- 2017
- Published
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas
Mohammad, F., Weissmann, S., Leblanc, B. O., Pandey, D. P., Højfeldt, J. W., Comet, I., Zheng, C., Johansen, Jens Vilstrup, Rapin, N. P. J., Porse, Bo Torben, Tvardovskiy, A., Jensen, O. N., Olaciregui, N. G., Lavarino, C., Suñol, M., de Torres, C., Mora, J., Carcaboso, A. M. & Helin, K., Apr 2017, In: Nature Medicine. 23, 4, p. 483-492 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sphingosine-1-phosphate signaling in inflammatory bowel disease
Nielsen, Ole Haagen, Li, Yuan, Lindbom, B. J. & Coskun, M., Apr 2017, In: Trends in Molecular Medicine. 23, 4, p. 362-374 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Molecular clocks indicate turnover and diversification of modern coleoid cephalopods during the Mesozoic Marine Revolution
Tanner, A. R., Fuchs, D., Winkelmann, I. E. H., Gilbert, M Thomas P, Pankey, M. S., Oliveira Ribeiro, Â. M., Kocot, K. M., Halanych, K. M., Oakley, T. H., Rodrigues da Fonseca, Rute Andreia, Pisani, D. & Vinther, J., 15 Mar 2017, In: Proceedings of the Royal Society B: Biological Sciences. 284, 1850, 7 p., 20162818.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extinctions, genetic erosion and conservation options for the black rhinoceros (Diceros bicornis)
Moodley, Y., Russo, I. M., Dalton, D. L., Kotzé, A., Muya, S., Haubensak, P., Bálint, B., Munimanda, G. K., Deimel, C., Setzer, A., Dicks, K., Herzig-Straschil, B., Kalthoff, D. C., Siegismund, Hans Redlef, Robovský, J., O'Donoghue, P. & Bruford, M. W., 8 Feb 2017, In: Scientific Reports. 7, 16 p., 41417.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Marine genomics: news and views
Oliveira Ribeiro, Â. M., Foote, A. D., Kupczok, A., Frazão, B., Limborg, Morten Tønsberg, Piñeiro, R., Abalde, S., Rocha, S. & Rodrigues da Fonseca, Rute Andreia, Feb 2017, In: Marine Genomics. 31, p. 1-8 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Novel targeted therapies for inflammatory bowel disease
Coskun, M., Vermeire, S. & Nielsen, Ole Haagen, Feb 2017, In: Trends in Pharmacological Sciences. 38, 2, p. 127-142 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The effect of an extreme and prolonged population bottleneck on patterns of deleterious variation: insights from the Greenlandic Inuit
Pedersen, C. T., Lohmueller, K. E., Grarup, Niels, Bjerregaard, P., Hansen, Torben, Siegismund, Hans Redlef, Moltke, Ida & Albrechtsen, Anders, Feb 2017, In: Genetics. 205, 2, p. 787-801 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types
Ecker, S., Chen, L., Pancaldi, V., Bagger, F. O., Fernández, J. M., Carrillo de Santa Pau, E., Juan, D., Mann, A. L., Watt, S., Casale, F. P., Sidiropoulos, N., Rapin, N. P. J-P., Merkel, A., Stunnenberg, H. G., Stegle, O., Frontini, M., Downes, K., Pastinen, T., Kuijpers, T. W., Rico, D. & 50 others, , 26 Jan 2017, In: Genome Biology. 18, 1, 17 p., 18.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysing human genomes at different scales
Liu, S., 2017, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion
Skov, L., Schierup, M. H., Danish Pan Genome Consortium, D. P. G. C., Sørensen, L. M., Petersen, Bent, Sibbesen, Jonas Andreas, Liu, S., Belling, K. G., Have, C. T., Bork-Jensen, J., Hansen, Torben, Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Rasmussen, Simon, Kristiansen, Karsten & Brunak, Søren, 2017, In: PLOS Genetics. 13, 8, p. e1006834Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Archaic adaptive introgression in TBX15/WARS2
Racimo, Fernando, Gokhman, D., Fumagalli, M., Ko, A., Hansen, Torben, Moltke, Ida, Albrechtsen, Anders, Carmel, L., Huerta-Sánchez, E. & Nielsen, Rasmus, 2017, In: Molecular Biology and Evolution. 34, 3, p. 509-524 16 p., msw283.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deep Recurrent Conditional Random Field Network for Protein Secondary Prediction
Johansen, A. R., Sønderby, C. K., Sønderby, S. K. & Winther, O., 2017, ACM-BCB '17: Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. p. 73-78 6 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
Demographic inferences from large-scale NGS data
Pedersen, C. T., 2017, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
Discrete structural dynamics of pseudo-palindromic motifs control DNA binding of bacterial toxin-antitoxin complexes
