Four new genera encompassing six new species are described in the Lyophyllaceae (Agaricales): the monotypic Australocybe from Australia; the monotypic Phaeotephrocybe from Belize; the monotypic Nigrocarnea from Laos containing the novel conidia-producing species N. radicata and Praearthromyces containing two Asian taxa, the conidia-producing P. corneri known from Malaysia and Singapore and P. griseus from Thailand, which lacks conidial production. In addition, we describe Arthromyces glabriceps, which is the first species in the genus Arthromyces that lacks conidial production on the basidiome. Alternative options for a classification of these lyophylloid taxa are discussed and based on morphological, ecological and biogeographical considerations rejected.