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Large-scale association analyses identify host factors influencing human gut microbiome composition. / Kurilshikov, Alexander; Medina-Gomez, Carolina; Bacigalupe, Rodrigo; Radjabzadeh, Djawad; Wang, Jun; Demirkan, Ayse; Le Roy, Caroline I.; Raygoza Garay, Juan Antonio; Finnicum, Casey T.; Liu, Xingrong; Zhernakova, Daria V.; Bonder, Marc Jan; Hansen, Tue H.; Frost, Fabian; Rühlemann, Malte C.; Turpin, Williams; Moon, Jee Young; Kim, Han Na; Lüll, Kreete; Barkan, Elad; Shah, Shiraz A.; Fornage, Myriam; Szopinska-Tokov, Joanna; Wallen, Zachary D.; Borisevich, Dmitrii; Agreus, Lars; Andreasson, Anna; Bang, Corinna; Bedrani, Larbi; Bell, Jordana T.; Bisgaard, Hans; Boehnke, Michael; Boomsma, Dorret I.; Burk, Robert D.; Claringbould, Annique; Croitoru, Kenneth; Davies, Gareth E.; van Duijn, Cornelia M.; Duijts, Liesbeth; Falony, Gwen; Fu, Jingyuan; van der Graaf, Adriaan; Hansen, Torben; Homuth, Georg; Hughes, David A.; Ijzerman, Richard G.; Jackson, Matthew A.; Jaddoe, Vincent W.V.; Joossens, Marie; Jørgensen, Torben; Keszthelyi, Daniel; Knight, Rob; Laakso, Markku; Laudes, Matthias; Launer, Lenore J.; Lieb, Wolfgang; Lusis, Aldons J.; Masclee, Ad A.M.; Moll, Henriette A.; Mujagic, Zlatan; Qibin, Qi; Rothschild, Daphna; Shin, Hocheol; Sørensen, Søren J.; Steves, Claire J.; Thorsen, Jonathan; Timpson, Nicholas J.; Tito, Raul Y.; Vieira-Silva, Sara; Völker, Uwe; Völzke, Henry; Võsa, Urmo; Wade, Kaitlin H.; Walter, Susanna; Watanabe, Kyoko; Weiss, Stefan; Weiss, Frank U.; Weissbrod, Omer; Westra, Harm Jan; Willemsen, Gonneke; Payami, Haydeh; Jonkers, Daisy M.A.E.; Arias Vasquez, Alejandro; de Geus, Eco J.C.; Meyer, Katie A.; Stokholm, Jakob; Segal, Eran; Org, Elin; Wijmenga, Cisca; Kim, Hyung Lae; Kaplan, Robert C.; Spector, Tim D.; Uitterlinden, Andre G.; Rivadeneira, Fernando; Franke, Andre; Lerch, Markus M.; Franke, Lude; Sanna, Serena; D’Amato, Mauro; Pedersen, Oluf; Paterson, Andrew D.; Kraaij, Robert; Raes, Jeroen; Zhernakova, Alexandra.
