Adjusting for unmeasured confounding using validation data: simplified two-stage calibration for survival and dichotomous outcomes
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Adjusting for unmeasured confounding using validation data : simplified two-stage calibration for survival and dichotomous outcomes. / Hjellvik, Vidar; De Bruin, Marie L; Samuelsen, Sven O; Karlstad, Øystein; Andersen, Morten; Haukka, Jari; Vestergaard, Peter; de Vries, Frank; Furu, Kari.
I: Statistics in Medicine, Bind 38, Nr. 15, 2019, s. 2719-2734.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Adjusting for unmeasured confounding using validation data
T2 - simplified two-stage calibration for survival and dichotomous outcomes
AU - Hjellvik, Vidar
AU - De Bruin, Marie L
AU - Samuelsen, Sven O
AU - Karlstad, Øystein
AU - Andersen, Morten
AU - Haukka, Jari
AU - Vestergaard, Peter
AU - de Vries, Frank
AU - Furu, Kari
N1 - © 2019 John Wiley & Sons, Ltd.
PY - 2019
Y1 - 2019
N2 - In epidemiology, one typically wants to estimate the risk of an outcome associated with an exposure after adjusting for confounders. Sometimes, outcome and exposure and maybe some confounders are available in a large data set, whereas some important confounders are only available in a validation data set that is typically a subset of the main data set. A generally applicable method in this situation is the two-stage calibration (TSC) method. We present a simplified easy-to-implement version of the TSC for the case where the validation data are a subset of the main data. We compared the simplified version to the standard TSC version for incidence rate ratios, odds ratios, relative risks, and hazard ratios using simulated data, and the simplified version performed better than our implementation of the standard version. The simplified version was also tested on real data and performed well.
AB - In epidemiology, one typically wants to estimate the risk of an outcome associated with an exposure after adjusting for confounders. Sometimes, outcome and exposure and maybe some confounders are available in a large data set, whereas some important confounders are only available in a validation data set that is typically a subset of the main data set. A generally applicable method in this situation is the two-stage calibration (TSC) method. We present a simplified easy-to-implement version of the TSC for the case where the validation data are a subset of the main data. We compared the simplified version to the standard TSC version for incidence rate ratios, odds ratios, relative risks, and hazard ratios using simulated data, and the simplified version performed better than our implementation of the standard version. The simplified version was also tested on real data and performed well.
U2 - 10.1002/sim.8131
DO - 10.1002/sim.8131
M3 - Journal article
C2 - 30828842
VL - 38
SP - 2719
EP - 2734
JO - Statistics in Medicine
JF - Statistics in Medicine
SN - 0277-6715
IS - 15
ER -
ID: 214447230