- 2021
- Published
Detecting selection in low-coverage high-throughput sequencing data using principal component analysis
Meisner, Jonas, Albrechtsen, Anders & Hanghøj, Kristian Ebbesen, 2021, In: BMC Bioinformatics. 22, 13 p., 470.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J. A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M. C., Abugessaisa, I., Aitken, S. & 31 others, , 2021, In: Nature Communications. 12, 18 p., 3297.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry
Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient Generative Modelling of Protein Structure Fragments using a Deep Markov Model
Thygesen, Christian Bahne, Al-Sibahi, A. S., Steenmanns, C. S., Sanz Moreta, Lys, Sørensen, A. B. & Hamelryck, Thomas Wim, 2021, International Conference on Machine Learning, 18-24 July 2021, Virtual. PMLR, p. 10258-10267 (Proceedings of Machine Learning Research, Vol. 139).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
Emergence and radiation of distemper viruses in terrestrial and marine mammals
Stokholm, Iben, Puryear, W., Sawatzki, K., Knudsen, Steen Wilhelm, Terkelsen, Thilde Bagger, Becher, P., Siebert, U. & Olsen, Morten Tange, 2021, In: Proceedings of the Royal Society B: Biological Sciences. 288, 1961, 9 p., 20211969.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning
Xiang, X., Corsi, G. I., Anthon, C., Qu, K., Pan, X., Liang, X., Han, P., Dong, Z., Liu, L., Zhong, J., Ma, T., Wang, J., Zhang, X., Jiang, H., Xu, F., Liu, X., Xu, X., Wang, J., Yang, H., Bolund, L. & 4 others, , 2021, In: Nature Communications. 12, 1, 9 p., 3238.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolutionary history of the roan antelope across its African range
Gonçalves, M., Siegismund, Hans Redlef, van Vuuren, B. J., Ferrand, N. & Godinho, R., 2021, In: Journal of Biogeography. 48, 11, p. 2812-2827 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide and sister chromatid-resolved profiling of protein occupancy in replicated chromatin with ChOR-seq and SCAR-seq
Petryk, N., Reveron-Gomez, Nazaret, González-Aguilera, C., Dalby, M., Andersson, Robin & Groth, Anja, 2021, In: Nature Protocols. 16, p. 4446-4493Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic Stability and Phenotypic Characteristics of Industrially Produced Lacticaseibacillus rhamnosus GG in a Yogurt Matrix
Strickertsson, Marianne Stage, Hui, Y., Nielsen, Dennis Sandris, Vera-Jimenéz, N. I., Olsen, J., Sandelin, Albin Gustav & Wichmann, A., 2021, In: Applied and Environmental Microbiology. 87, 24, 18 p., e01575-21.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic insights into the conservation status of the world's last remaining Sumatran rhinoceros populations
von Seth, J., Dussex, N., Diez-del-Molino, D., van der Valk, T., Kutschera, V. E., Kierczak, M., Steiner, C. C., Liu, S., Gilbert, M. T. P., Sinding, M-H. S., Prost, S., Guschanski, K., Nathan, S. K. S. S., Brace, S., Chan, Y. L., Wheat, C. W., Skoglund, P., Ryder, O. A., Goossens, B., Gotherstrom, A. & 1 others, , 2021, In: Nature Communications. 12, 1, 11 p., 2393.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., Adamopoulos, I. E., Adeli, K., Adolph, T. E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B. B., Agnello, M., Agostinis, P. & 2,908 others, , 2021, In: Autophagy. 17, p. 1-382 382 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
High genetic diversity and low differentiation reflect the ecological versatility of the African leopard
Chrzanová Pecnerová, Patrícia, Garcia Erill, Genís, Liu, Xiaodong, Nursyifa, Casia, Waples, R. K., Santander, Cindy, Quinn, Liam James Elgaard, Frandsen, P., Meisner, Jonas, Stæger, Frederik Filip Vinggaard, Rasmussen, Malthe Sebro, Brüniche-Olsen, Anna, Jørgensen, C. H. F., Rodrigues da Fonseca, Rute Andreia, Siegismund, Hans Redlef, Albrechtsen, Anders, Heller, Rasmus, Moltke, Ida & Hanghøj, Kristian Ebbesen, 2021, In: Current Biology. 31, 9, p. 1862-1871, e1-e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype-specific serologically relevant biomarkers
Terkelsen, T., Pernemalm, M., Gromov, P., Borresen-Dale, A., Krogh, Anders, Haakensen, V. D., Lethio, J., Papaleo, E. & Gromova, I., 2021, In: Molecular Oncology. 15, 2, p. 429-461 33 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How robust are cross-population signatures of polygenic adaptation in humans?