Brodersen, D. E., Bendtsen, K. L., Xu, K., Luckmann, M., Winther, K. S., Shah, S. A. & Pedersen, C. N. S., 2017, In: F A S E B Journal. 31, S1, 1 p., 777.2.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Diversity of nature's assembly lines - recent discoveries in non-ribosomal peptide synthesis
Payne, J. A. E., Schoppet, M., Hansen, M. H. & Cryle, M. J., 2017, In: Molecular BioSystems. 13, 1, p. 9-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic screening of the FLCN gene identify six novel variants and a Danish founder mutation
Rossing, M., Albrechtsen, Anders, Skytte, A., Jensen, U. B., Ousager, L. B., Gerdes, Anne-Marie Axø, Nielsen, Finn Cilius & Hansen, T. V. O., 2017, In: Journal of Human Genetics. 62, p. 151-157 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of gene transcription start sites and enhancers responding to pulmonary carbon nanotube exposure in Vivo
Lange, Jette Bornholdt, Saber, A. T., Lilje, B., Boyd, M., Jørgensen, M., Chen, Y., Vitezic, M., Jacobsen, N. R., Poulsen, S. S., Berthing, T., Bressendorff, Simon, Vitting-Seerup, K., Andersson, Robin, Hougaard, K. S., Yauk, C. L., Halappanavar, S., Wallin, E. H. R., Vogel, U. & Sandelin, Albin Gustav, 2017, In: A C S Nano. 11, 4, p. 3597-3613 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating membrane-bound Argonaute functions in Arabidopsis
Barghetti, A., 2017, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression
Pinto, R., Hansen, Lars, Hintze, John, Almeida, R., Larsen, S., Coskun, M., Davidsen, J., Mitchelmore, C., David, L., Troelsen, J. T. & Bennett, Eric Paul, 2017, In: Nucleic Acids Research. 45, 13, 15 p., e123.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of laminin γ2 expression by CDX2 in colonic epithelial cells is impaired during active inflammation
Coskun, M., Soendergaard, C., Joergensen, S., Dahlgaard, K., Riis, Lene Buhl, Nielsen, Ole Haagen, Sandelin, Albin Gustav & Troelsen, J. T., 2017, In: Journal of Cellular Biochemistry. 118, 2, p. 298-307 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Relation between NOD2 genotype and changes in innate signaling in Crohn's disease on mRNA and miRNA levels
Chen, Y., Salem, M., Boyd, M., Lange, Jette Bornholdt, Li, Yuan, Coskun, M., Seidelin, Jakob Benedict, Sandelin, Albin Gustav & Nielsen, Ole Haagen, 2017, In: npj Genomic Medicine. 2, 11 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequence Analysis
Sønderby, S. K., 2017, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference
Sørensen, L. M., Jensen, J. M., Petersen, B., Sibbesen, J. A., Liu, S., Villesen, P., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R., Ye, W., Rao, J., Guo, X. & 39 others, , 2017, In: Nature. 548, 7665, p. 87-91 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Structures and Interactions of Proteins in the Brain: The Interaction Between LRP1 and Aß & Structure and Self-Assembly of Arc
Nielsen, L. D., 2017, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
The Bipolar Illness Onset study: research protocol for the BIO cohort study
Kessing, Lars Vedel, Munkholm, K., Faurholt-Jepsen, M., Miskowiak, Kamilla, Nielsen, L. B., Frikke-Schmidt, Ruth, Ekstrøm, Claus Thorn, Winther, Ole, Pedersen, Bente Klarlund, Poulsen, Henrik Enghusen, McIntyre, R. S., Kapczinski, F., Gattaz, W. F., Bardram, J., Frost, M., Mayora, O., Knudsen, Gitte Moos, Phillips, M. & Vinberg, Maj, 2017, In: BMJ Open. 7, 6, 12 p., e015462.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Toxin inhibition in C. crescentus VapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding
Bendtsen, K. L., Xu, K., Luckmann, M., Winther, K. S., Shah, S. A., Pedersen, C. N. S. & Brodersen, D. E., 2017, In: Nucleic Acids Research. 45, 5, p. 2875-2886 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional dynamics during human adipogenesis and its link to adipose morphology and distribution
Ehrlund, A., Mejhert, N., Björk, C., Andersson, Robin, Kulyté, A., Åström, G., Itoh, M., Kawaji, H., Lassmann, T., Daub, C. O., Carninci, P., Forrest, A. R. R., Hayashizaki, Y., Sandelin, Albin Gustav, Ingelsson, E., FANTOM Consortium, Rydén, M., Laurencikiene, J., Arner, P. & Arner, E., 2017, In: Diabetes. 66, 1, p. 218-230 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals
