Computational and RNA Biology

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  1. Published

    Cross-species ChIP-seq studies provide insights into regulatory strategies of PPAR¿ in adipocytes

    Schmidt, S. F., Jørgensen, M., Sandelin, Albin Gustav & Mandrup, S., 2012, In: Transcription. 3, 1, p. 19-24 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness

    Czaplinska, D., Ialchina, Renata, Andersen, Henriette Berg, Yao, Jiayi, Stigliani, Arnaud, Dannesboe, Johs, Flinck, M., Chen, X., Mitrega, J., Gnosa, S. P., Dmytriyeva, O., Alves, F., Napp, J., Sandelin, Albin Gustav & Pedersen, Stine Helene Falsig, 2023, In: International Journal of Cancer. 152, 6, p. 1210-1225 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Current and emerging approaches to define intestinal epithelium-specific transcriptional networks

    Olsen, A. K., Boyd, M., Danielsen, E. T. & Troelsen, J. T., Feb 2012, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 302, 3, p. G277-86

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Current challenges in understanding the role of enhancers in disease

    Zaugg, J. B., Sahlén, P., Andersson, Robin, Alberich-Jorda, M., de Laat, W., Deplancke, B., Ferrer, J., Mandrup, S., Natoli, G., Plewczynski, D., Rada-Iglesias, A. & Spicuglia, S., 2022, In: Nature Structural and Molecular Biology. 29, 12, p. 1148-1158 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Cytoplasmic mRNPs revisited: Singletons and condensates

    Mateu-Regue, A., Nielsen, Finn Cilius & Christiansen, Jan, 2020, In: BioEssays. 42, 12, 13 p., 2000097.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    DGCR8 HITS-CLIP reveals novel functions for the microprocessor

    Macias, S., Plass, M., Stajuda, A., Michlewski, G., Eyras, E. & Cáceres, J. F., 2012, In: Nature Structural and Molecular Biology. 19, 8

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    DGCR8 acts as an adaptor for the exosome complex to degrade double-stranded structured RNAs

    Macias, S., Cordiner, R. A., Gautier, P., Plass, M. & Caceres, J. F., 2015, In: Molecular Cell. 60, 6, p. 873-885 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    DNA metabarcoding illuminates the contribution of small and very small prey taxa to the diet of lions

    Groen, K., Beekenkamp, S., de Iongh, H. H., Lesilau, F., Chege, M., Narisha, L., Veldhuis, M., Bertola, Laura, van Bodegom, P. M. & Trimbos, K. B., 2023, In: Environmental DNA. 5, 6, p. 1321-1331 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    DNA supercoiling enhances cooperativity and efficiency of an epigenetic switch

    Norregaard, K., Andersson, M., Sneppen, Kim, Nielsen, Peter E., Brown, Stanley & Oddershede, L. B., 22 Oct 2013, In: Proceedings of the National Academy of Sciences USA (PNAS). 110, 43, p. 17386-91 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Daily estimates of clinical severity of symptoms in bipolar disorder from smartphone-based self-assessments

    Busk, J., Faurholt-Jepsen, M., Frost, M., Bardram, J. E., Kessing, Lars Vedel & Winther, Ole, 2020, In: Translational Psychiatry. 10, 12 p., 194.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    DamMet: ancient methylome mapping accounting for errors, true variants, and post-mortem DNA damage

    Hanghøj, Kristian Ebbesen, Renaud, Gabriel, Albrechtsen, Anders & Orlando, L., 2019, In: GigaScience. 8, 4, 6 p., giz025.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Darwinian and demographic forces affecting human protein coding genes.

    Nielsen, Rasmus, Hubisz, M. J., Hellmann, I., Torgerson, D., Andres, A. M., Albrechtsen, Anders, Gutenkunst, R., Adams, M. D., Cargill, M., Boyko, A., Indap, A., Bustamante, C. D. & Clark, A. G., 2009, In: Genome Research. 19, 5, p. 838-49 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    De Novo Assembly of 20 Chicken Genomes Reveals the Undetectable Phenomenon for Thousands of Core Genes on Microchromosomes and Subtelomeric Regions