Refoyo Martínez, Alba, Liu, S., Jørgensen, A. M., Jin, X., Albrechtsen, Anders, Martin, A. R. & Racimo, Fernando, 2021, In: Peer Community Journal. 1, 54 p., e22.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identifying a living great-grandson of the Lakota Sioux leader Tatanka Iyotake (Sitting Bull)
Moltke, Ida, Korneliussen, Thorfinn Sand, Seguin-Orlando, A., Moreno Mayar, J. Víctor, LaPointe, E., Billeck, W. & Willerslev, Eske, 2021, In: Science Advances. 7, 44, 7 p., eabh2013.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved metagenome binning and assembly using deep variational autoencoders
Nissen, J. N., Johansen, Joachim, Allesoe, R. L., Sonderby, C. K., Armenteros, J. J. A., Grønbech, Christopher Heje, Jensen, Lars Juhl, Nielsen, H. B., Petersen, T. N., Winther, Ole & Rasmussen, Simon, 2021, In: Nature Biotechnology. 39, p. 555-560Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigation of the Impact of the RNA Exosome on Cellular Transcriptome and Function
Wu, M., 2021, Department of Biology, Faculty of Science, University of Copenhagen. 154 p.Research output: Book/Report › Ph.D. thesis › Research
- Published
Large-scale inference of population structure in presence of missingness using PCA
Meisner, Jonas, Liu, S., Huang, M. & Albrechtsen, Anders, 2021, In: Bioinformatics. 37, 13, p. 1868-1875 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Life-history traits and habitat availability shape genomic diversity in birds: implications for conservation
Brüniche-Olsen, Anna, Kellner, K. F., Belant, J. L. & DeWoody, J. A., 2021, In: Proceedings of the Royal Society B: Biological Sciences. 288, 1961, 9 p., 21001441.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Light-Dependent Translation Change of Arabidopsis psbA Correlates with RNA Structure Alterations at the Translation Initiation Region
Gawroński, P., Enroth, Christel Hougård, Kindgren, P., Marquardt, Sebastian, Karpiński, S., Leister, D., Jensen, Poul Erik, Vinther, Jeppe & Scharff, L. B., 2021, In: Cells. 10, 2, 22 p., 322.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the degradation pathway of a disease-linked aspartoacylase variant
Gersing, S. K., Wang, Y., Grønbæk-Thygesen, Martin, Kampmeyer, Caroline, Bjørnkjær, Lene, Willemoës, Martin, Andréasson, C., Stein, Amelie, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 2021, In: PLOS Genetics. 17, 4, 28 p., e1009539.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping the human genetic architecture of COVID-19
Niemi, M. E. K., Karjalainen, J., Liao, R. G., Neale, B. M., Daly, M., Ganna, A., Pathak, G. A., Andrews, S. J., Kanai, M., Veerapen, K., Fernandez-Cadenas, I., Schulte, E. C., Striano, P., Marttila, M., Minica, C., Marouli, E., Karim, M. A., Wendt, F. R., Savage, J., Sloofman, L. & 41 others, , 2021, In: Nature. 600, p. 472-477Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Million-year-old DNA sheds light on the genomic history of mammoths
van der Valk, T., Pečnerová, P., Díez-del-Molino, D., Bergström, A., Oppenheimer, J., Hartmann, S., Xenikoudakis, G., Thomas, J. A., Dehasque, M., Sağlıcan, E., Fidan, F. R., Barnes, I., Liu, S., Somel, M., Heintzman, P. D., Nikolskiy, P., Shapiro, B., Skoglund, P., Hofreiter, M., Lister, A. M. & 2 others, , 2021, In: Nature. 591, 7849, p. 265-269Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modes of genetic adaptations underlying functional innovations in the rumen