Lizio, M., Harshbarger, J., Abugessaisa, I., Noguchi, S., Kondo, A., Severin, J., Mungall, C., Arenillas, D., Mathelier, A., Medvedeva, Y. A., Lennartsson, A., Drabløs, F., Ramilowski, J. A., Rackham, O., Gough, J., Andersson, R., Sandelin, A. G., Ienasescu, H-I., Ono, H., Bono, H. & 5 others, , 2017, In: Nucleic Acids Research. 45, D1, p. D737-D743 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization
Damas, N. D., Marcatti, M., Côme, Christophe Roger Michel, Christensen, L., Nielsen, M. M., Baumgartner, R., Gylling, H. M., Maglieri, G., Friis, Carsten, Seemann, Ernst Stefan, Rapin, N., Thézenas, S., Vang, S., Ørntoft, T., Andersen, C. L., Pedersen, J. S. & Lund, Anders H., 22 Dec 2016, In: Nature Communications. 7, 14 p., 13875.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a nuclear exosome decay pathway for processed transcripts
Meola, N., Domanski, M., Karadoulama, Evdoxia, Chen, Y., Gentil, C. A. J., Pultz, D., Vitting-Seerup, K., Lykke-Andersen, S., Andersen, J. S., Sandelin, Albin Gustav & Jensen, T. H., 3 Nov 2016, In: Molecular Cell. 64, 3, p. 520-533 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients
Urup, T., Michaelsen, Signe Regner, Olsen, L. R., Toft, A., Christensen, I. J., Grunnet, K., Winther, Ole, Broholm, H., Kosteljanetz, M., Issazadeh-Navikas, Shohreh, Poulsen, H. S. & Lassen, Ulrik Niels, Oct 2016, In: Molecular Oncology. 10, 8, p. 1160-1168Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis
Bagger, F. O., Sasivarevic, D., Hadi Sohi, S., Laursen, L. G., Pundhir, Sachin, Sønderby, C. K., Winther, Ole, Rapin, N. & Porse, Bo Torben, 4 Jan 2016, In: Nucleic Acids Research. 44, D1, p. D917-24 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genomic history of aboriginal Australia
Malaspinas, A. S., Westaway, M. C., Muller, C. E., Sousa, V. C., Lao, O., Alves, I., Bergström, A., Athanasiadis, G., Cheng, J. Y., Crawford, J. E., Heupink, T. H., Macholdt, E., Peischl, S., Rasmussen, S., Schiffels, S., Subramanian, S., Wright, J. L., Albrechtsen, A., Barbieri, C., Dupanloup, I. & 55 others, , 2016, In: Nature. 538, 7624, p. 207-214 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AdapterRemoval v2: rapid adapter trimming, identification, and read merging
Schubert, Mikkel, Lindgreen, S. & Orlando, L. A. A., 2016, In: BMC Research Notes. 9, 7 p., 88.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An easy method for plant polysome profiling
Lecampion, C., Floris, M. H. J., Fantino, J. R., Robaglia, C. & Laloi, C., 2016, In: Journal of Visualized Experiments. 2016, 114, e54231.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling
Bagger, F. O., Bruedigam, C. & Lane, S. W., 2016, In: Genomics Data. 7, p. 275-280 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autoencoding beyond pixels using a learned similarity metric
Larsen, A. B. L., Sønderby, S. K., Larochelle, H. & Winther, Ole, 2016, Proceedings of The 33rd International Conference on Machine Learning. Balcan, M. F. & Weinberger, K. Q. (eds.). p. 1558–1566 9 p. (JMLR: Workshop and Conference Proceedings, Vol. 48).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation
Feng, Y., Vlassis, A., Roques, C., Lalonde, M. E., Gonzalez Aguilera, C., Lambert, J. P., Lee, S., Zhao, X., Alabert, C., Johansen, Jens Vilstrup, Paquet, E., Yang, X. J., Gingras, A. C., Côté, J. & Groth, Anja, 2016, In: EMBO Journal. 35, 2, p. 176-192 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bayesian inference of protein ensembles from SAXS data
Antonov, L. D., Olsson, S., Boomsma, Wouter & Hamelryck, Thomas Wim, 2016, In: Physical Chemistry Chemical Physics. 18, 8, p. 5832-5838 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizing leader sequences of CRISPR loci
Alkhnbashi, O., Shah, S. A., Garrett, Roger Antony, Saunders, S. J., Costa, F. & Backofen, R., 2016, In: Bioinformatics. 32, 17, p. i576-i585 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chimpanzee genomic diversity reveals ancient admixture with bonobos
de Manuel, M., Kuhlwilm, M., Frandsen, P., Sousa, V. C., Desai, T., Prado-Martinez, J., Hernandez-Rodriguez, J., Dupanloup, I., Lao, O., Hallast, P., Schmidt, J. M., Heredia-Genestar, J. M., Benazzo, A., Barbujani, G., Peter, B. M., Kuderna, L. F. K., Casals, F., Angedakin, S., Arandjelovic, M., Boesch, C. & 17 others, , 2016, In: Science. 354, 6311, p. 477-481 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating cytokines and cytokine receptors in infliximab treatment failure due to TNF-α independent Crohn disease