    Li, M., Sun, C., Xu, N., Bian, P., Tian, X., Wang, X., Wang, Y., Jia, X., Heller, R., Wang, M., Wang, F., Dai, X., Luo, R., Guo, Y., Wang, X., Yang, P., Hu, D., Liu, Z., Fu, W., Zhang, S. & 10 others, Li, X., Wen, C., Lan, F., Siddiki, A. Z., Suwannapoom, C., Zhao, X., Nie, Q., Hu, X., Jiang, Y. & Yang, N., 2022, In: Molecular Biology and Evolution. 39, 4, 16 p., msac066.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    De Novo Pathway Enrichment with KeyPathwayMiner

    Alcaraz, N., Hartebrodt, A. & List, M., 2020, Protein-Protein Interaction Networks: Methods and Protocols. Canzar, S. & Ringeling, F. R. (eds.). Humana Press, p. 181-199 19 p. (Methods in Molecular Biology, Vol. 2074).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  15. Published

    De Novo Pathway-Based Classification of Breast Cancer Subtypes

    List, M., Alcaraz, N. & Batra, R., 2020, Protein-Protein Interaction Networks: Methods and Protocols. Canzar, S. & Ringeling, F. R. (eds.). Humana Press, p. 201-213 13 p. (Methods in Molecular Biology, Vol. 2074).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  16. Published

    Deciphering Transcriptional Regulation: Computational Approaches

    Valen, E., 2010, Museum Tusculanum. 97 p.

    Research output: Book/Report › Ph.D. thesis › Research

  17. Published

    Deciphering regulatory mechanisms underlying gene co-activity

    van Duin, Lucas, 2023, Department of Biology, Faculty of Science, University of Copenhagen. 131 p.

    Research output: Book/Report › Ph.D. thesis › Research

  18. Published

    Deconvolution of autoencoders to learn biological regulatory modules from single cell mRNA sequencing data

    Kinalis, S., Nielsen, Finn Cilius, Winther, Ole & Bagger, F. O., 2019, In: BMC Bioinformatics. 20, 9 p., 379.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Deep Learning for Diagnostic Binary Classification of Multiple-Lesion Skin Diseases

    Thomsen, K., Christensen, A. L., Iversen, L., Lomholt, H. B. & Winther, Ole, 2020, In: Frontiers in Medicine. 7, 7 p., 574329.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Deep Recurrent Conditional Random Field Network for Protein Secondary Prediction

    Johansen, A. R., Sønderby, C. K., Sønderby, S. K. & Winther, O., 2017, ACM-BCB '17: Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. p. 73-78 6 p.

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

  21. Published

    Deep integrative models for large-scale human genomics

    Sigurdsson, Arnór Ingi, Louloudis, Ioannis, Banasik, Karina, Westergaard, David, Winther, Ole, Lund, O., Ostrowski, Sisse Rye, Erikstrup, C., Pedersen, Ole Birger Vesterager, Nyegaard, Mette, Brunak, Søren, Vilhjálmsson, B. & Rasmussen, Simon, 2023, In: Nucleic Acids Symposium Series. 51, 12, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance

    Fort, A., Hashimoto, K., Yamada, D., Salimullah, M., Keya, C. A., Saxena, A., Bonetti, A., Voineagu, I., Bertin, N., Kratz, A., Noro, Y., Wong, C-H., de Hoon, M., Andersson, R., Sandelin, A. G., Suzuki, H., Wei, C-L., Koseki, H., Hasegawa, Y., Forrest, A. R. R. & 2 others, Carninci, P. & FANTOM Consortium, F. C., 2014, In: Nature Genetics. 46, 6, p. 558-566 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Deep-sequencing of viral genomes from a large and diverse cohort of treatment-naive HIV-infected persons shows associations between intrahost genetic diversity and viral load

    INSIGHT START Study Group, I. S. S. G., 2023, In: PLOS Computational Biology. 19, 1, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    DeepLoc: prediction of protein subcellular localization using deep learning

    Almagro Armenteros, J. J., Sønderby, C. K., Sønderby, S. K., Nielsen, H. & Winther, Ole, 1 Nov 2017, In: Bioinformatics. 33, 21, p. 3387-3395 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    DeepLoc 2.0: multi-label subcellular localization prediction using protein language models

    Thumuluri, V., Almagro Armenteros, J. J., Johansen, A. R., Nielsen, H. & Winther, Ole, 2022, In: Nucleic Acids Research. 50, W1, p. W228-W234

