Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals
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Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals. / Itoigawa, Akihiro; Hayakawa, Takashi; Zhou, Yang; Manning, Adrian D.; Zhang, Guojie; Grutzner, Frank; Imai, Hiroo.
In: Molecular Biology and Evolution, Vol. 39, No. 6, msac107, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals
AU - Itoigawa, Akihiro
AU - Hayakawa, Takashi
AU - Zhou, Yang
AU - Manning, Adrian D.
AU - Zhang, Guojie
AU - Grutzner, Frank
AU - Imai, Hiroo
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.
PY - 2022
Y1 - 2022
N2 - Egg-laying mammals (monotremes) are a sister clade of therians (placental mammals and marsupials) and a key clade to understand mammalian evolution. They are classified into platypus and echidna, which exhibit distinct ecological features such as habitats and diet. Chemosensory genes, which encode sensory receptors for taste and smell, are believed to adapt to the individual habitats and diet of each mammal. In this study, we focused on the molecular evolution of bitter taste receptors (TAS2Rs) in monotremes. The sense of bitter taste is important to detect potentially harmful substances. We comprehensively surveyed agonists of all TAS2Rs in platypus (Ornithorhynchus anatinus) and short-beaked echidna (Tachyglossus aculeatus) and compared their functions with orthologous TAS2Rs of marsupial and placental mammals (i.e., therians). As results, the agonist screening revealed that the deorphanized monotreme receptors were functionally diversified. Platypus TAS2Rs had broader receptive ranges of agonists than those of echidna TAS2Rs. While platypus consumes a variety of aquatic invertebrates, echidna mainly consumes subterranean social insects (ants and termites) as well as other invertebrates. This result indicates that receptive ranges of TAS2Rs could be associated with feeding habits in monotremes. Furthermore, some orthologous receptors in monotremes and therians responded to β-glucosides, which are feeding deterrents in plants and insects. These results suggest that the ability to detect β-glucosides and other substances might be shared and ancestral among mammals.
AB - Egg-laying mammals (monotremes) are a sister clade of therians (placental mammals and marsupials) and a key clade to understand mammalian evolution. They are classified into platypus and echidna, which exhibit distinct ecological features such as habitats and diet. Chemosensory genes, which encode sensory receptors for taste and smell, are believed to adapt to the individual habitats and diet of each mammal. In this study, we focused on the molecular evolution of bitter taste receptors (TAS2Rs) in monotremes. The sense of bitter taste is important to detect potentially harmful substances. We comprehensively surveyed agonists of all TAS2Rs in platypus (Ornithorhynchus anatinus) and short-beaked echidna (Tachyglossus aculeatus) and compared their functions with orthologous TAS2Rs of marsupial and placental mammals (i.e., therians). As results, the agonist screening revealed that the deorphanized monotreme receptors were functionally diversified. Platypus TAS2Rs had broader receptive ranges of agonists than those of echidna TAS2Rs. While platypus consumes a variety of aquatic invertebrates, echidna mainly consumes subterranean social insects (ants and termites) as well as other invertebrates. This result indicates that receptive ranges of TAS2Rs could be associated with feeding habits in monotremes. Furthermore, some orthologous receptors in monotremes and therians responded to β-glucosides, which are feeding deterrents in plants and insects. These results suggest that the ability to detect β-glucosides and other substances might be shared and ancestral among mammals.
KW - Animals
KW - Eutheria/genetics
KW - Female
KW - Mammals/genetics
KW - Placenta
KW - Platypus/genetics
KW - Pregnancy
KW - Tachyglossidae
KW - Taste
U2 - 10.1093/molbev/msac107
DO - 10.1093/molbev/msac107
M3 - Journal article
C2 - 35652727
VL - 39
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
SN - 0737-4038
IS - 6
M1 - msac107
ER -
ID: 310502831