Steenholdt, Casper, Coskun, M., Buhl, S., Bendtzen, K., Ainsworth, M. A., Brynskov, J. & Nielsen, Ole Haagen, 2016, In: Medicine (Baltimore). 95, 16, 8 p., e3417.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coalescent inference using serially sampled, high-throughput sequencing data from intrahost HIV infection
Dialdestoro, K., Sibbesen, Jonas Andreas, Sørensen, L. M., Raghwani, J., Gall, A., Kellam, P., Pybus, O. G., Hein, J. & Jenkins, P. A., 2016, In: Genetics (Print). 202, 4, p. 1449-1472 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combined transcriptomic and proteomic analysis of the posterior salivary gland from the southern blue-ringed octopus and the southern sand octopus
Whitelaw, B. L., Strugnell, J. M., Faou, P., Rodrigues da Fonseca, Rute Andreia, Hall, N. E., Norman, M., Finn, J. & Cooke, I. R., 2016, In: Journal of Proteome Research. 15, 9, p. 3284-3297 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative analysis of complete mitochondrial genomes suggests that relaxed purifying selection is driving high nonsynonymous evolutionary rate of the NADH2 gene in whitefish (Coregonus ssp.)
Jacobsen, M. W., Rodrigues da Fonseca, Rute Andreia, Bernatchez, L. & Hansen, M. M., 2016, In: Molecular Phylogenetics and Evolution. 95, p. 161-170 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Computational Investigations of Post-Transcriptional Regulation: The Intricate Dependency of MicroRNA Regulation on RNA-Binding Proteins
Rasmussen, S. H., 2016, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template
Johansson, Kristoffer Enøe, Johansen, Nicolai Tidemand, Christensen, S., Horowitz, S., Bardwell, J. C. A., Olsen, Johan Gotthardt, Willemoës, Martin, Lindorff-Larsen, Kresten, Ferkinghoff-Borg, J., Hamelryck, Thomas Wim & Winther, Jakob R., 2016, In: Journal of Molecular Biology. 428, 21, p. 4361-4377 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing
Rukov, J. L., Gravesen, Eva, Mace, M. L., Hofman-Bang, J., Vinther, Jeppe, Andersen, C. B., Lewin, E. & Ølgaard, Klaus, 2016, In: American Journal of Physiology: Renal Physiology. 310, 6, p. F477-F491 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Estimating IBD tracts from low coverage NGS data
Vieira, Filipe Garrett, Albrechtsen, Anders & Nielsen, Rasmus, 2016, In: Bioinformatics. 32, 14, p. 2096-2102 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fast and sensitive taxonomic classification for metagenomics with Kaiju
Menzel, P., Ng, K. L. & Krogh, Anders, 2016, In: Nature Communications. 7, 9 p., 11257.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic consequences of human forest exploitation in two colobus monkeys in Guinea Bissau
Minhos, T., Chikhi, L., Sousa, C., Vicente, L. M., da Silva, M. F., Heller, Rasmus, Casanova, C. & Bruford, M. W., 2016, In: Biological Conservation. 194, p. 194-208 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetics of Type 2 diabetes: the power of isolated populations
Lepola, Mette Andersen, Pedersen, C. T., Moltke, Ida, Hansen, Torben, Albrechtsen, Anders & Grarup, Niels, 2016, In: Current Diabetes Reports. 16, 7, 9 p., 65.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide single nucleotide polymorphism (SNP) identification and characterization in a non-model organism, the African buffalo (Syncerus caffer), using next generation sequencing
Smitz, N., Van Hooft, P., Heller, Rasmus, Cornélis, D., Chardonnet, P., Kraus, R., Greyling, B., Crooijmans, R., Groenen, M. & Michaux, J., 2016, In: Mammalian Biology. 81, 6, p. 595-603 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of novel genetic determinants of erythrocyte membrane fatty acid composition among Greenlanders
Lepola, Mette Andersen, Jørsboe, E., Sandholt, C. H., Grarup, Niels, Jørgensen, M. E., Færgeman, N. J., Bjerregaard, P., Pedersen, Oluf Borbye, Moltke, Ida, Hansen, Torben & Albrechtsen, Anders, 2016, In: P L o S Genetics. 12, 6, 19 p., e1006119.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Iron replacement therapy: do we need new guidelines?