Pan, X., Cai, Y., Li, Z., Chen, X., Heller, R., Wang, N., Wang, Y., Zhao, C., Wang, Y., Xu, H., Li, S., Li, M., Li, C., Hu, S., Li, H., Wang, K., Chen, L., Wei, B., Zheng, Z., Fu, W. & 20 others, , 2021, In: Science China Life Sciences. 64, 1, p. 1-21 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition
Nielsen, S. V., Hartmann-Petersen, Rasmus, Stein, Amelie & Lindorff-Larsen, Kresten, 2021, In: PLOS Genetics. 17, 4, 6 p., e1009496.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NGSremix: A software tool for estimating pairwise relatedness between admixed individuals from next-generation sequencing data
Nøhr, A. K., Hanghøj, Kristian Ebbesen, Garcia Erill, Genís, Li, Zilong, Moltke, Ida & Albrechtsen, Anders, 2021, In: G3: Genes, Genomes, Genetics. 11, 8, 8 p., jkab174.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data
Montemurro, A., Schuster, Viktoria, Povlsen, H. R., Bentzen, A. K., Jurtz, V., Chronister, W. D., Crinklaw, A., Hadrup, S. R., Winther, Ole, Peters, B., Jessen, L. E. & Nielsen, M., 2021, In: Communications Biology . 4, 13 p., 1060.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Opportunities and challenges of macrogenetic studies
Leigh, D. M., van Rees, C. B., Millette, K. L., Breed, M. F., Schmidt, C., Bertola, Laura, Hand, B. K., Hunter, M. E., Jensen, E. L., Kershaw, F., Liggins, L., Luikart, G., Manel, S., Mergeay, J., Miller, J. M., Segelbacher, G., Hoban, S. & Paz-Vinas, I., 2021, In: Nature Reviews Genetics. 22, 12, p. 791-807 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers
Schnurr, T. M., Jørsboe, E., Chadt, A., Dahl-Petersen, I. K., Kristensen, Jonas Møller, Wojtaszewski, Jørgen F P, Springer, C., Bjerregaard, P., Brage, S., Pedersen, Oluf Borbye, Moltke, Ida, Grarup, Niels, Al-Hasani, H., Albrechtsen, Anders, Jørgensen, M. E. & Hansen, Torben, 2021, In: Diabetologia. 64, p. 1795-1804Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pleistocene origins, western ghost lineages, and the emerging phylogeographic history of the red wolf and coyote
Sacks, B. N., Mitchell, K. J., Quinn, C. B., Hennelly, L. M., Sinding, Mikkel Holger Strander, Statham, M. J., Preckler-Quisquater, S., Fain, S. R., Kistler, L., Vanderzwan, S. L., Meachen, J. A., Ostrander, E. A. & Frantz, L. A. F., 2021, In: Molecular Ecology. 30, 17, p. 4292-4304 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictors and trajectories of treatment response to SSRIs in patients suffering from PTSD
Nøhr, A. K., Eriksson, H., Hobart, M., Moltke, Ida, Buller, R., Albrechtsen, Anders & Lindgreen, S., 2021, In: Psychiatry Research. 301, 8 p., 113964.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2
Arribas Hernandez, Laura, Rennie, Sarah, Köster, T., Porcelli, C., Lewinski, M., Staiger, D., Andersson, Robin & Brodersen, Peter, 2021, In: eLife. 10, 33 p., e72375.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reducing the rate of psychiatric re-admissions in bipolar disorder using smartphones - The RADMIS trial
Faurholt-Jepsen, M., Lindbjerg Tønning, M., Fros, M., Martiny, Klaus, Tuxen, N., Rosenberg, N., Busk, J., Winther, Ole, Thaysen-Petersen, D., Aamund, K. A., Tolderlund, L., Bardram, J. E. & Kessing, Lars Vedel, 2021, In: Acta Psychiatrica Scandinavica. 143, 5, p. 453-465 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Technical Considerations for Transcatheter Aortic Valve Replacement With the Navitor Transcatheter Heart Valve
