Computational and RNA Biology

  1. Published

    The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2022 update

    Afgan, E., Nekrutenko, A., Grüning, B. A., Blankenberg, D., Goecks, J., Schatz, M. C., Ostrovsky, A. E., Mahmoud, A., Lonie, A. J., Syme, A., Fouilloux, A., Bretaudeau, A., Nekrutenko, A., Kumar, A., Eschenlauer, A. C., Desanto, A. D., Guerler, A., Serrano-Solano, B., Batut, B., Grüning, B. A. & 85 others, Langhorst, B. W., Carr, B., Raubenolt, B. A., Hyde, C. J., Bromhead, C. J., Barnett, C. B., Royaux, C., Gallardo, C., Blankenberg, D., Fornika, D. J., Baker, D., Bouvier, D., Clements, D., De Lima Morais, D. A., Tabernero, D. L., Lariviere, D., Nasr, E., Afgan, E., Zambelli, F., Heyl, F., Psomopoulos, F., Coppens, F., Price, G. R., Cuccuru, G., Corguillé, G. L., Von Kuster, G., Akbulut, G. G., Rasche, H., Hans-Rudolf, H., Eguinoa, I., Makunin, I., Ranawaka, I. J., Taylor, J. P., Joshi, J., Hillman-Jackson, J., Chilton, J. M., Kamali, K., Suderman, K., Poterlowicz, K., Yvan, L. B., Lopez-Delisle, L., Sargent, L., Bassetti, M. E., Tangaro, M. A., Van Den Beek, M., Cech, M., Bernt, M., Fahrner, M., Tekman, M., Föll, M. C., Schatz, M. C., Crusoe, M. R., Roncoroni, M., Kucher, N., Coraor, N., Stoler, N., Rhodes, N., Soranzo, N., Pinter, N., Goonasekera, N. A., Moreno, P. A., Videm, P., Melanie, P., Mandreoli, P., Jagtap, P. D., Gu, Q., Weber, R. J. M., Lazarus, R., Vorderman, R. H. P., Hiltemann, S., Golitsynskiy, S., Garg, S., Bray, S. A., Gladman, S. L., Leo, S., Mehta, S. P., Griffin, T. J., Jalili, V., Yves, V., Wen, V., Nagampalli, V. K., Bacon, W. A., De Koning, W., Maier, W. & Briggs, P. J., 2022, In: Nucleic Acids Research. 50, W1, p. W345-W351 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

    Sparsø, T., Andersen, G., Nielsen, T., Burgdorf, K. S., Gjesing, A. M. P., Nielsen, A. L., Albrechtsen, Anders, Rasmussen, S. S., Jørgensen, T., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Madsbad, Sten, Hansen, Torben & Pedersen, Oluf Borbye, 2007, In: Diabetologia. 51, 1, p. 70-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The GBAF chromatin remodeling complex binds H3K27ac and mediates enhancer transcription

    Jefimov, K., Alcaraz, N., Kloet, S. L., Värv, S., Sakya, S. A., Vaagenso, C., Vermeulen, M., Aasland, R. & Andersson, Robin, 2018, 31 p.

    Research output: Working paperPreprint

  4. Published

    The Draft Genome of Red Lechwe, Kobus leche leche

    Wang, B., Wang, Z., Zhou, J., Liu, W., Lin, Z., Zhang, C., Liu, G., Zhou, B., Wan, W., Zhao, R., Wang, W., Heller, Rasmus & Chen, L., 2020, In: Frontiers in Genetics. 11, 7 p., 582638.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The Block Hidden Markov Model for Biological Sequence Analysis

    Won, K. J., Prügel-Bennett, A. & Krogh, Anders, 2004, Knowledge-BasedIntelligent Informationand Engineering Systems: 8th International Conference, KES 2004, Proceedings. Negoita, M. G., Howlett, R. J. & Jain, L. (eds.). Springer, Vol. 1. p. 64-70 7 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Vol. 3213).