Nielsen, Ole Haagen, Coskun, M. & Weiss, G., 2016, In: Current Opinion in Gastroenterology. 32, 2, p. 128-135 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Isolation and characterization of the first Xylanolytic hyperthermophilic euryarchaeon Thermococcus sp strain 2319x1 and its unusual multidomain glycosidase
Gavrilov, S. N., Stracke, C., Jensen, K., Menzel, P., Kallnik, V., Slesarev, A., Sokolova, T., Zayulina, K., Bräsen, C., Bonch-Osmolovskaya, E. A., Peng, Xu, Kublanov, I. V. & Siebers, B., 2016, In: Frontiers in Microbiology. 7, 17 p., 552.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles
Mathelier, A., Fornes, O., Arenillas, D. J., Chen, C., Denay, G., Lee, J., Shi, W., Shyr, C., Tan, G., Worsley-Hunt, R., Zhang, A. W., Parcy, F., Lenhard, B., Sandelin, Albin Gustav & Wasserman, W. W., 2016, In: Nucleic Acids Research. 44, D1, p. D110-D115 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ladder variational autoencoders
Sønderby, C. K., Raiko, T., Maaløe, L., Sønderby, S. K. & Winther, Ole, 2016, Advances in Neural Information Processing Systems 29 (NIPS 2016). Lee, D. D., Sugiyama, M., Luxburg, U. V., Guyon, I. & Garnett, R. (eds.). Curran Associates, Inc., p. 3745-3753 9 p. (Advances in Neural Information Processing Systems, Vol. 29).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
Next-generation biology: sequencing and data analysis approaches for non-model organisms
Rodrigues da Fonseca, Rute Andreia, Albrechtsen, Anders, Themudo, G. E. C., Ramos Madrigal, Jazmin, Sibbesen, Jonas Andreas, Sørensen, L. M., Zepeda Mendoza, M. L., Campos, P., Heller, Rasmus & Pereira, R., 2016, In: Marine Genomics. 30, p. 3-13Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel viral genomes identified from six metagenomes reveal wide distribution of archaeal viruses and high viral diversity in terrestrial hot springs
Islin, S. R., Menzel, P., Krogh, Anders, Young, M. & Peng, Xu, 2016, In: Environmental Microbiology. 18, 3, p. 863-874 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nye artsbestemmelser af skind fra jernalderen– forhistoriske proteiner fra skindkapper fundet i danske moser
Brandt, Luise Ørsted, Cappellini, Enrico, Mannering, U. & Schmidt, A., 2016, In: Nationalmuseets Arbejdsmark. p. 234-247Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On-the-fly selection of cell-specific enhancers, genes, miRNAs and proteins across the human body using SlideBase
Ienasescu, H., Li, K., Andersson, Robin, Vitezic, M., Rennie, Sarah, Chen, Y., Vitting-Seerup, K., Lagoni, E., Boyd, M., Lange, Jette Bornholdt, de Hoon, M. J. L., Kawaji, H., Lassmann, T., FANTOM Consortium, F. C., Hayashizaki, Y., Forrest, A. R. R., Carninci, P. & Sandelin, Albin Gustav, 2016, In: Database: The Journal of Biological Databases and Curation. 2016, 0, 10 p., baw144.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oncogenic p95HER2 regulates Na+-HCO3- cotransporter NBCn1 mRNA stability in breast cancer cells via 3'UTR-dependent processes
Gorbatenko, A., Olesen, C. W., Loebl, N., Sigurdsson, H. H., Bianchi, C., Pedraz Cuesta, E., Christiansen, Jan & Pedersen, Stine Helene Falsig, 2016, In: Biochemical Journal. 473, 21, p. 4027-4044 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality
Pundhir, Sachin, Bagger, F. O., Lauridsen, F. K. B., Rapin, N. P. J. & Porse, Bo Torben, 2016, In: Nucleic Acids Research. 44, 9, p. 4037-4051 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacology and optimization of thiopurines and methotrexate in inflammatory bowel disease
Coskun, M., Steenholdt, Casper, de Boer, N. K. & Nielsen, Ole Haagen, 2016, In: Clinical Pharmacokinetics. 55, 3, p. 257-274 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postglacial viability and colonization in North America’s ice-free corridor
