Infant airway microbiota and topical immune perturbations in the origins of childhood asthma
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Infant airway microbiota and topical immune perturbations in the origins of childhood asthma. / Thorsen, Jonathan; Rasmussen, Morten A.; Waage, Johannes; Mortensen, Martin; Brejnrod, Asker; Bønnelykke, Klaus; Chawes, Bo L.; Brix, Susanne; Sørensen, Søren J.; Stokholm, Jakob; Bisgaard, Hans.
I: Nature Communications, Bind 10, 5001, 2019.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Infant airway microbiota and topical immune perturbations in the origins of childhood asthma
AU - Thorsen, Jonathan
AU - Rasmussen, Morten A.
AU - Waage, Johannes
AU - Mortensen, Martin
AU - Brejnrod, Asker
AU - Bønnelykke, Klaus
AU - Chawes, Bo L.
AU - Brix, Susanne
AU - Sørensen, Søren J.
AU - Stokholm, Jakob
AU - Bisgaard, Hans
PY - 2019
Y1 - 2019
N2 - Asthma is believed to arise through early life aberrant immune development in response to environmental exposures that may influence the airway microbiota. Here, we examine the airway microbiota during the first three months of life by 16S rRNA gene amplicon sequencing in the population-based Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort consisting of 700 children monitored for the development of asthma since birth. Microbial diversity and the relative abundances of Veillonella and Prevotella in the airways at age one month are associated with asthma by age 6 years, both individually and with additional taxa in a multivariable model. Higher relative abundance of these bacteria is furthermore associated with an airway immune profile dominated by reduced TNF-α and IL-1β and increased CCL2 and CCL17, which itself is an independent predictor for asthma. These findings suggest a mechanism of microbiota-immune interactions in early infancy that predisposes to childhood asthma.
AB - Asthma is believed to arise through early life aberrant immune development in response to environmental exposures that may influence the airway microbiota. Here, we examine the airway microbiota during the first three months of life by 16S rRNA gene amplicon sequencing in the population-based Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort consisting of 700 children monitored for the development of asthma since birth. Microbial diversity and the relative abundances of Veillonella and Prevotella in the airways at age one month are associated with asthma by age 6 years, both individually and with additional taxa in a multivariable model. Higher relative abundance of these bacteria is furthermore associated with an airway immune profile dominated by reduced TNF-α and IL-1β and increased CCL2 and CCL17, which itself is an independent predictor for asthma. These findings suggest a mechanism of microbiota-immune interactions in early infancy that predisposes to childhood asthma.
U2 - 10.1038/s41467-019-12989-7
DO - 10.1038/s41467-019-12989-7
M3 - Journal article
C2 - 31676759
AN - SCOPUS:85074341820
VL - 10
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 5001
ER -
ID: 230095079