptake in dysfunctional myocardium subtended by an occluded coronary artery

T2 - Relation to dobutamine contractile reserve and Sestamibi uptake

AU - Kofoed, Klaus F.

AU - Carstensen, Steen

AU - Hesse, Birger

AU - Hove, Jens D.

AU - Holm, Søren

AU - Jensen, Mikael

AU - Haunsø, Stig

AU - Kelbæk, Henning

N1 - Funding Information: This study was supported by the Danish Heart Foundation, The Birthe and John Meyer foundation and the Foundation of 1921 and the Foundation of 1870. The assistance of Drs. P. Larsen, and J. L. Madsen, the Cyclotron and PET Unit, Department of Nuclear Medicine Rigshopsitalet is highly appreciated. L. Jensen, A. Gerlach and K. Petersen are thanked for technical assistance and Dr K. Sun, UCLA School of Medicine for fruitful discussions.

PY - 1998

Y1 - 1998

N2 - Background. Myocardial segments with impaired function may have the potential for functional recovery. Augmented exogenous glucose uptake in relation to blood flow estimated by [2-18F]2-fluorodeoxyglucose (FDG) and positron emission tomography (PET) frequently indicates functional reversibility. The spectrum of FDG uptake levels in relation to Sestamibi uptake and dobutamine contraction reserve in areas with impaired function subtended by an occluded coronary artery has never been reported. Methods and results. Seventeen patients with stable angina pectoris and dysfunctional myocardium subtended by an occluded coronary artery were studied with FDG-PET, low-dose dobutamine echocardiography and Sestamibi - Single Photon Emission Computerized Tomography. In a 16 segment model dysfunctional myocardial segments showed a normally distributed FDG uptake ranging from 34% to 150% when normalized to peak segmental Sestamibi uptake. Low FDG uptake was associated with both lack of dobutamine induced contractile reserve and low Sestamibi uptake (in 73% of the segments) whereas high FDG uptake displayed both contractile reserve and Sestamibi uptake (57%). Segments with intermediate FDG uptake had either contractile reserve or a preserved Sestamibi uptake (62%). Conclusion. Dysfunctional myocardium subtended by an occluded coronary artery represents a continuum of metabolic states with a high degree of heterogeneity with regard to contractile reserve and Sestamibi uptake.

AB - Background. Myocardial segments with impaired function may have the potential for functional recovery. Augmented exogenous glucose uptake in relation to blood flow estimated by [2-18F]2-fluorodeoxyglucose (FDG) and positron emission tomography (PET) frequently indicates functional reversibility. The spectrum of FDG uptake levels in relation to Sestamibi uptake and dobutamine contraction reserve in areas with impaired function subtended by an occluded coronary artery has never been reported. Methods and results. Seventeen patients with stable angina pectoris and dysfunctional myocardium subtended by an occluded coronary artery were studied with FDG-PET, low-dose dobutamine echocardiography and Sestamibi - Single Photon Emission Computerized Tomography. In a 16 segment model dysfunctional myocardial segments showed a normally distributed FDG uptake ranging from 34% to 150% when normalized to peak segmental Sestamibi uptake. Low FDG uptake was associated with both lack of dobutamine induced contractile reserve and low Sestamibi uptake (in 73% of the segments) whereas high FDG uptake displayed both contractile reserve and Sestamibi uptake (57%). Segments with intermediate FDG uptake had either contractile reserve or a preserved Sestamibi uptake (62%). Conclusion. Dysfunctional myocardium subtended by an occluded coronary artery represents a continuum of metabolic states with a high degree of heterogeneity with regard to contractile reserve and Sestamibi uptake.

KW - Dobutamine echocardiography

KW - Myocardial viability

KW - PET

KW - SPECT

UR - http://www.scopus.com/inward/record.url?scp=0031980923&partnerID=8YFLogxK

U2 - 10.1023/A:1005913113840

DO - 10.1023/A:1005913113840

M3 - Journal article

C2 - 9617639

AN - SCOPUS:0031980923

VL - 14

SP - 97

EP - 104

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 2

ER -