Pedersen, Mikkel Winther, Ruter, Anthony Henry, Schweger, C., Friebe, H., Staff, R. A., Kjeldsen, Kristian Kjellerup, Zepeda Mendoza, M. L., Beaudoin, A. B., Zutter, C., Larsen, Nicolaj Krog, Potter, B. A., Nielsen, Rasmus, Rainville, R. A., Orlando, L. A. A., Meltzer, D. J., Kjær, Kurt H. & Willerslev, Eske, 2016, In: Nature. 537, 7618, p. 45–49 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters
Chen, Y., Pai, A. A., Herudek, J., Lubas, M., Meola, N., Järvelin, A. I., Andersson, Robin, Pelechano, V., Steinmetz, L. M., Jensen, T. H. & Sandelin, Albin Gustav, 2016, In: Nature Genetics. 48, 9, p. 984-994 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probabilistic Methods for Processing High-Throughput Sequencing Signals
Sørensen, L. M., 2016, Department of Biology, Faculty of Science, University of Copenhagen. 173 p.Research output: Book/Report › Ph.D. thesis › Research
- Published
Probabilistic Transcriptome Assembly and Variant Graph Genotyping
Sibbesen, Jonas Andreas, 2016, Department of Biology, Faculty of Science, University of Copenhagen. 119 p.Research output: Book/Report › Ph.D. thesis › Research
- Published
RNA assemblages orchestrate complex cellular processes
Nielsen, Finn Cilius, Hansen, H. T. & Christiansen, Jan, 2016, In: BioEssays. 38, 7, p. 674-681 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RNA sequencing of trigeminal ganglia in Rattus Norvegicus after glyceryl trinitrate infusion with relevance to migraine
Pedersen, S. H., Sørensen, L. M., Ramachandran, R., Sibbesen, Jonas Andreas, Yakimov, V., Christensen, R. E., Hansen, Thomas Folkmann, Krogh, Anders, Olesen, Jes & Olesen, I. J., 2016, In: P L o S One. 11, 5, 13 p., e0155039.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulating retrotransposon activity through the use of alternative transcription start sites
Persson, J., Steglich, B., Smialowska, A., Boyd, M., Lange, Jette Bornholdt, Andersson, Robin, Schurra, C., Arcangioli, B., Sandelin, Albin Gustav, Nielsen, Olaf & Ekwall, K., 2016, In: E M B O Reports. 17, 5, p. 753-768 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequential neural models with stochastic layers
Fraccaro, M., Sønderby, S. K., Paquet, U. & Winther, Ole, 2016, Neural Information Processing Systems 2016. Lee, D. D., Sugiyama, M., Luxburg, U. V., Guyon, I. & Garnett, R. (eds.). Neural Information Processing Systems Foundation, p. 2207-2215 9 p. (Advances in Neural Information Processing Systems, Vol. 29).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
Testing parametric models in linear-directional regression
Garcia Portugues, E., van Keilegom, I., Crujeiras, R. M. & González-Manteiga, W., 2016, In: Scandinavian Journal of Statistics. 43, 4, p. 1178-1191 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The adipose transcriptional response to insulin is determined by obesity, not insulin sensitivity
Rydén, M., Hrydziuszko, O., Mileti, E., Raman, A., Lange, Jette Bornholdt, Boyd, M., Toft, E., Qvist, V., Näslund, E., Thorell, A., Andersson, D. P., Dahlman, I., Gao, H., Sandelin, Albin Gustav, Daub, C. O. & Arner, P., 2016, In: Cell Reports. 16, 9, p. 2317-2326 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The middle ear immune defense changes with age
Nielsen, M. C., Friis, M., Martin-Bertelsen, T., Winther, Ole, Friis-Hansen, Lennart Jan & Cayé-Thomasen, Per, 2016, In: European Archives of Oto-Rhino-Laryngology. 273, 1, p. 81-86 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The slicer activity of ARGONAUTE1 is required specifically for the phasing, not production, of trans-acting short interfering RNAs in Arabidopsis
Arribas Hernandez, Laura, Marchais, A., Poulsen, C., Haase, B., Hauptmann, J., Benes, V., Meister, G. & Brodersen, Peter, 2016, In: The Plant Cell. 28, 7, p. 1563-1580 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tools and data services registry: a community effort to document bioinformatics resources
