The role of half-transporters in multidrug resistance

Research output: Contribution to journal › Journal article › Research › peer-review

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The role of half-transporters in multidrug resistance. / Bates, S E; Robey, R; Miyake, K; Rao, K; Ross, D D; Litman, Thomas.

In: Journal of Bioenergetics and Biomembranes, Vol. 33, No. 6, 12.2001, p. 503-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bates, SE, Robey, R, Miyake, K, Rao, K, Ross, DD & Litman, T 2001, 'The role of half-transporters in multidrug resistance', Journal of Bioenergetics and Biomembranes, vol. 33, no. 6, pp. 503-11.

APA

Bates, S. E., Robey, R., Miyake, K., Rao, K., Ross, D. D., & Litman, T. (2001). The role of half-transporters in multidrug resistance. Journal of Bioenergetics and Biomembranes, 33(6), 503-11.

Vancouver

Bates SE, Robey R, Miyake K, Rao K, Ross DD, Litman T. The role of half-transporters in multidrug resistance. Journal of Bioenergetics and Biomembranes. 2001 Dec;33(6):503-11.

Author

Bates, S E ; Robey, R ; Miyake, K ; Rao, K ; Ross, D D ; Litman, Thomas. / The role of half-transporters in multidrug resistance. In: Journal of Bioenergetics and Biomembranes. 2001 ; Vol. 33, No. 6. pp. 503-11.

Bibtex

@article{aba56187e10d45f4b64139fbaeeba0d7,
title = "The role of half-transporters in multidrug resistance",
abstract = "ATP-binding cassette proteins comprise a superfamily of transporter proteins, a subset of which have been implicated in multidrug resistance. Although P-glycoprotein was described over 15 years ago, the recent expansion in the number of transporters identified has prompted renewed interest in the role of drug transporters in clinical drug resistance. These newly identified transporters include additional members of the MRP family, ABC2, and a new half-transporter, MXR/BCRP/ABCP1. This half-transporter confers high levels of resistance to mitoxantrone, anthracyclines, and the camptothecins SN-38 and topotecan. At 72 kDa, MXR localizes to the plasma membrane in cells which highly overexpress the protein either through gene amplification or though gene rearrangement. Future studies will be aimed at identifying an inhibitor, and attempting to translate recognition of this new transporter into a target for anticancer treatment.",
keywords = "Animals, Drug Resistance, Multiple, Humans, Multidrug Resistance-Associated Proteins",
author = "Bates, {S E} and R Robey and K Miyake and K Rao and Ross, {D D} and Thomas Litman",
year = "2001",
month = dec,
language = "English",
volume = "33",
pages = "503--11",
journal = "Journal of Bioenergetics and Biomembranes",
issn = "0145-479X",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - The role of half-transporters in multidrug resistance

AU - Bates, S E

AU - Robey, R

AU - Miyake, K

AU - Rao, K

AU - Ross, D D

AU - Litman, Thomas

PY - 2001/12

Y1 - 2001/12

N2 - ATP-binding cassette proteins comprise a superfamily of transporter proteins, a subset of which have been implicated in multidrug resistance. Although P-glycoprotein was described over 15 years ago, the recent expansion in the number of transporters identified has prompted renewed interest in the role of drug transporters in clinical drug resistance. These newly identified transporters include additional members of the MRP family, ABC2, and a new half-transporter, MXR/BCRP/ABCP1. This half-transporter confers high levels of resistance to mitoxantrone, anthracyclines, and the camptothecins SN-38 and topotecan. At 72 kDa, MXR localizes to the plasma membrane in cells which highly overexpress the protein either through gene amplification or though gene rearrangement. Future studies will be aimed at identifying an inhibitor, and attempting to translate recognition of this new transporter into a target for anticancer treatment.

AB - ATP-binding cassette proteins comprise a superfamily of transporter proteins, a subset of which have been implicated in multidrug resistance. Although P-glycoprotein was described over 15 years ago, the recent expansion in the number of transporters identified has prompted renewed interest in the role of drug transporters in clinical drug resistance. These newly identified transporters include additional members of the MRP family, ABC2, and a new half-transporter, MXR/BCRP/ABCP1. This half-transporter confers high levels of resistance to mitoxantrone, anthracyclines, and the camptothecins SN-38 and topotecan. At 72 kDa, MXR localizes to the plasma membrane in cells which highly overexpress the protein either through gene amplification or though gene rearrangement. Future studies will be aimed at identifying an inhibitor, and attempting to translate recognition of this new transporter into a target for anticancer treatment.

KW - Animals

KW - Drug Resistance, Multiple

KW - Humans

KW - Multidrug Resistance-Associated Proteins

M3 - Journal article

C2 - 11804192

VL - 33

SP - 503

EP - 511

JO - Journal of Bioenergetics and Biomembranes

JF - Journal of Bioenergetics and Biomembranes

SN - 0145-479X

IS - 6

ER -

ID: 119646846