Could Experimental Inflammation Provide Better Understanding of Migraines?

Research output: Contribution to journal › Review › Research › peer-review

Standard

Could Experimental Inflammation Provide Better Understanding of Migraines? / Reducha, Philip Victor; Edvinsson, Lars; Haanes, Kristian Agmund.

In: Cells, Vol. 11, No. 15, 2444, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Reducha, PV, Edvinsson, L & Haanes, KA 2022, 'Could Experimental Inflammation Provide Better Understanding of Migraines?', Cells, vol. 11, no. 15, 2444. https://doi.org/10.3390/cells11152444

APA

Reducha, P. V., Edvinsson, L., & Haanes, K. A. (2022). Could Experimental Inflammation Provide Better Understanding of Migraines? Cells, 11(15), [2444]. https://doi.org/10.3390/cells11152444

Vancouver

Reducha PV, Edvinsson L, Haanes KA. Could Experimental Inflammation Provide Better Understanding of Migraines? Cells. 2022;11(15). 2444. https://doi.org/10.3390/cells11152444

Author

Reducha, Philip Victor ; Edvinsson, Lars ; Haanes, Kristian Agmund. / Could Experimental Inflammation Provide Better Understanding of Migraines?. In: Cells. 2022 ; Vol. 11, No. 15.

Bibtex

@article{5a49f96ffef64ebfafa6c00fcd4fc630,
title = "Could Experimental Inflammation Provide Better Understanding of Migraines?",
abstract = "Migraines constitute a common neurological and headache disorder affecting around 15% of the world's population. In addition to other mechanisms, neurogenic neuroinflammation has been proposed to play a part in migraine chronification, which includes peripheral and central sensitization. There is therefore considerable evidence suggesting that inflammation in the intracranial meninges could be a key element in addition to calcitonin gene-related peptide (CGRP), leading to sensitization of trigeminal meningeal nociceptors in migraines. There are several studies that have utilized this approach, with a strong focus on using inflammatory animal models. Data from these studies show that the inflammatory process involves sensitization of trigeminovascular afferent nerve terminals. Further, by applying a wide range of different pharmacological interventions, insight has been gained on the pathways involved. Importantly, we discuss how animal models should be used with care and that it is important to evaluate outcomes in the light of migraine pathology.",
keywords = "inflammation, migraine, CGRP, CFA, inflammatory soup, TRIGEMINAL GANGLION NEURONS, GENE-RELATED PEPTIDE, MAGNETIC-RESONANCE-SPECTROSCOPY, CGRP RECEPTOR ANTAGONIST, RAT MODEL, CENTRAL SENSITIZATION, PLASMA EXTRAVASATION, ANIMAL-MODEL, MITOCHONDRIAL DYSFUNCTION, MENINGEAL NOCICEPTORS",
author = "Reducha, {Philip Victor} and Lars Edvinsson and Haanes, {Kristian Agmund}",
year = "2022",
doi = "10.3390/cells11152444",
language = "English",
volume = "11",
journal = "Cells",
issn = "2073-4409",
publisher = "MDPI AG",
number = "15",

}

RIS

TY - JOUR

T1 - Could Experimental Inflammation Provide Better Understanding of Migraines?

AU - Reducha, Philip Victor

AU - Edvinsson, Lars

AU - Haanes, Kristian Agmund

PY - 2022

Y1 - 2022

N2 - Migraines constitute a common neurological and headache disorder affecting around 15% of the world's population. In addition to other mechanisms, neurogenic neuroinflammation has been proposed to play a part in migraine chronification, which includes peripheral and central sensitization. There is therefore considerable evidence suggesting that inflammation in the intracranial meninges could be a key element in addition to calcitonin gene-related peptide (CGRP), leading to sensitization of trigeminal meningeal nociceptors in migraines. There are several studies that have utilized this approach, with a strong focus on using inflammatory animal models. Data from these studies show that the inflammatory process involves sensitization of trigeminovascular afferent nerve terminals. Further, by applying a wide range of different pharmacological interventions, insight has been gained on the pathways involved. Importantly, we discuss how animal models should be used with care and that it is important to evaluate outcomes in the light of migraine pathology.

AB - Migraines constitute a common neurological and headache disorder affecting around 15% of the world's population. In addition to other mechanisms, neurogenic neuroinflammation has been proposed to play a part in migraine chronification, which includes peripheral and central sensitization. There is therefore considerable evidence suggesting that inflammation in the intracranial meninges could be a key element in addition to calcitonin gene-related peptide (CGRP), leading to sensitization of trigeminal meningeal nociceptors in migraines. There are several studies that have utilized this approach, with a strong focus on using inflammatory animal models. Data from these studies show that the inflammatory process involves sensitization of trigeminovascular afferent nerve terminals. Further, by applying a wide range of different pharmacological interventions, insight has been gained on the pathways involved. Importantly, we discuss how animal models should be used with care and that it is important to evaluate outcomes in the light of migraine pathology.

KW - inflammation

KW - migraine

KW - CGRP

KW - CFA

KW - inflammatory soup

KW - TRIGEMINAL GANGLION NEURONS

KW - GENE-RELATED PEPTIDE

KW - MAGNETIC-RESONANCE-SPECTROSCOPY

KW - CGRP RECEPTOR ANTAGONIST

KW - RAT MODEL

KW - CENTRAL SENSITIZATION

KW - PLASMA EXTRAVASATION

KW - ANIMAL-MODEL

KW - MITOCHONDRIAL DYSFUNCTION

KW - MENINGEAL NOCICEPTORS

U2 - 10.3390/cells11152444

DO - 10.3390/cells11152444

M3 - Review

C2 - 35954288

VL - 11

JO - Cells

JF - Cells

SN - 2073-4409

IS - 15

M1 - 2444

ER -

ID: 317444692