Ison, J., Rapacki, K., Ménager, H., Kalaš, M., Rydza, E., Chmura, P., Anthon, C., Beard, N., Berka, K., Bolser, D., Booth, T., Bretaudeau, A., Brezovsky, J., Casadio, R., Cesareni, G., Coppens, F., Cornell, M., Cuccuru, G., Davidsen, K., Vedova, G. D. & 49 others, , 2016, In: Nucleic Acids Research. 44, D1, p. D38-D47 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional diversity and regulation across time and states
Vitting-Seerup, K., 2016, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
Transcriptome analysis of recurrently deregulated genes across multiple cancers identifies new pan-cancer biomarkers
Kaczkowski, B., Tanaka, Y., Kawaji, H., Sandelin, Albin Gustav, Andersson, Robin, Itoh, M., Lassmann, T., the FANTOM5 consortium, Hayashizaki, Y., Carninci, P. & Forrest, A. R. R., 2016, In: Cancer Research. 76, 2, p. 216-226Research output: Contribution to journal › Journal article › Research › peer-review
- Published
UPF2-dependent nonsense-mediated mRNA decay pathway is essential for spermatogenesis by selectively eliminating longer 3'UTR transcripts
Bao, J., Vitting-Seerup, K., Waage, J. E., Tang, C., Ge, Y., Porse, Bo Torben & Yan, W., 2016, In: P L o S Genetics. 12, 5, 24 p., e1005863.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unrecognized circulation of SAT 1 foot-and-mouth disease virus in cattle herds around Queen Elizabeth National Park in Uganda
Dhikusooka, M. T., Ayebazibwe, C., Namatovu, A., Belsham, G. J., Siegismund, Hans Redlef, Wekesa, S. N., Balinda, S. N., Muwanika, V. B. & Tjørnehøj, K., 2016, In: BMC Veterinary Research. 12, 13 p., 5.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Weighting sequence variants based on their annotation increases power of whole-genome association studies
Sveinbjornsson, G., Albrechtsen, Anders, Zink, F., Gudjonsson, S. A., Oddson, A., Másson, G., Holm, H., Kong, A., Thorsteinsdottir, U., Sulem, P., Gudbjartsson, D. F. & Stefansson, K., 2016, In: Nature Genetics. 48, 3, p. 314-317 4 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
mRNA decay of most arabidopsis miRNA targets requires slicer activity of AGO1
Arribas Hernandez, Laura, Kielpinski, L. J. & Brodersen, Peter, 2016, In: Plant Physiology. 171, 4, p. 2620-2632 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer
Pan, Y., Robertson, G., Pedersen, L., Lim, E., Hernandez-Herrera, A., Rowat, A. C., Patil, S. L., Chan, C. K., Wen, Y., Zhang, X., Basu-Roy, U., Mansukhani, A., Chu, A., Sipahimalani, P., Bowlby, R., Brooks, D., Thiessen, N., Coarfa, C., Ma, Y., Moore, R. A. & 8 others, , 2016, In: OncoTarget. 7, 18, p. 25930-25948 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A unified architecture of transcriptional regulatory elements
Andersson, Robin, Sandelin, Albin Gustav & Danko, C. G., Aug 2015, In: Trends in Genetics. 31, 8, p. 426-433 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Four Different Regulatory Mechanisms on the Dynamics of Gene Regulatory Cascades
Hansen, S., Krishna, S., Semsey, S. & Svenningsen, Sine Lo, 17 Jul 2015, In: Scientific Reports. 5, 12186.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CENTRAL LIMIT THEOREMS FOR DIRECTIONAL AND LINEAR RANDOM VARIABLES WITH APPLICATIONS
Garcia-Portugues, E., Crujeiras, R. M. & Gonzalez-Manteiga, W., Jul 2015, In: Statistica Sinica. 25, 3, p. 1207-1229Research output: Contribution to journal › Journal article › Research › peer-review
- Published
YeastFab: The design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae
Guo, Y., Dong, J., Zhou, T., Auxillos, Jamie Yam, Li, T., Zhang, W., Wang, L., Shen, Y., Luo, Y., Zheng, Y., Lin, J., Chen, G. Q., Wu, Q., Cai, Y. & Dai, J., 27 Apr 2015, In: Nucleic Acids Research. 43, 13, p. e88Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular origin of prognostic chromosomal aberrations in AML patients