Wong, I., Bajoras, V., Wang, X., Bieliauskas, G., De Backer, Ole & Søndergaard, Lars, 2021, In: JACC: Cardiovascular Interventions. 14, 19, p. e259-e261Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The AIMe registry for artificial intelligence in biomedical research
Matschinske, J., Alcaraz, N., Benis, A., Golebiewski, M., Grimm, D. G., Heumos, L., Kacprowski, T., Lazareva, O., List, M., Louadi, Z., Pauling, J. K., Pfeifer, N., Röttger, R., Schwämmle, V., Sturm, G., Traverso, A., Van Steen, K., de Freitas, M. V., Villalba Silva, G. C., Wee, L. & 5 others, , 2021, In: Nature Methods. 18, 10, p. 1128-1131 4 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
The LEAFY floral regulator displays pioneer transcription factor properties
Lai, X., Blanc-Mathieu, R., GrandVuillemin, L., Huang, Y., Stigliani, Arnaud, Lucas, J., Thévenon, E., Loue-Manifel, J., Turchi, L., Daher, H., Brun-Hernandez, E., Vachon, G., Latrasse, D., Benhamed, M., Dumas, R., Zubieta, C. & Parcy, F., 2021, In: Molecular Plant. 14, 5, p. 829-837 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Low-Expression Variant of FABP4 Is Associated With Cardiovascular Disease in Type 1 Diabetes
Dahlström, E. H., Saksi, J., Forsblom, C., Uglebjerg, N., Mars, N., Thorn, L. M., Harjutsalo, V., Rossing, Peter, Ahluwalia, Tarun Veer Singh, Lindsberg, P. J., Sandholm, N., Groop, P. H. & FinnDiane Study Group, F. S. G., 2021, In: Diabetes. 70, 10, p. 2391-2401 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation
Arribas Hernandez, Laura, Rennie, Sarah, Schon, M., Porcelli, C., Enugutti, B., Andersson, Robin, Nodine, M. D. & Brodersen, Peter, 2021, In: eLife. 10, 27 p., e72377.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of smartphone-based monitoring and treatment on the rate and duration of psychiatric readmission in patients with unipolar depressive disorder: The RADMIS randomized controlled trial
Tønning, M. L., Faurholt-Jepsen, Maria , Frost, M., Martiny, Klaus, Tuxen, N., Rosenberg, N., Busk, J., Winther, Ole, Melbye, S. A., Thaysen-Petersen, D., Aamund, K. A., Tolderlundh, L., Bardram, J. E. & Kessing, Lars Vedel, 2021, In: Journal of Affective Disorders. 282, p. 354-363 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The endangered White Sands pupfish (Cyprinodon tularosa) genome reveals low diversity and heterogenous patterns of differentiation
Black, A. N., Willoughby, J. R., Brüniche-Olsen, Anna, Pierce, B. L. & DeWoody, J. A., 2021, In: Molecular Ecology Resources. 21, 7, p. 2520-2532 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The genetic history of Greenlandic-European contact
Waples, R. K., Hauptmann, A. L., Seiding, I. H., Jørsboe, E., Jørgensen, M. E., Grarup, Niels, Andersen, M. K., Larsen, C. V. L., Bjerregaard, P., Hellenthal, G., Hansen, Torben, Albrechtsen, Anders & Moltke, Ida, 2021, In: Current Biology. 31, 10, p. 2214-2219.e4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The genetic impact of an Ebola outbreak on a wild gorilla population
Fontsere, C., Frandsen, P., Hernandez-Rodriguez, J., Niemann, Jonas, Scharff-Olsen, Camilla Hjorth, Vallet, D., Le Gouar, P., Ménard, N., Navarro, A., Siegismund, Hans Redlef, Hvilsom, C., Gilbert, M Thomas P, Kuhlwilm, M., Hughes, D. & Marques-Bonet, T., 2021, In: BMC Genomics. 22, 12 p., 735.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of a traditional and western diet on glucose homeostasis in Greenlandic Inuit carriers and non-carriers of type 2 diabetes variant in the TBC1D4 gene: A protocol for a randomized clinical trial
