Calculation of accurate small angle X-ray scattering curves from coarse-grained protein models
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Genome sequencing projects have expanded the gap between the amount of known protein sequences and structures. The limitations of current high resolution structure determination methods make it unlikely that this gap will disappear in the near future. Small angle X-ray scattering (SAXS) is an established low resolution method for routinely determining the structure of proteins in solution. The purpose of this study is to develop a method for the efficient calculation of accurate SAXS curves from coarse-grained protein models. Such a method can for example be used to construct a likelihood function, which is paramount for structure determination based on statistical inference.
Originalsprog | Engelsk |
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Tidsskrift | B M C Bioinformatics |
Vol/bind | 11 |
Sider (fra-til) | 429 |
ISSN | 1471-2105 |
DOI | |
Status | Udgivet - 1 jan. 2010 |
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