Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. / Hargreaves, Adam D.; Zhou, Long; Christensen, Josef; Marlétaz, Ferdinand; Liu, Shiping; Li, Fang; Jansen, Peter Gildsig; Spiga, Enrico; Hansen, Matilde Thye; Pedersen, Signe Vendelbo Horn; Biswas, Shameek; Serikawa, Kyle; Fox, Brian A.; Taylor, William R.; Mulley, John Frederick; Zhang, Guojie; Heller, R. Scott; Holland, Peter W. H.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 29, 18.07.2017, p. 7677-7682.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hargreaves, AD, Zhou, L, Christensen, J, Marlétaz, F, Liu, S, Li, F, Jansen, PG, Spiga, E, Hansen, MT, Pedersen, SVH, Biswas, S, Serikawa, K, Fox, BA, Taylor, WR, Mulley, JF, Zhang, G, Heller, RS & Holland, PWH 2017, 'Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 29, pp. 7677-7682. https://doi.org/10.1073/pnas.1702930114

APA

Hargreaves, A. D., Zhou, L., Christensen, J., Marlétaz, F., Liu, S., Li, F., Jansen, P. G., Spiga, E., Hansen, M. T., Pedersen, S. V. H., Biswas, S., Serikawa, K., Fox, B. A., Taylor, W. R., Mulley, J. F., Zhang, G., Heller, R. S., & Holland, P. W. H. (2017). Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. Proceedings of the National Academy of Sciences of the United States of America, 114(29), 7677-7682. https://doi.org/10.1073/pnas.1702930114

Vancouver

Hargreaves AD, Zhou L, Christensen J, Marlétaz F, Liu S, Li F et al. Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 2017 Jul 18;114(29):7677-7682. https://doi.org/10.1073/pnas.1702930114

Author

Hargreaves, Adam D. ; Zhou, Long ; Christensen, Josef ; Marlétaz, Ferdinand ; Liu, Shiping ; Li, Fang ; Jansen, Peter Gildsig ; Spiga, Enrico ; Hansen, Matilde Thye ; Pedersen, Signe Vendelbo Horn ; Biswas, Shameek ; Serikawa, Kyle ; Fox, Brian A. ; Taylor, William R. ; Mulley, John Frederick ; Zhang, Guojie ; Heller, R. Scott ; Holland, Peter W. H. / Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. In: Proceedings of the National Academy of Sciences of the United States of America. 2017 ; Vol. 114, No. 29. pp. 7677-7682.

Bibtex

@article{d7dbe76bad9945e5b2330a905ab723ea,
title = "Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster",
abstract = "The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHox cluster which includes the insulin-regulating homeobox gene Pdx1. The sequence of sand rat Pdx1 has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution.",
keywords = "Desert rodent, Gene conversion, Homeobox, Pdx1, Type 2 diabetes",
author = "Hargreaves, {Adam D.} and Long Zhou and Josef Christensen and Ferdinand Marl{\'e}taz and Shiping Liu and Fang Li and Jansen, {Peter Gildsig} and Enrico Spiga and Hansen, {Matilde Thye} and Pedersen, {Signe Vendelbo Horn} and Shameek Biswas and Kyle Serikawa and Fox, {Brian A.} and Taylor, {William R.} and Mulley, {John Frederick} and Guojie Zhang and Heller, {R. Scott} and Holland, {Peter W. H.}",
year = "2017",
month = jul,
day = "18",
doi = "10.1073/pnas.1702930114",
language = "English",
volume = "114",
pages = "7677--7682",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "29",

}

RIS

TY - JOUR

T1 - Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster

AU - Hargreaves, Adam D.

AU - Zhou, Long

AU - Christensen, Josef

AU - Marlétaz, Ferdinand

AU - Liu, Shiping

AU - Li, Fang

AU - Jansen, Peter Gildsig

AU - Spiga, Enrico

AU - Hansen, Matilde Thye

AU - Pedersen, Signe Vendelbo Horn

AU - Biswas, Shameek

AU - Serikawa, Kyle

AU - Fox, Brian A.

AU - Taylor, William R.

AU - Mulley, John Frederick

AU - Zhang, Guojie

AU - Heller, R. Scott

AU - Holland, Peter W. H.

PY - 2017/7/18

Y1 - 2017/7/18

N2 - The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHox cluster which includes the insulin-regulating homeobox gene Pdx1. The sequence of sand rat Pdx1 has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution.

AB - The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHox cluster which includes the insulin-regulating homeobox gene Pdx1. The sequence of sand rat Pdx1 has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution.

KW - Desert rodent

KW - Gene conversion

KW - Homeobox

KW - Pdx1

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85024394310&partnerID=8YFLogxK

U2 - 10.1073/pnas.1702930114

DO - 10.1073/pnas.1702930114

M3 - Journal article

C2 - 28674003

AN - SCOPUS:85024394310

VL - 114

SP - 7677

EP - 7682

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 29

ER -

ID: 181388569