A single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization

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  • Ruihua Zhang
  • Shanshan Pan
  • Yingying Zhang
  • Yating Qin
  • Xiao Du
  • Zengbao Yuan
  • Yongrui Lu
  • Yue Song
  • Mengqi Zhang
  • Nannan Zhang
  • Jie Ma
  • Zhe Zhang
  • Xiaodong Jia
  • Kun Wang
  • Shunping He
  • Shanshan Liu
  • Ming Ni
  • Xin Liu
  • Xun Xu
  • Huanming Yang
  • Jian Wang
  • Inge Seim
  • Guangyi Fan
The six species of lungfish possess both lungs and gills and are the closest extant relatives of tetrapods. Here, we report a single-cell transcriptome atlas of the West African lungfish (Protopterus annectens). This species manifests the most extreme form of terrestrialization, a life history strategy to survive dry periods that can last for years, characterized by dormancy and reversible adaptive changes of the gills and lungs. Our atlas highlights the cell type diversity of the West African lungfish, including gene expression consistent with phenotype changes of terrestrialization. Comparison with terrestrial tetrapods and ray-finned fishes reveals broad homology between the swim bladder and lung cell types as well as shared and idiosyncratic changes of the external gills of the West African lungfish and the internal gills of Atlantic salmon. The single-cell atlas presented here provides a valuable resource for further exploration of the respiratory system evolution in vertebrates and the diversity of lungfish terrestrialization.
OriginalsprogEngelsk
Artikelnummer5630
TidsskriftNature Communications
Vol/bind14
Udgave nummer1
Antal sider15
ISSN2041-1723
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
This work was supported by a grant from The General Program (Key Program, Major Research Plan) of National Natural Science Foundation of China (No. 32170439, to G.Y.F.), the major scientific and technological projects of Hainan Province (ZDKJ2019011), the Specially-appointed Professor Program of Jiangsu Province (to I.S.), the Jiangsu Foreign Expert Bureau (to I.S.), and the Jiangsu Provincial Department of Technology (grant JSSCTD202142 to I.S.). This work was also supported by the Guangdong Provincial Key Laboratory of Genome Read and Write (No. 2017B030301011). We thank the China National Gene Bank for the sequencing data archiving and storage.

Funding Information:
This work was supported by a grant from The General Program (Key Program, Major Research Plan) of National Natural Science Foundation of China (No. 32170439, to G.Y.F.), the major scientific and technological projects of Hainan Province (ZDKJ2019011), the Specially-appointed Professor Program of Jiangsu Province (to I.S.), the Jiangsu Foreign Expert Bureau (to I.S.), and the Jiangsu Provincial Department of Technology (grant JSSCTD202142 to I.S.). This work was also supported by the Guangdong Provincial Key Laboratory of Genome Read and Write (No. 2017B030301011). We thank the China National Gene Bank for the sequencing data archiving and storage.

Publisher Copyright:
© 2023, Springer Nature Limited.

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