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    DeepLocRNA: an interpretable deep learning model for predicting RNA subcellular localization with domain-specific transfer-learning

    Wang, Jun, Horlacher, M., Cheng, L. & Winther, Ole, 2024, In: Bioinformatics. 40, 2, 10 p., btae065.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    DeepPeptide predicts cleaved peptides in proteins using conditional random fields

    Teufel, Felix Georg, Refsgaard, J. C., Madsen, C. T., Stahlhut, C., Grønborg, M., Winther, Ole & Madsen, D., 2023, In: Bioinformatics (Oxford, England). 39, 10, 6 p., btad616.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Demographic inferences from large-scale NGS data

    Pedersen, C. T., 2017, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  29. Published

    Deorphanizing Peptides Using Structure Prediction

    Teufel, Felix Georg, Refsgaard, J. C., Kasimova, M. A., Deibler, K., Madsen, C. T., Stahlhut, C., Grønborg, M., Winther, Ole & Madsen, D., 2023, In: Journal of Chemical Information and Modeling. 63, 9, 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    DermX: An end-to-end framework for explainable automated dermatological diagnosis

    Jalaboi, R., Faye, F., Orbes-Arteaga, M., Jørgensen, D., Winther, Ole & Galimzianova, A., 2023, In: Medical Image Analysis. 83, 12 p., 102647.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Design of association studies with pooled or un-pooled next-generation sequencing data

    Kim, S. Y., Li, Y., Guo, Y., Li, R., Holmkvist, J., Hansen, Torben, Pedersen, Oluf Borbye, Wang, J. & Nielsen, Rasmus, 2010, In: Genetic Epidemiology. 34, 5, p. 479-491 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Detecting host responses to microbial stimulation using primary epithelial organoids

    Lange, Jette Bornholdt, Müller, C. V., Nielsen, M. J., Strickertsson, J., Rago, D., Chen, Y., Maciag, Grzegorz Jerzy, Skov, Jonathan, Wellejus, A., Schweiger, P. J., Hansen, Stine Lind, Broholm, C., Gögenur, Ismail, Maimets, Martti, Sloth, S., Hendel, J., Baker, A., Sandelin, Albin Gustav & Jensen, Kim Bak, 2023, In: Gut Microbes. 15, 2, 16 p., 2281012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Detecting selection in low-coverage high-throughput sequencing data using principal component analysis

    Meisner, Jonas, Albrechtsen, Anders & Hanghøj, Kristian Ebbesen, 2021, In: BMC Bioinformatics. 22, 13 p., 470.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Detecting sequence signals in targeting peptides using deep learning

    Almagro Armenteros, J. J., Salvatore, Marco, Emanuelsson, O., Winther, Ole, von Heijne, G., Elofsson, A. & Nielsen, H., 2019, In: Life Science Alliance. 2, 5, 14 p., 201900429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Detection of Active Matriptase using a Biotinylated Chloromethyl Ketone Peptide

    Godiksen, S., Soendergaard, C., Friis, S., Jensen, J. K., Lange, Jette Bornholdt, Sales, K. U., Huang, M., Bugge, T. H. & Vogel, Lotte, 2013, In: P L o S One. 8, 10, 10 p., e77146.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Detection of Viable and Total Bacterial Community in the Pit Mud of Chinese Strong-Flavor Liquor Using Propidium Monoazide Combined With Quantitative PCR and 16S rRNA Gene Sequencing

    Tan, G., Zhou, R., Zhang, W., Hu, Y., Ruan, Z., Li, J., Zhang, C., Shen, D., Peng, N., Liang, Y. & Zhao, S., 2020, In: Frontiers in Microbiology. 11, 9 p., 896.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing

    Enroth, Christel Hougård, Poulsen, L. D., Iversen, S., Kirpekar, F., Albrechtsen, Anders & Vinther, Jeppe, 2019, In: Nucleic Acids Research. 47, 20, 13 p., e126.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Detection of reverse transcriptase termination sites using cDNA ligation and massive parallel sequencing

    Kielpinski, L. J., Boyd, M., Sandelin, Albin Gustav & Vinther, Jeppe, 2013, In: Methods in molecular biology (Clifton, N.J.). 1038, p. 213-31 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Detection of slicer activity by immunopurified plant ARGONAUTE1

    Arribas Hernandez, Laura, Vigh, Maria Louisa & Brodersen, Peter, 2019, Plant MicroRNAs: Methods and Protocols. Folter, S. D. (ed.). Humana Press, p. 295-316 22 p. (Methods in Molecular Biology, Vol. 1932).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  40. Published

    Determinants of enhancer and promoter activities of regulatory elements

    Andersson, Robin & Sandelin, Albin Gustav, 2020, In: Nature Reviews Genetics. 21, 2, p. 71-87 17 p.

