Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies
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Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies. / Avalos, Arián; Fang, Miaoquan; Pan, Hailin; Lluch, Aixa Ramirez; Lipka, Alexander E.; Zhao, Sihai Dave; Giray, Tugrul; Robinson, Gene E.; Zhang, Guojie; Hudson, Matthew E.
I: Proceedings of the National Academy of Sciences of the United States of America, Bind 117, Nr. 29, 2020, s. 17135-17141.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies
AU - Avalos, Arián
AU - Fang, Miaoquan
AU - Pan, Hailin
AU - Lluch, Aixa Ramirez
AU - Lipka, Alexander E.
AU - Zhao, Sihai Dave
AU - Giray, Tugrul
AU - Robinson, Gene E.
AU - Zhang, Guojie
AU - Hudson, Matthew E.
PY - 2020
Y1 - 2020
N2 - For social animals, the genotypes of group members affect the social environment, and thus individual behavior, often indirectly. We used genome-wide association studies (GWAS) to determine the influence of individual vs. group genotypes on aggression in honey bees. Aggression in honey bees arises from the coordinated actions of colony members, primarily nonreproductive "soldier" bees, and thus, experiences evolutionary selection at the colony level. Here, we show that individual behavior is influenced by colony environment, which in turn, is shaped by allele frequency within colonies. Using a population with a range of aggression, we sequenced individual whole genomes and looked for genotype-behavior associations within colonies in a common environment. There were no significant correlations between individual aggression and specific alleles. By contrast, we found strong correlations between colony aggression and the frequencies of specific alleles within colonies, despite a small number of colonies. Associations at the colony level were highly significant and were very similar among both soldiers and foragers, but they covaried with one another. One strongly significant association peak, containing an ortholog of the Drosophila sensory gene dpr4 on linkage group (chromosome) 7, showed strong signals of both selection and admixture during the evolution of gentleness in a honey bee population. We thus found links between colony genetics and group behavior and also, molec-ular evidence for group-level selection, acting at the colony level. We conclude that group genetics dominates individual genetics in deter-mining the fatal decision of honey bees to sting.
AB - For social animals, the genotypes of group members affect the social environment, and thus individual behavior, often indirectly. We used genome-wide association studies (GWAS) to determine the influence of individual vs. group genotypes on aggression in honey bees. Aggression in honey bees arises from the coordinated actions of colony members, primarily nonreproductive "soldier" bees, and thus, experiences evolutionary selection at the colony level. Here, we show that individual behavior is influenced by colony environment, which in turn, is shaped by allele frequency within colonies. Using a population with a range of aggression, we sequenced individual whole genomes and looked for genotype-behavior associations within colonies in a common environment. There were no significant correlations between individual aggression and specific alleles. By contrast, we found strong correlations between colony aggression and the frequencies of specific alleles within colonies, despite a small number of colonies. Associations at the colony level were highly significant and were very similar among both soldiers and foragers, but they covaried with one another. One strongly significant association peak, containing an ortholog of the Drosophila sensory gene dpr4 on linkage group (chromosome) 7, showed strong signals of both selection and admixture during the evolution of gentleness in a honey bee population. We thus found links between colony genetics and group behavior and also, molec-ular evidence for group-level selection, acting at the colony level. We conclude that group genetics dominates individual genetics in deter-mining the fatal decision of honey bees to sting.
KW - behavioral genetics
KW - GWAS
KW - aggression
KW - DEFENSIVE BEHAVIOR
KW - GENETIC ARCHITECTURE
KW - FAMILY POOLS
KW - TRAITS
KW - ASSOCIATION
KW - PREDICTION
KW - INFERENCE
KW - LOCI
U2 - 10.1073/pnas.1922927117
DO - 10.1073/pnas.1922927117
M3 - Journal article
C2 - 32631983
VL - 117
SP - 17135
EP - 17141
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 29
ER -
ID: 246822545