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  6. Published

    The Bipolar Illness Onset study: research protocol for the BIO cohort study

    Kessing, Lars Vedel, Munkholm, K., Faurholt-Jepsen, M., Miskowiak, Kamilla, Nielsen, L. B., Frikke-Schmidt, Ruth, Ekstrøm, Claus Thorn, Winther, Ole, Pedersen, Bente Klarlund, Poulsen, Henrik Enghusen, McIntyre, R. S., Kapczinski, F., Gattaz, W. F., Bardram, J., Frost, M., Mayora, O., Knudsen, Gitte Moos, Phillips, M. & Vinberg, Maj, 2017, In: BMJ Open. 7, 6, 12 p., e015462.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The AIMe registry for artificial intelligence in biomedical research

    Matschinske, J., Alcaraz, N., Benis, A., Golebiewski, M., Grimm, D. G., Heumos, L., Kacprowski, T., Lazareva, O., List, M., Louadi, Z., Pauling, J. K., Pfeifer, N., Röttger, R., Schwämmle, V., Sturm, G., Traverso, A., Van Steen, K., de Freitas, M. V., Villalba Silva, G. C., Wee, L. & 5 others, Wenke, N. K., Zanin, M., Zolotareva, O., Baumbach, J. & Blumenthal, D. B., 2021, In: Nature Methods. 18, 10, p. 1128-1131 4 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  8. Published

    The bchU gene of Chlorobium tepidum encodes the C-20 methyltransferase in bacteriochlorophyll c biosynthesis

    Maresca, J. A., Gomez Maqueo Chew, A., Ponsatí, M. R., Frigaard, Niels-Ulrik, Ormerod, J. G. & Bryant, D. A., 2004, In: Journal of Bacteriology. 186, 9, p. 2558-2566 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The 4.5 S RNA gene of Escherichia coli is essential for cell growth

    Brown, Stanley & Fournier, M. J., 1984, In: Journal of Molecular Biology. 178, 3, p. 533-50 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects

    Grarup, N., Andreasen, C. H., Lepola, Mette Andersen, Albrechtsen, Anders, Sandbaek, A., Lauritzen, T., Borch-Johnsen, K., Jørgensen, T., Schmitz, O., Hansen, T. & Pedersen, Oluf Borbye, 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, 6, p. 2294-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Testing parametric models in linear-directional regression

    Garcia Portugues, E., van Keilegom, I., Crujeiras, R. M. & González-Manteiga, W., 2016, In: Scandinavian Journal of Statistics. 43, 4, p. 1178-1191 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Testing for Hardy-Weinberg equilibrium in structured populations using genotype or low-depth next generation sequencing data

    Meisner, Jonas & Albrechtsen, Anders, 2019, In: Molecular Ecology Resources. 19, 5, p. 1144-1152 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans

    Moreno Mayar, J. Víctor, Potter, B. A., Vinner, Lasse, Steinrucken, M., Rasmussen, Simon, Terhorst, J., Kamm, J. A., Albrechtsen, Anders, Malaspinas, A., Sikora, Martin, Reuther, J. D., Irish, J. D., Malhi, R. S., Orlando, L. A. A., Song, Y. S., Nielsen, Rasmus, Meltzer, D. J. & Willerslev, Eske, 2018, In: Nature Genetics. 553, 7687, p. 203-207 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  14. Published

    Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries

    Jakobsen, J. S., Waage, J., Rapin, N., Bisgaard, Hanne Cathrine, Larsen, F. S. & Porse, Bo Torben, Apr 2013, In: Genome Research. 23, 4, p. 592-603 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

    Bruedigam, C., Bagger, F. O., Heidel, F. H., Kuhn, C. P., Guignes, S., Song, A., Austin, R., Vu, T., Lee, E., Riyat, S., Moore, A. S., Lock, R. B., Bullinger, L., Hill, G. R., Armstrong, S. A., Williams, D. A. & Lane, S. W., 2014, In: Cell Stem Cell. 15, 6, p. 775-790 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Technical Considerations for Transcatheter Aortic Valve Replacement With the Navitor Transcatheter Heart Valve

    Wong, I., Bajoras, V., Wang, X., Bieliauskas, G., De Backer, Ole & Søndergaard, Lars, 2021, In: JACC: Cardiovascular Interventions. 14, 19, p. e259-e261

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Teaching computers to fold proteins

    Winther, O. & Krogh, Anders, 2004, In: Physical Review E (Statistical, Nonlinear, and Soft Matter Physics). Vol. 70 (3) pt. 1, p. 030903

    Research output: Contribution to journalJournal articleResearch

  18. Published

    Targets of balancing selection in the human genome

    Andrés, A. M., Hubisz, M. J., Indap, A., Torgerson, D. G., Degenhardt, J. D., Boyko, A. R., Gutenkunst, R. N., White, T. J., Green, E. D., Bustamante, C. D., Clark, A. G. & Nielsen, Rasmus, 2009, In: Molecular Biology and Evolution. 26, 12, p. 2755-64 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Targeted next-generation sequencing analysis identifies novel mutations in families with severe familial exudative vitreoretinopathy

