Type XXIII collagen
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Type XXIII collagen. / Crespo-Bravo, M.; Kehlet, S. N.; Jessen, H.; Karsdal, M. A.
Biochemistry of Collagens, Laminins and Elastin: Structure, Function and Biomarkers. 3. ed. Elsevier, 2024. p. 199-202.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Type XXIII collagen
AU - Crespo-Bravo, M.
AU - Kehlet, S. N.
AU - Jessen, H.
AU - Karsdal, M. A.
N1 - Publisher Copyright: © 2024 Elsevier Inc. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Type XXIII collagen is a type II transmembrane collagen found in healthy human and mouse tissues of the lung, cornea, skin, tendon, amnion, and to a lesser extent in the kidney and placenta. Currently, its function is unknown; however, type XXIII collagen is a component of many epithelia and expressed on epithelial cell surfaces, suggesting a role in the formation or maintenance of cell-cell contacts or the polarization of epithelial cells. Type XXIII collagen levels in patient samples have been proposed as a new biomarker of prostate cancer progression and recurrence. Type XXIII collagen has been detected in urine samples of prostate cancer and non-small-cell lung cancer patients and can discriminate between controls and cancer patients, indicating a potential role as a new diagnostic tool in certain types of cancer. There are currently no mutations in humans or mice associated with biological functions; no biomarkers have been put forward.
AB - Type XXIII collagen is a type II transmembrane collagen found in healthy human and mouse tissues of the lung, cornea, skin, tendon, amnion, and to a lesser extent in the kidney and placenta. Currently, its function is unknown; however, type XXIII collagen is a component of many epithelia and expressed on epithelial cell surfaces, suggesting a role in the formation or maintenance of cell-cell contacts or the polarization of epithelial cells. Type XXIII collagen levels in patient samples have been proposed as a new biomarker of prostate cancer progression and recurrence. Type XXIII collagen has been detected in urine samples of prostate cancer and non-small-cell lung cancer patients and can discriminate between controls and cancer patients, indicating a potential role as a new diagnostic tool in certain types of cancer. There are currently no mutations in humans or mice associated with biological functions; no biomarkers have been put forward.
KW - Cancer
KW - COL23A1
KW - Collagen
KW - Integrin α2β1
KW - NSCLC
KW - Prostate cancer
KW - Serum biomarker
KW - Transmembrane collagen
KW - Type XXIII collagen
KW - Urine biomarker
U2 - 10.1016/B978-0-443-15617-5.00009-3
DO - 10.1016/B978-0-443-15617-5.00009-3
M3 - Book chapter
AN - SCOPUS:85184117123
SN - 9780443156182
SP - 199
EP - 202
BT - Biochemistry of Collagens, Laminins and Elastin
PB - Elsevier
ER -
ID: 391158875