Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Drosophila TNF/TNFRs : At the crossroad between metabolism, immunity, and tissue homeostasis. / Colombani, Julien; Andersen, Ditte S.
I: FEBS Letters, Bind 597, Nr. 19, 2023, s. 2416-2432.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Drosophila TNF/TNFRs
T2 - At the crossroad between metabolism, immunity, and tissue homeostasis
AU - Colombani, Julien
AU - Andersen, Ditte S.
N1 - Publisher Copyright: © 2023 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
PY - 2023
Y1 - 2023
N2 - Tumor necrosis factor (TNF)-α is a highly conserved proinflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF-TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF-mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contribute to its antitumor and tumor-promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity- and cancer-associated metabolic diseases have provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.
AB - Tumor necrosis factor (TNF)-α is a highly conserved proinflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF-TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF-mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contribute to its antitumor and tumor-promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity- and cancer-associated metabolic diseases have provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.
KW - Drosophila
KW - immunity
KW - metabolism
KW - TNF
KW - tumor
U2 - 10.1002/1873-3468.14716
DO - 10.1002/1873-3468.14716
M3 - Review
C2 - 37567762
AN - SCOPUS:85168875221
VL - 597
SP - 2416
EP - 2432
JO - F E B S Letters
JF - F E B S Letters
SN - 0014-5793
IS - 19
ER -
ID: 366645857