Mora-Jensen, H., Jendholm, L. J., Rapin, N. P. J., Andersen, M. K., Roug, A. S., Bagger, F. O., Bullinger, L., Winther, Ole, Borregaard, N., Porse, Bo Torben & Theilgaard-Mønch, Kim, 11 Feb 2015, In: Leukemia. 29, p. 1785-1789 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation
Seidelin, Jakob Benedict, Larsen, S., Linnemann, D., Vainer, B., Coskun, M., Troelsen, J. T. & Nielsen, Ole Haagen, Jan 2015, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 308, 2, p. G92-G99 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
De novo assembly of a haplotype-resolved human genome
Cao, H., Wu, H., Luo, R., Huang, S., Sun, Y., Tong, X., Xie, Y., Liu, B., Yang, H., Zheng, H., Li, J., Li, B., Wang, Y., Yang, F., Sun, P., Liu, S., Gao, P., Huang, H., Sun, J., Chen, D. & 21 others, , 2015, In: Nature Biotechnology. 33, 6, p. 617-626 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drosophila Imp iCLIP identifies an RNA assemblage coordinating F-actin formation
Hansen, H. T., Rasmussen, S. H., Adolph, S. K., Plass, M., Krogh, Anders, Sanford, J., Nielsen, Finn Cilius & Christiansen, Jan, 2015, In: Genome Biology (Online Edition). 16, 16 p., 123.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A computational method for identification of vaccine targets from protein regions of conserved human leukocyte antigen binding
Olsen, L. R., Simon, C., Kudahl, U. J., Bagger, F. O., Winther, Ole, Reinherz, E. L., Zhang, G. L. & Brusic, V., 2015, In: B M C Medical Genomics. 8, Suppl 4, 6 p., 5.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis
Ribeiro, Â. M., Zepeda Mendoza, M. L., Bertelsen, Mads Frost, Kristensen, Annemarie T., Jarvis, E. D., Gilbert, M Thomas P & Rodrigues da Fonseca, Rute Andreia, 2015, In: B M C Evolutionary Biology. 15, 8 p., 124.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes
Acevedo, N., Reinius, L. E., Vitezic, M., Fortino, V., Söderhäll, C., Honkanen, H., Veijola, R., Simell, O., Toppari, J., Ilonen, J., Knip, M., Scheynius, A., Hyöty, H., Greco, D. & Kere, J., 2015, In: Clinical Epigenetics. 7, 20 p., 34.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported
Håkansson, K., Bachert, C., Konge, Lars, Thomsen, Simon Francis, Pedersen, Anders Elm, Poulsen, Steen Seier, Martin-Bertelsen, T., Winther, Ole, Backer, Vibeke & von Buchwald, Christian, 2015, In: PloS one. 10, 7, 11 p., e0127228.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Alternative Promoter Usage in Healthy and Inflamed Tissue
Lilje, B., 2015, Department of Biology, Faculty of Science, University of Copenhagen.Research output: Book/Report › Ph.D. thesis › Research
- Published
Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq
Jakobsen, J. S., Bagger, F. O., Hasemann, M. S., Schuster, Mikkel Bruhn, Frank, Anne-Katrine, Waage, J., Vitting-Seerup, K. & Porse, Bo Torben, 2015, In: BMC Genomics. 16, p. 46Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An updated evolutionary classification of CRISPR-Cas systems
Makarova, K. S., Wolf, Y. I., Alkhnbashi, O. S., Costa, F., Shah, S. A., Saunders, S. J., Barrangou, R., Brouns, S. J. J., Charpentier, E., Haft, D. H., Horvath, P., Moineau, S., Mojica, F. J. M., Terns, R. M., Terns, M. P., White, M. F., Yakunin, A. F., Garrett, R. A., van der Oost, J., Backofen, R. & 1 others, , 2015, In: Nature Reviews. Microbiology. 13, 11, p. 722-736 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reconstructing genome evolution in historic samples of the Irish potato famine pathogen
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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True single-molecule DNA sequencing of a pleistocene horse bone
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