    Huang, X., Zhuang, H., Wu, J., Li, J., Hu, F., Zheng, Y., Tellier, L. C. A. M., Zhang, S., Gao, F., Zhang, J. & Xu, G., 23 Aug 2017, In: Molecular Vision. 23, p. 605-613 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Targeted conservation genetics of the endangered chimpanzee

    Frandsen, P., Fontsere, C., Nielsen, S. V., Hanghøj, Kristian Ebbesen, Castejon-Fernandez, N., Lizano, E., Hughes, D., Hernandez-Rodriguez, J., Korneliussen, Thorfinn Sand, Carlsen, F., Siegismund, Hans Redlef, Mailund, T., Marques-Bonet, T. & Hvilsom, C., 2020, In: Heredity. 125, 1-2, p. 15-27 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Tanimoto's Best Barbecue: Discovering Regulatory Modules using Tanimoto Scores

    Menzel, K. P., Mosig, A. & Stadler, P. F., 2007, Lecture Notes in Informatics: Proceedings of the German Conference on Bioinformatics 2007. Falter, C., Schliep, A., Selbig, J. & Walther, M. V. A. (eds.). p. 68-77 10 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  22. Published

    TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

    Willer, A., Jakobsen, J. S., Ohlsson, E., Rapin, N., Waage, J., Billing, M., Bullinger, L., Karlsson, S. & Porse, Bo Torben, 2015, In: Leukemia. 29, p. 1018-31 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes

    Distefano, R., Ilieva, M., Madsen, J. H., Ishii, H., Aikawa, M., Rennie, Sarah & Uchida, S., 2023, In: Non-coding RNA. 9, 3, 20 p., 30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Systematic review of machine learning for diagnosis and prognosis in dermatology

    Thomsen, K., Iversen, L., Titlestad, T. L. & Winther, Ole, 2020, In: Journal of Dermatological Treatment. 31, 5, p. 496-510

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis

    Pauli, A., Valen, E., Lin, M. F., Garber, M., Vastenhouw, N. L., Levin, J. Z., Fan, L., Sandelin, Albin Gustav, Rinn, J. L., Regev, A. & Schier, A. F., 2012, In: Genome Research. 22, p. 577-591 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Systematic clustering of transcription start site landscapes

    Zhao, X., Valen, E., Parker, B. J. & Sandelin, Albin Gustav, 2011, In: P L o S One. 6, 8, 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Systematic Analysis of Long Non-Coding RNAs in Inflammasome Activation in Monocytes/Macrophages

    Qian, N., Distefano, R., Ilieva, M., Madsen, J. H., Rennie, Sarah & Uchida, S., 2023, In: Non-coding RNA. 9, 5, 16 p., 50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity

    Wenger, Alice, Biran, Alva Ada, Alcaraz, N., Redó-Riveiro, A., Sell, Annika Charlotte, Krautz, Robert, Flury, Valentin, Reveron-Gomez, Nazaret, Solis-Mezarino, V., Völker-Albert, M., Imhof, A., Andersson, Robin, Brickman, Joshua Mark & Groth, Anja, 2023, In: Nature Genetics. 55, 9, p. 1567-1578 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Surface exposed amino acid differences between mesophilic and thermophilic phosphoribosyl diphosphate synthase.

    Hove-Jensen, B. & McGuire, J. N., 2004, In: European Journal of Biochemistry. 271, 22, p. 4526-33 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Sulfur metabolism in phototrophic sulfur bacteria

    Frigaard, Niels-Ulrik & Dahl, C., 2008, In: Advances in Microbial Physiology. 54, p. 103-200 97 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Sugar metabolism of the first thermophilic Planctomycete Thermogutta terrifontis: comparative genomic and transcriptomic approaches

    Elcheninov, A. G., Menzel, P., Gudbergsdottir, S. R., Slesarev, A. I., Kadnikov, V. V., Krogh, Anders, Bonch-Osmolovskaya, E. A., Peng, Xu & Kublanov, I. V., 2 Nov 2017, In: Frontiers in Microbiology. 8, 11 p., 2140.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Subtle Monte Carlo updates in dense molecular systems

    Bottaro, S., Boomsma, Wouter, Johansson, Kristoffer Enøe, Andreetta, C., Hamelryck, Thomas Wim & Ferkinghoff-Borg, J., 2012, In: Journal of Chemical Theory and Computation. 8, 2, p. 695-702 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Subcellular localization of chlorosome proteins in Chlorobium tepidum and characterization of three new chlorosome proteins: CsmF, CsmH, and CsmX

