HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6

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Standard

HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6. / Ødum, Niels; Milman, N; Jakobsen, B K; Georgsen, J; Svejgaard, A.

I: Experimental and Clinical Immunogenetics, Bind 8, Nr. 4, 1991, s. 227-32.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ødum, N, Milman, N, Jakobsen, BK, Georgsen, J & Svejgaard, A 1991, 'HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6', Experimental and Clinical Immunogenetics, bind 8, nr. 4, s. 227-32.

APA

Ødum, N., Milman, N., Jakobsen, B. K., Georgsen, J., & Svejgaard, A. (1991). HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6. Experimental and Clinical Immunogenetics, 8(4), 227-32.

Vancouver

Ødum N, Milman N, Jakobsen BK, Georgsen J, Svejgaard A. HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6. Experimental and Clinical Immunogenetics. 1991;8(4):227-32.

Author

Ødum, Niels ; Milman, N ; Jakobsen, B K ; Georgsen, J ; Svejgaard, A. / HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6. I: Experimental and Clinical Immunogenetics. 1991 ; Bind 8, Nr. 4. s. 227-32.

Bibtex

@article{d0877450fd9711ddb219000ea68e967b,
title = "HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6",
abstract = "The distribution of HLA class II (DR, DQ, and DP) antigens was studied in 41 patients with symptomatic sarcoidosis (SA) and ethnically matched healthy controls. HLA-DR, -DQw1 and -DQw3 typings were performed with alloantisera in the conventional microcytotoxic test, whereas -DP typings were done using primed lymphocyte typing. The frequencies of DRw6 were 41.5% in SA patients and 17.9% in controls (relative risk, RR = 3.2, p = 0.00087, p less than 0.05 when corrected). DR3 was decreased to 14.6% in SA patients compared to 25.9% in controls (RR = 0.49, p = 0.07, i.e., not statistically significant). The decreased frequency of DR3 was only seen in patients with severe, long-standing disease. In contrast, the DRw6 increase was most pronounced in patients with severe disease (RR = 6.4; p = 0.003). There were no statistically significant deviations in the frequencies of DQ and DP alleles between patients and controls. In conclusion, our data suggest that DRW6 confers susceptibility and DR3 resistance to severe, long-standing disease.",
author = "Niels {\O}dum and N Milman and Jakobsen, {B K} and J Georgsen and A Svejgaard",
note = "Keywords: Female; Gene Frequency; HLA-D Antigens; HLA-DP Antigens; HLA-DQ Antigens; HLA-DR Antigens; HLA-DR3 Antigen; HLA-DR6 Antigen; Humans; Linkage (Genetics); Male; Sarcoidosis",
year = "1991",
language = "English",
volume = "8",
pages = "227--32",
journal = "Experimental and Clinical Immunogenetics",
issn = "0254-9670",
publisher = "S Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6

AU - Ødum, Niels

AU - Milman, N

AU - Jakobsen, B K

AU - Georgsen, J

AU - Svejgaard, A

N1 - Keywords: Female; Gene Frequency; HLA-D Antigens; HLA-DP Antigens; HLA-DQ Antigens; HLA-DR Antigens; HLA-DR3 Antigen; HLA-DR6 Antigen; Humans; Linkage (Genetics); Male; Sarcoidosis

PY - 1991

Y1 - 1991

N2 - The distribution of HLA class II (DR, DQ, and DP) antigens was studied in 41 patients with symptomatic sarcoidosis (SA) and ethnically matched healthy controls. HLA-DR, -DQw1 and -DQw3 typings were performed with alloantisera in the conventional microcytotoxic test, whereas -DP typings were done using primed lymphocyte typing. The frequencies of DRw6 were 41.5% in SA patients and 17.9% in controls (relative risk, RR = 3.2, p = 0.00087, p less than 0.05 when corrected). DR3 was decreased to 14.6% in SA patients compared to 25.9% in controls (RR = 0.49, p = 0.07, i.e., not statistically significant). The decreased frequency of DR3 was only seen in patients with severe, long-standing disease. In contrast, the DRw6 increase was most pronounced in patients with severe disease (RR = 6.4; p = 0.003). There were no statistically significant deviations in the frequencies of DQ and DP alleles between patients and controls. In conclusion, our data suggest that DRW6 confers susceptibility and DR3 resistance to severe, long-standing disease.

AB - The distribution of HLA class II (DR, DQ, and DP) antigens was studied in 41 patients with symptomatic sarcoidosis (SA) and ethnically matched healthy controls. HLA-DR, -DQw1 and -DQw3 typings were performed with alloantisera in the conventional microcytotoxic test, whereas -DP typings were done using primed lymphocyte typing. The frequencies of DRw6 were 41.5% in SA patients and 17.9% in controls (relative risk, RR = 3.2, p = 0.00087, p less than 0.05 when corrected). DR3 was decreased to 14.6% in SA patients compared to 25.9% in controls (RR = 0.49, p = 0.07, i.e., not statistically significant). The decreased frequency of DR3 was only seen in patients with severe, long-standing disease. In contrast, the DRw6 increase was most pronounced in patients with severe disease (RR = 6.4; p = 0.003). There were no statistically significant deviations in the frequencies of DQ and DP alleles between patients and controls. In conclusion, our data suggest that DRW6 confers susceptibility and DR3 resistance to severe, long-standing disease.

M3 - Journal article

C2 - 1817566

VL - 8

SP - 227

EP - 232

JO - Experimental and Clinical Immunogenetics

JF - Experimental and Clinical Immunogenetics

SN - 0254-9670

IS - 4

ER -

ID: 10636505