Acyl-CoA binding proteins; structural and functional conservation over 2000 MYA.
Research output: Contribution to journal › Journal article › Research › peer-review
Besides serving as essential substrates for beta-oxidation and synthesis of triacylglycerols and more complex lipids like sphingolipids and sterol esters, long-chain fatty acyl-CoA esters are increasingly being recognized as important regulators of enzyme activities and gene transcription. Acyl-CoA binding protein, ACBP, has been proposed to play a pivotal role in the intracellular trafficking and utilization of long-chain fatty acyl-CoA esters. Depletion of acyl-CoA binding protein in yeast results in aberrant organelle morphology incl. fragmented vacuoles, multi-layered plasma membranes and accumulation of vesicles of variable sizes. In contrast to synthesis and turn-over of glycerolipids, the levels of very-long-chain fatty acids, long-chain bases and ceramide are severely affected by Acb1p depletion, suggesting that Acb1p, rather than playing a general role, serves specific roles in cellular lipid metabolism.
Udgivelsesdato: 2007-May
Udgivelsesdato: 2007-May
Original language | English |
---|---|
Journal | Molecular and Cellular Biochemistry |
Volume | 299 |
Issue number | 1-2 |
Pages (from-to) | 55-65 |
Number of pages | 10 |
ISSN | 0300-8177 |
DOIs | |
Publication status | Published - 2007 |
Bibliographical note
Keywords: Animals; Diazepam Binding Inhibitor; Humans; Phylogeny; Structure-Activity Relationship
ID: 2890706