Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7

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Standard

Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7. / Murphy, Kenan C.; Ritchie, Jennifer M.; Waldor, Matthew K.; Løbner-Olesen, Anders; Marinus, M. G.

I: Journal of Bacteriology, Bind 190, Nr. 1, 2008, s. 438-441.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Murphy, KC, Ritchie, JM, Waldor, MK, Løbner-Olesen, A & Marinus, MG 2008, 'Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7', Journal of Bacteriology, bind 190, nr. 1, s. 438-441. https://doi.org/10.1128/JB.01373-07

APA

Murphy, K. C., Ritchie, J. M., Waldor, M. K., Løbner-Olesen, A., & Marinus, M. G. (2008). Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7. Journal of Bacteriology, 190(1), 438-441. https://doi.org/10.1128/JB.01373-07

Vancouver

Murphy KC, Ritchie JM, Waldor MK, Løbner-Olesen A, Marinus MG. Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7. Journal of Bacteriology. 2008;190(1):438-441. https://doi.org/10.1128/JB.01373-07

Author

Murphy, Kenan C. ; Ritchie, Jennifer M. ; Waldor, Matthew K. ; Løbner-Olesen, Anders ; Marinus, M. G. / Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7. I: Journal of Bacteriology. 2008 ; Bind 190, Nr. 1. s. 438-441.

Bibtex

@article{15888fdc33434f05aaf786f04229dc6e,
title = "Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7",
abstract = "Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production, and here, we provide evidence that Dam methyltransferase is essential for maintenance of 933W lysogeny. Our findings are consistent with the idea that the 933W prophage has a relatively low threshold for induction, which may promote Stx2 production during infection.",
keywords = "Coliphages/enzymology, Enterohemorrhagic Escherichia coli/drug effects, Kanamycin/pharmacology, Lysogeny, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Shiga Toxin 2/genetics, Site-Specific DNA-Methyltransferase (Adenine-Specific)/genetics, Virulence",
author = "Murphy, {Kenan C.} and Ritchie, {Jennifer M.} and Waldor, {Matthew K.} and Anders L{\o}bner-Olesen and Marinus, {M. G.}",
year = "2008",
doi = "10.1128/JB.01373-07",
language = "English",
volume = "190",
pages = "438--441",
journal = "Journal of Bacteriology",
issn = "0021-9193",
publisher = "American Society for Microbiology",
number = "1",

}

RIS

TY - JOUR

T1 - Dam Methyltransferase Is Required for Stable Lysogeny of the Shiga Toxin (Stx2)-Encoding Bacteriophage 933W of Enterohemorrhagic Escherichia coli O157:H7

AU - Murphy, Kenan C.

AU - Ritchie, Jennifer M.

AU - Waldor, Matthew K.

AU - Løbner-Olesen, Anders

AU - Marinus, M. G.

PY - 2008

Y1 - 2008

N2 - Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production, and here, we provide evidence that Dam methyltransferase is essential for maintenance of 933W lysogeny. Our findings are consistent with the idea that the 933W prophage has a relatively low threshold for induction, which may promote Stx2 production during infection.

AB - Shiga toxin 2 (Stx2), one of the principal virulence factors of enterohemorrhagic Escherichia coli, is encoded by 933W, a lambda-like prophage. 933W prophage induction contributes to Stx2 production, and here, we provide evidence that Dam methyltransferase is essential for maintenance of 933W lysogeny. Our findings are consistent with the idea that the 933W prophage has a relatively low threshold for induction, which may promote Stx2 production during infection.

KW - Coliphages/enzymology

KW - Enterohemorrhagic Escherichia coli/drug effects

KW - Kanamycin/pharmacology

KW - Lysogeny

KW - Oligonucleotide Array Sequence Analysis

KW - Polymerase Chain Reaction

KW - Shiga Toxin 2/genetics

KW - Site-Specific DNA-Methyltransferase (Adenine-Specific)/genetics

KW - Virulence

U2 - 10.1128/JB.01373-07

DO - 10.1128/JB.01373-07

M3 - Journal article

C2 - 17981979

VL - 190

SP - 438

EP - 441

JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

IS - 1

ER -

ID: 200971713