Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China. / Cai, Yudong; Fu, Weiwei; Cai, Dawei; Heller, Rasmus; Zheng, Zhuqing; Wen, Jia; Li, Hui; Wang, Xiaolong; Alshawi, Akil; Sun, Zhouyong; Zhu, Siqi; Wang, Juan; Yang, Miaomiao; Hu, Songmei; Li, Yan; Yang, Zhirui; Gong, Mian; Hou, Yunan; Lan, Tianming; Wu, Kui; Chen, Yulin; Jiang, Yu; Wang, Xihong.
I: Molecular Biology and Evolution, Bind 37, Nr. 7, 2020, s. 2099-2109.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China
AU - Cai, Yudong
AU - Fu, Weiwei
AU - Cai, Dawei
AU - Heller, Rasmus
AU - Zheng, Zhuqing
AU - Wen, Jia
AU - Li, Hui
AU - Wang, Xiaolong
AU - Alshawi, Akil
AU - Sun, Zhouyong
AU - Zhu, Siqi
AU - Wang, Juan
AU - Yang, Miaomiao
AU - Hu, Songmei
AU - Li, Yan
AU - Yang, Zhirui
AU - Gong, Mian
AU - Hou, Yunan
AU - Lan, Tianming
AU - Wu, Kui
AU - Chen, Yulin
AU - Jiang, Yu
AU - Wang, Xihong
PY - 2020
Y1 - 2020
N2 - Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats.
AB - Goats are one of the most widespread farmed animals across the world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from the Late Neolithic period to the Iron Age. We found close genetic affinities between ancient and modern Chinese goats, demonstrating their genetic continuity. We found that Chinese goats originated from the eastern regions around the Fertile Crescent, and we estimated that the ancestors of Chinese goats diverged from this population in the Chalcolithic period. Modern Chinese goats were divided into a northern and a southern group, coinciding with the most prominent climatic division in China, and two genes related to hair follicle development, FGF5 and EDA2R, were highly divergent between these populations. We identified a likely causal de novo deletion near FGF5 in northern Chinese goats that increased to high frequency over time, whereas EDA2R harbored standing variation dating to the Neolithic. Our findings add to our understanding of the genetic composition and local evolutionary process of Chinese goats.
KW - EDA2R
KW - FGF5
KW - adaptation
KW - ancient DNA
KW - Chinese goats
KW - population genomics
U2 - 10.1093/molbev/msaa103
DO - 10.1093/molbev/msaa103
M3 - Journal article
C2 - 32324877
AN - SCOPUS:85086792826
VL - 37
SP - 2099
EP - 2109
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
SN - 0737-4038
IS - 7
ER -
ID: 244236451