Circular and Circulating DNA in Inflammatory Bowel Disease: From Pathogenesis to Potential Molecular Therapies
Research output: Contribution to journal › Review › Research › peer-review
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Circular and Circulating DNA in Inflammatory Bowel Disease : From Pathogenesis to Potential Molecular Therapies. / Di Vincenzo, Federica; Yadid, Ylenia; Petito, Valentina; Emoli, Valeria; Masi, Letizia; Gerovska, Daniela; Araúzo-Bravo, Marcos Jesus; Gasbarrini, Antonio; Regenberg, Birgitte; Scaldaferri, Franco.
In: Cells, Vol. 12, No. 15, 1953, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Circular and Circulating DNA in Inflammatory Bowel Disease
T2 - From Pathogenesis to Potential Molecular Therapies
AU - Di Vincenzo, Federica
AU - Yadid, Ylenia
AU - Petito, Valentina
AU - Emoli, Valeria
AU - Masi, Letizia
AU - Gerovska, Daniela
AU - Araúzo-Bravo, Marcos Jesus
AU - Gasbarrini, Antonio
AU - Regenberg, Birgitte
AU - Scaldaferri, Franco
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Inflammatory bowel diseases (IBD), including Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic multifactorial disorders which affect the gastrointestinal tract with variable extent. Despite extensive research, their etiology and exact pathogenesis are still unknown. Cell-free DNAs (cfDNAs) are defined as any DNA fragments which are free from the origin cell and able to circulate into the bloodstream with or without microvescicles. CfDNAs are now being increasingly studied in different human diseases, like cancer or inflammatory diseases. However, to date it is unclear how IBD etiology is linked to cfDNAs in plasma. Extrachromosomal circular DNA (eccDNA) are non-plasmidic, nuclear, circular and closed DNA molecules found in all eukaryotes tested. CfDNAs appear to play an important role in autoimmune diseases, inflammatory processes, and cancer; recently, interest has also grown in IBD, and their role in the pathogenesis of IBD has been suggested. We now suggest that eccDNAs also play a role in IBD. In this review, we have comprehensively collected available knowledge in literature regarding cfDNA, eccDNA, and structures involving them such as neutrophil extracellular traps and exosomes, and their role in IBD. Finally, we focused on old and novel potential molecular therapies and drug delivery systems, such as nanoparticles, for IBD treatment.
AB - Inflammatory bowel diseases (IBD), including Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic multifactorial disorders which affect the gastrointestinal tract with variable extent. Despite extensive research, their etiology and exact pathogenesis are still unknown. Cell-free DNAs (cfDNAs) are defined as any DNA fragments which are free from the origin cell and able to circulate into the bloodstream with or without microvescicles. CfDNAs are now being increasingly studied in different human diseases, like cancer or inflammatory diseases. However, to date it is unclear how IBD etiology is linked to cfDNAs in plasma. Extrachromosomal circular DNA (eccDNA) are non-plasmidic, nuclear, circular and closed DNA molecules found in all eukaryotes tested. CfDNAs appear to play an important role in autoimmune diseases, inflammatory processes, and cancer; recently, interest has also grown in IBD, and their role in the pathogenesis of IBD has been suggested. We now suggest that eccDNAs also play a role in IBD. In this review, we have comprehensively collected available knowledge in literature regarding cfDNA, eccDNA, and structures involving them such as neutrophil extracellular traps and exosomes, and their role in IBD. Finally, we focused on old and novel potential molecular therapies and drug delivery systems, such as nanoparticles, for IBD treatment.
KW - bioinformatics
KW - cell-free DNA
KW - cell-free nucleic acids
KW - cGAS-STING
KW - circular DNA
KW - inflammatory bowel disease
KW - microvescicles
KW - molecular therapies
KW - oligonucleotides
KW - TLR9
U2 - 10.3390/cells12151953
DO - 10.3390/cells12151953
M3 - Review
C2 - 37566032
AN - SCOPUS:85167618416
VL - 12
JO - Cells
JF - Cells
SN - 2073-4409
IS - 15
M1 - 1953
ER -
ID: 362899566