Sex differences in the oral microbiome, host traits, and their causal relationships
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 3,92 MB, PDF-dokument
The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (psex-difference < 5 × 10−8). Furthermore, we performed sex-stratified Mendelian randomization (MR) analyses and identified abundant causalities between the oral microbiome and serum metabolites. Notably, sex-specific microbes-hormonal interactions explained the mostly observed sex hormones differences such as the significant causalities enrichments for aldosterone in females and androstenedione in males. These findings illustrate the necessity of sex stratification and deepen our understanding of the interplay between the oral microbiome and serum metabolites.
Originalsprog | Engelsk |
---|---|
Artikelnummer | 105839 |
Tidsskrift | iScience |
Vol/bind | 26 |
Udgave nummer | 1 |
Antal sider | 23 |
ISSN | 2589-0042 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We sincerely thank the support provided by the China National Gene Bank. We thank all the volunteers for their time and self-collecting the oral samples using our kit. We thank for the support from the National Natural Science Foundation of China (No. 32200548 ).
Publisher Copyright:
© 2022 The Author(s)
ID: 334257592