    Vassilieva, E. V., Stirewalt, V. L., Jakobs, C. U., Frigaard, Niels-Ulrik, Inoue-Sakamoto, K., Baker, M. A., Sotak, A. & Bryant, D. A., 2002, In: Biochemistry. 41, p. 4358-4370 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Studies of the location and function of isoprenoid quinones in chlorosomes from green sulfur bacteria

    Frigaard, Niels-Ulrik, Matsuura, K., Hirota, M., Miller, M. & Cox, R. P., 1998, In: Photosynthesis Research. 58, p. 81-90 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

    Grarup, Niels, Lepola, Mette Andersen, Andreasen, C. H., Albrechtsen, Anders, Borch-Johnsen, K., Jørgensen, T., Auwerx, J., Schmitz, O., Hansen, Torben & Pedersen, Oluf Borbye, 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 1, p. 363-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes

    Johansson, E., Fanø, M., Bynck, J. H., Neuhard, J., Larsen, S., Sigurskjold, B. W., Christensen, U. & Willemoës, Martin, 2005, In: Journal of Biological Chemistry. 280, 4, p. 3051-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Structures and Interactions of Proteins in the Brain: The Interaction Between LRP1 and Aß & Structure and Self-Assembly of Arc

    Nielsen, L. D., 2017, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/ReportPh.D. thesisResearch

  38. Published

    Structure of PhnP: a phosphodiesterase of the carbon-phosphorous lyase pathway for phosphonate degradation

    Podzelinska, K., He, S., Wathier, M., Yakunin, A., Proudfoot, M., Hove-Jensen, B., Zechel, D. L. & Jia, Z., 2009, In: Journal of Biological Chemistry. 284, 25, p. 17216-17226

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Structure of Dihydroorotate Dehydrogenase B: Electron Transfer between Two Flavin Groups Bridged by an Iron-Sulphur Cluster

    Rowland, P., Nørager, S., Jensen, K. F. & Larsen, Sine, 2000, In: Structure. 8, 12, p. 1227-1238

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Structural, kinetic, and mutational studies of the zinc ion environment in tetrameric cytidine deaminase

    Johansson, E., Neuhard, J., Willemoës, Martin & Larsen, Sine, 2004, In: Biochemistry. 43, 20, p. 6020-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Structural profiles of human miRNA families from pairwise clustering

    Kaczkowski, B., Þórarinsson, E., Reiche, K., Havgaard, Jakob Hull, Stadler, P. F. & Gorodkin, Jan, 2009, In: Bioinformatics. 25, 3, p. 291-294 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Structural and kinetic studies of the allosteric transition in Sulfolobus solfataricus uracil phosphoribosyltransferase: Permanent activation by engineering of the C-terminus

    Christoffersen, S., Kadziola, Anders, Johansson, E., Rasmussen, M., Willemoës, Martin & Jensen, K. F., 2009, In: Journal of Molecular Biology. 393, 2, p. 464-477

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Structural and enzymatic investigation of the Sulfolobus solfataricus uridylate kinase shows competitive UTP inhibition and the lack of GTP stimulation.

    Jensen, K. S., Johansson, E. & Jensen, K. F., 2007, In: Biochemistry. 46, 10, p. 2745-57 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Steady State Kinetic Model for the Binding of Substrates and Allosteric Effectors to Escherichia coli Phosphoribosyl-diphosphate Synthase.

    Willemoës, Martin, Hove-Jensen, B. & Larsen, Sine, 2000, In: Journal of Biological Chemistry. 45, p. 35408-35412

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Statistics of bivariate von mises distributions

    Mardia, K. V. & Frellsen, J., 2012, Bayesian methods in structural bioinformatics. Hamelryck, T., Mardia, K. & Ferkinghoff-Borg, J. (eds.). Springer, p. 159-178 20 p. (Statistics for Biology and Health).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  46. Published

    Statistical inferences in phylogeography

    Nielsen, Rasmus & Beaumont, M. A., 2009, In: Molecular Ecology. 18, 6, p. 1034-47 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published
  48. Published

    Statistical assignment of DNA sequences using Bayesian phylogenetics

    Terkelsen, K. M., Boomsma, Wouter, Huelsenbeck, J. P., Willerslev, Eske & Nielsen, Rasmus, 2008, In: Systematic Biology. 57, 5, p. 750-757 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Statistical Approaches Accomodating Uncertainty in Modern Genomic Data

    Skotte, L., 2015, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/ReportPh.D. thesisResearch

  50. Published

    Sphingosine-1-phosphate signaling in inflammatory bowel disease

    Nielsen, Ole Haagen, Li, Yuan, Lindbom, B. J. & Coskun, M., Apr 2017, In: Trends in Molecular Medicine. 23, 4, p. 362-374 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

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