Møller, G., Lind, M. V., Hauptmann, A. L., Senftleber, N., Hansen, C. B., Hansen, Torben, Jørgensen, M. E. & Lauritzen, Lotte, 2021, In: Contemporary Clinical Trials Communications. 21, 6 p., 100734.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Three de novo variants in KMT2A (MLL) identified by whole exome sequencing in patients with Wiedemann–Steiner syndrome
Luo, S., Bi, B., Zhang, W., Zhou, R., Chen, W., Zhao, P., Huang, Y., Yuan, L. & He, X., 2021, In: Molecular Genetics & Genomic Medicine. 9, 10, 11 p., e1798.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time-efficient Bayesian Inference for a (Skewed) von Mises Distribution on the Torus in a Deep Probabilistic Programming Language
Rønning, Ola, Ley, C., Mardia, K. V. & Hamelryck, Thomas Wim, 2021, 2021 IEEE International Conference on Multisensor Fusion and Integration for Intelligent Systems (MFI). IEEE, p. 1-8Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
- Published
TrancriptomeReconstructoR: data-driven annotation of complex transcriptomes
Ivanov, M., Sandelin, Albin Gustav & Marquardt, Sebastian, 2021, In: BMC Bioinformatics. 22, 15 p., 290.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid
Flores-León, M., Alcaraz, N., Pérez-Domínguez, M., Torres-Arciga, K., Rebollar-Vega, R., De la Rosa-Velázquez, I. A., Arriaga-Canon, C., Herrera, L. A., Arias, C. & González-Barrios, R., 2021, In: Molecular Neurobiology. 58, 9, p. 4639-4651 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptome Analysis Identifies GATA3-AS1 as a Long Noncoding RNA Associated with Resistance to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients
Contreras-Espinosa, L., Alcaraz, N., De La Rosa-Velázquez, I. A., Díaz-Chávez, J., Cabrera-Galeana, P., Rebollar-Vega, R., Reynoso-Noverón, N., Maldonado-Martínez, H. A., González-Barrios, R., Montiel-Manríquez, R., Bautista-Sánchez, D., Castro-Hernández, C., Alvarez-Gomez, R. M., Jiménez-Trejo, F., Tapia-Rodríguez, M., García-Gordillo, J. A., Pérez-Rosas, A., Bargallo-Rocha, E., Arriaga-Canon, C. & Herrera, L. A., 2021, In: Journal of Molecular Diagnostics. 23, 10, p. 1306-1323 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unveiling mRNP composition by fluorescence correlation and cross-correlation spectroscopy using cell lysates
Mateu-Regué, À., Christiansen, Jan, Bagger, F. O., Hellriegel, C. & Nielsen, Finn Cilius, 2021, In: Nucleic Acids Research. 49, 20, 15 p., e119.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
VeTra: a tool for trajectory inference based on RNA velocity
Weng, Guangzheng, Kim, Junil & Won, K. J., 2021, In: Bioinformatics. 37, 20, p. 3509-3513 btab364.Research output: Contribution to journal › Journal article › Research › peer-review
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Reconstructing genome evolution in historic samples of the Irish potato famine pathogen
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Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome
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True single-molecule DNA sequencing of a pleistocene horse bone
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