    Research output: Contribution to journal › Review › Research › peer-review

  41. Published

    Development and Optimization of a Silica Column-Based Extraction Protocol for Ancient DNA

    Dehasque, M., Chrzanová Pecnerová, Patrícia, Kempe Lagerholm, V., Ersmark, E., Danilov, G. K., Mortensen, P., Vartanyan, S. & Dalén, L., 2022, In: Genes. 13, 4, 16 p., 687.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Diabetes in population isolates: lessons from Greenland

    Grarup, Niels, Moltke, Ida, Albrechtsen, Anders & Hansen, Torben, 2015, In: The Review of Diabetic Studies. 12, 3-4, p. 320-329 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  43. Published

    Differential expression of cellular microRNAs in HPV 11, -16, and -45 transfected cells

    Dreher, A., Rossing, M., Kaczkowski, B., Andersen, D. K., Larsen, T. J., Christophersen, M. K., Nielsen, Finn Cilius & Norrild, B., 2011, In: Biochemical and Biophysical Research Communications. 412, 1, p. 20-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR

    Dreher, A., Rossing, M., Kaczkowski, B., Nielsen, Finn Cilius & Norrild, B., 17 Dec 2010, In: Biochemical and Biophysical Research Communications. 403, 3-4, p. 357-62 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Differential gene expression in the otic capsule and the middle ear-an annotation of bone-related signaling genes

    Nielsen, M. C., Martin-Bertelsen, T., Friis, M., Winther, Ole, Friis-Hansen, Lennart Jan, Rye-Jørgensen, N., Bloch, S. & Sørensen, Mads Sølvsten, 2015, In: Otology & Neurotology. 36, 4, p. 727-732 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    DiscoTope-3.0: improved B-cell epitope prediction using inverse folding latent representations

    Høie, M. H., Gade, F. S., Johansen, J., Würtzen, C., Winther, Ole, Nielsen, M. & Marcatili, P., 2024, In: Frontiers in Immunology. 15, 12 p., 1322712.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Discovering novel hydrolases from hot environments

    Wohlgemuth, R., Littlechild, J., Monti, D., Schnorr, K., van Rossum, T., Siebers, B., Menzel, P., Kublanov, I. V., Rike, A. G., Skretas, G., Szabo, Z., Peng, Xu & Young, M. J., 2018, In: Biotechnology Advances. 36, 8, p. 2077-2100

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

    Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J. A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-Ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-Sueki, H., Frith, M. C., Abugessaisa, I., Aitken, S. & 31 others, Aken, B. L., Alam, I., Alam, T., Alasiri, R., Alhendi, A. M. N., Alinejad-Rokny, H., Alvarez, M. J., Andersson, Robin, Arakawa, T., Araki, M., Arbel, T., Lange, Jette Bornholdt, Boyd, M., Chen, Y., Coskun, M., Dalby, M., Ienasescu, H., Jørgensen, M., Kaczkowski, B., Kere, J., Li, K., Lilje, B., Nepal, C., Nguyen, Q. H., Nielsen, L. K., Rennie, Sarah, Sandelin, Albin Gustav, Valen, E., Vitezic, M., Vitting-Seerup, K. & FANTOM Consortium, F. C., 2021, In: Nature Communications. 12, 18 p., 3297.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Discovery, genotyping and characterization of structural variation and novel sequence at single nucleotide resolution from de novo genome assemblies on a population scale

    Danish Pan Genome Consortium, D. P. G. C., Belling, K. G. & Rasmussen, Simon, 2015, In: GigaScience. 4, 13 p., 64.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Discrete structural dynamics of pseudo-palindromic motifs control DNA binding of bacterial toxin-antitoxin complexes

    Brodersen, D. E., Bendtsen, K. L., Xu, K., Luckmann, M., Winther, K. S., Shah, S. A. & Pedersen, C. N. S., 2017, In: F A S E B Journal. 31, S1, 1 p., 777.2.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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