Lactate and Lactylation: Clinical Applications of Routine Carbon Source and Novel Modification in Human Diseases
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Lactate and Lactylation : Clinical Applications of Routine Carbon Source and Novel Modification in Human Diseases. / Wang, Zhimin; Hao, Dan; Zhao, Shuiying; Zhang, Ziyin; Zeng, Zhen; Wang, Xiao.
In: Molecular and Cellular Proteomics, Vol. 22, No. 10, 100641, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lactate and Lactylation
T2 - Clinical Applications of Routine Carbon Source and Novel Modification in Human Diseases
AU - Wang, Zhimin
AU - Hao, Dan
AU - Zhao, Shuiying
AU - Zhang, Ziyin
AU - Zeng, Zhen
AU - Wang, Xiao
N1 - Publisher Copyright: © 2023 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.
PY - 2023
Y1 - 2023
N2 - Cell metabolism generates numerous intermediate metabolites that could serve as feedback and feed-forward regulation substances for posttranslational modification. Lactate, a metabolic product of glycolysis, has recently been conceptualized to play a pleiotropic role in shaping cell identities through metabolic rewiring and epigenetic modifications. Lactate-derived carbons, sourced from glucose, mediate the crosstalk among glycolysis, lactate, and lactylation. Furthermore, the multiple metabolic fates of lactate make it an ideal substrate for metabolic imaging in clinical application. Several studies have identified the crucial role of protein lactylation in human diseases associated with cell fate determination, embryonic development, inflammation, neoplasm, and neuropsychiatric disorders. Herein, this review will focus on the metabolic fate of lactate-derived carbon to provide useful information for further research and therapeutic approaches in human diseases. We comprehensively discuss its role in reprogramming and modification during the regulation of glycolysis, the clinical translation prospects of the hyperpolarized lactate signal, lactyl modification in human diseases, and its application with other techniques and omics.
AB - Cell metabolism generates numerous intermediate metabolites that could serve as feedback and feed-forward regulation substances for posttranslational modification. Lactate, a metabolic product of glycolysis, has recently been conceptualized to play a pleiotropic role in shaping cell identities through metabolic rewiring and epigenetic modifications. Lactate-derived carbons, sourced from glucose, mediate the crosstalk among glycolysis, lactate, and lactylation. Furthermore, the multiple metabolic fates of lactate make it an ideal substrate for metabolic imaging in clinical application. Several studies have identified the crucial role of protein lactylation in human diseases associated with cell fate determination, embryonic development, inflammation, neoplasm, and neuropsychiatric disorders. Herein, this review will focus on the metabolic fate of lactate-derived carbon to provide useful information for further research and therapeutic approaches in human diseases. We comprehensively discuss its role in reprogramming and modification during the regulation of glycolysis, the clinical translation prospects of the hyperpolarized lactate signal, lactyl modification in human diseases, and its application with other techniques and omics.
U2 - 10.1016/j.mcpro.2023.100641
DO - 10.1016/j.mcpro.2023.100641
M3 - Journal article
C2 - 37678638
AN - SCOPUS:85175080522
VL - 22
JO - Molecular and Cellular Proteomics
JF - Molecular and Cellular Proteomics
SN - 1535-9476
IS - 10
M1 - 100641
ER -
ID: 372183555