Viral leads for chemokine-modulatory drugs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Viral leads for chemokine-modulatory drugs. / Lindow, Morten; Lüttichau, Hans Rudolf; Schwartz, Thue W.

In: TIPS - Trends in Pharmacological Sciences, Vol. 24, No. 3, 2003, p. 126-30.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lindow, M, Lüttichau, HR & Schwartz, TW 2003, 'Viral leads for chemokine-modulatory drugs', TIPS - Trends in Pharmacological Sciences, vol. 24, no. 3, pp. 126-30.

APA

Lindow, M., Lüttichau, H. R., & Schwartz, T. W. (2003). Viral leads for chemokine-modulatory drugs. TIPS - Trends in Pharmacological Sciences, 24(3), 126-30.

Vancouver

Lindow M, Lüttichau HR, Schwartz TW. Viral leads for chemokine-modulatory drugs. TIPS - Trends in Pharmacological Sciences. 2003;24(3):126-30.

Author

Lindow, Morten ; Lüttichau, Hans Rudolf ; Schwartz, Thue W. / Viral leads for chemokine-modulatory drugs. In: TIPS - Trends in Pharmacological Sciences. 2003 ; Vol. 24, No. 3. pp. 126-30.

Bibtex

@article{91f2d69074c211dbbee902004c4f4f50,
title = "Viral leads for chemokine-modulatory drugs",
abstract = "The chemokine system, which controls leukocyte trafficking, provides several potentially very attractive anti-inflammatory drug targets. However, the complexity and redundancy of this system makes it very difficult to exploit through classical drug discovery. Despite this, viruses have millions of years of experience in manipulating this system. For example, virally encoded {"}biopharmaceuticals{"}--chemokines and chemokine binding proteins--demonstrate the effectiveness of blocking a carefully selected group of chemokine receptors and how the local immune response can be changed from one dominated by Th1 cells to one dominated by Th2 cells by targeting specific chemokine receptors. The crucial importance of the binding of chemokines to glycosaminoglycans to produce their effects is also highlighted by viruses that produce binding proteins to disrupt the gradient of chemokines, which guides the direction leukocyte migration.",
author = "Morten Lindow and L{\"u}ttichau, {Hans Rudolf} and Schwartz, {Thue W}",
note = "Keywords: Animals; Biopharmaceutics; Humans; Receptors, Chemokine; Virus Diseases; Viruses",
year = "2003",
language = "English",
volume = "24",
pages = "126--30",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Ltd. * Trends Journals",
number = "3",

}

RIS

TY - JOUR

T1 - Viral leads for chemokine-modulatory drugs

AU - Lindow, Morten

AU - Lüttichau, Hans Rudolf

AU - Schwartz, Thue W

N1 - Keywords: Animals; Biopharmaceutics; Humans; Receptors, Chemokine; Virus Diseases; Viruses

PY - 2003

Y1 - 2003

N2 - The chemokine system, which controls leukocyte trafficking, provides several potentially very attractive anti-inflammatory drug targets. However, the complexity and redundancy of this system makes it very difficult to exploit through classical drug discovery. Despite this, viruses have millions of years of experience in manipulating this system. For example, virally encoded "biopharmaceuticals"--chemokines and chemokine binding proteins--demonstrate the effectiveness of blocking a carefully selected group of chemokine receptors and how the local immune response can be changed from one dominated by Th1 cells to one dominated by Th2 cells by targeting specific chemokine receptors. The crucial importance of the binding of chemokines to glycosaminoglycans to produce their effects is also highlighted by viruses that produce binding proteins to disrupt the gradient of chemokines, which guides the direction leukocyte migration.

AB - The chemokine system, which controls leukocyte trafficking, provides several potentially very attractive anti-inflammatory drug targets. However, the complexity and redundancy of this system makes it very difficult to exploit through classical drug discovery. Despite this, viruses have millions of years of experience in manipulating this system. For example, virally encoded "biopharmaceuticals"--chemokines and chemokine binding proteins--demonstrate the effectiveness of blocking a carefully selected group of chemokine receptors and how the local immune response can be changed from one dominated by Th1 cells to one dominated by Th2 cells by targeting specific chemokine receptors. The crucial importance of the binding of chemokines to glycosaminoglycans to produce their effects is also highlighted by viruses that produce binding proteins to disrupt the gradient of chemokines, which guides the direction leukocyte migration.

M3 - Journal article

C2 - 12628357

VL - 24

SP - 126

EP - 130

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 3

ER -

ID: 78133