I:
Nature Genetics, Bind 53, 2021, s. 156-165.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Kurilshikov, A, Medina-Gomez, C, Bacigalupe, R, Radjabzadeh, D, Wang, J, Demirkan, A, Le Roy, CI, Raygoza Garay, JA, Finnicum, CT, Liu, X, Zhernakova, DV, Bonder, MJ, Hansen, TH, Frost, F, Rühlemann, MC, Turpin, W, Moon, JY, Kim, HN, Lüll, K, Barkan, E, Shah, SA, Fornage, M, Szopinska-Tokov, J, Wallen, ZD, Borisevich, D, Agreus, L, Andreasson, A, Bang, C, Bedrani, L, Bell, JT, Bisgaard, H, Boehnke, M, Boomsma, DI, Burk, RD, Claringbould, A, Croitoru, K, Davies, GE, van Duijn, CM, Duijts, L, Falony, G, Fu, J, van der Graaf, A
, Hansen, T, Homuth, G, Hughes, DA, Ijzerman, RG, Jackson, MA, Jaddoe, VWV, Joossens, M, Jørgensen, T, Keszthelyi, D, Knight, R, Laakso, M, Laudes, M, Launer, LJ, Lieb, W, Lusis, AJ, Masclee, AAM, Moll, HA, Mujagic, Z, Qibin, Q, Rothschild, D, Shin, H
, Sørensen, SJ, Steves, CJ
, Thorsen, J, Timpson, NJ, Tito, RY, Vieira-Silva, S, Völker, U, Völzke, H, Võsa, U, Wade, KH, Walter, S, Watanabe, K, Weiss, S, Weiss, FU, Weissbrod, O, Westra, HJ, Willemsen, G, Payami, H, Jonkers, DMAE, Arias Vasquez, A, de Geus, EJC, Meyer, KA
, Stokholm, J, Segal, E, Org, E, Wijmenga, C, Kim, HL, Kaplan, RC, Spector, TD, Uitterlinden, AG, Rivadeneira, F, Franke, A, Lerch, MM, Franke, L, Sanna, S, D’Amato, M
, Pedersen, O, Paterson, AD, Kraaij, R, Raes, J & Zhernakova, A 2021, '
Large-scale association analyses identify host factors influencing human gut microbiome composition',
Nature Genetics, bind 53, s. 156-165.
https://doi.org/10.1038/s41588-020-00763-1APA
Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay, J. A., Finnicum, C. T., Liu, X., Zhernakova, D. V., Bonder, M. J., Hansen, T. H., Frost, F., Rühlemann, M. C., Turpin, W., Moon, J. Y., Kim, H. N., Lüll, K., ... Zhernakova, A. (2021).
Large-scale association analyses identify host factors influencing human gut microbiome composition.
Nature Genetics,
53, 156-165.
https://doi.org/10.1038/s41588-020-00763-1Vancouver
Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A o.a.
Large-scale association analyses identify host factors influencing human gut microbiome composition.
Nature Genetics. 2021;53:156-165.
https://doi.org/10.1038/s41588-020-00763-1Author
Kurilshikov, Alexander ; Medina-Gomez, Carolina ; Bacigalupe, Rodrigo ; Radjabzadeh, Djawad ; Wang, Jun ; Demirkan, Ayse ; Le Roy, Caroline I. ; Raygoza Garay, Juan Antonio ; Finnicum, Casey T. ; Liu, Xingrong ; Zhernakova, Daria V. ; Bonder, Marc Jan ; Hansen, Tue H. ; Frost, Fabian ; Rühlemann, Malte C. ; Turpin, Williams ; Moon, Jee Young ; Kim, Han Na ; Lüll, Kreete ; Barkan, Elad ; Shah, Shiraz A. ; Fornage, Myriam ; Szopinska-Tokov, Joanna ; Wallen, Zachary D. ; Borisevich, Dmitrii ; Agreus, Lars ; Andreasson, Anna ; Bang, Corinna ; Bedrani, Larbi ; Bell, Jordana T. ; Bisgaard, Hans ; Boehnke, Michael ; Boomsma, Dorret I. ; Burk, Robert D. ; Claringbould, Annique ; Croitoru, Kenneth ; Davies, Gareth E. ; van Duijn, Cornelia M. ; Duijts, Liesbeth ; Falony, Gwen ; Fu, Jingyuan ; van der Graaf, Adriaan ; Hansen, Torben ; Homuth, Georg ; Hughes, David A. ; Ijzerman, Richard G. ; Jackson, Matthew A. ; Jaddoe, Vincent W.V. ; Joossens, Marie ; Jørgensen, Torben ; Keszthelyi, Daniel ; Knight, Rob ; Laakso, Markku ; Laudes, Matthias ; Launer, Lenore J. ; Lieb, Wolfgang ; Lusis, Aldons J. ; Masclee, Ad A.M. ; Moll, Henriette A. ; Mujagic, Zlatan ; Qibin, Qi ; Rothschild, Daphna ; Shin, Hocheol ; Sørensen, Søren J. ; Steves, Claire J. ; Thorsen, Jonathan ; Timpson, Nicholas J. ; Tito, Raul Y. ; Vieira-Silva, Sara ; Völker, Uwe ; Völzke, Henry ; Võsa, Urmo ; Wade, Kaitlin H. ; Walter, Susanna ; Watanabe, Kyoko ; Weiss, Stefan ; Weiss, Frank U. ; Weissbrod, Omer ; Westra, Harm Jan ; Willemsen, Gonneke ; Payami, Haydeh ; Jonkers, Daisy M.A.E. ; Arias Vasquez, Alejandro ; de Geus, Eco J.C. ; Meyer, Katie A. ; Stokholm, Jakob ; Segal, Eran ; Org, Elin ; Wijmenga, Cisca ; Kim, Hyung Lae ; Kaplan, Robert C. ; Spector, Tim D. ; Uitterlinden, Andre G. ; Rivadeneira, Fernando ; Franke, Andre ; Lerch, Markus M. ; Franke, Lude ; Sanna, Serena ; D’Amato, Mauro ; Pedersen, Oluf ; Paterson, Andrew D. ; Kraaij, Robert ; Raes, Jeroen ; Zhernakova, Alexandra. / Large-scale association analyses identify host factors influencing human gut microbiome composition. I: Nature Genetics. 2021 ; Bind 53. s. 156-165.
Bibtex
@article{6e59e7efb68047e1ad066d2bc2d67581,
title = "Large-scale association analyses identify host factors influencing human gut microbiome composition",
abstract = "To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10−8) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 × 10−20), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 × 10−10 < P < 5 × 10−8) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.",
author = "Alexander Kurilshikov and Carolina Medina-Gomez and Rodrigo Bacigalupe and Djawad Radjabzadeh and Jun Wang and Ayse Demirkan and {Le Roy}, {Caroline I.} and {Raygoza Garay}, {Juan Antonio} and Finnicum, {Casey T.} and Xingrong Liu and Zhernakova, {Daria V.} and Bonder, {Marc Jan} and Hansen, {Tue H.} and Fabian Frost and R{\"u}hlemann, {Malte C.} and Williams Turpin and Moon, {Jee Young} and Kim, {Han Na} and Kreete L{\"u}ll and Elad Barkan and Shah, {Shiraz A.} and Myriam Fornage and Joanna Szopinska-Tokov and Wallen, {Zachary D.} and Dmitrii Borisevich and Lars Agreus and Anna Andreasson and Corinna Bang and Larbi Bedrani and Bell, {Jordana T.} and Hans Bisgaard and Michael Boehnke and Boomsma, {Dorret I.} and Burk, {Robert D.} and Annique Claringbould and Kenneth Croitoru and Davies, {Gareth E.} and {van Duijn}, {Cornelia M.} and Liesbeth Duijts and Gwen Falony and Jingyuan Fu and {van der Graaf}, Adriaan and Torben Hansen and Georg Homuth and Hughes, {David A.} and Ijzerman, {Richard G.} and Jackson, {Matthew A.} and Jaddoe, {Vincent W.V.} and Marie Joossens and Torben J{\o}rgensen and Daniel Keszthelyi and Rob Knight and Markku Laakso and Matthias Laudes and Launer, {Lenore J.} and Wolfgang Lieb and Lusis, {Aldons J.} and Masclee, {Ad A.M.} and Moll, {Henriette A.} and Zlatan Mujagic and Qi Qibin and Daphna Rothschild and Hocheol Shin and S{\o}rensen, {S{\o}ren J.} and Steves, {Claire J.} and Jonathan Thorsen and Timpson, {Nicholas J.} and Tito, {Raul Y.} and Sara Vieira-Silva and Uwe V{\"o}lker and Henry V{\"o}lzke and Urmo V{\~o}sa and Wade, {Kaitlin H.} and Susanna Walter and Kyoko Watanabe and Stefan Weiss and Weiss, {Frank U.} and Omer Weissbrod and Westra, {Harm Jan} and Gonneke Willemsen and Haydeh Payami and Jonkers, {Daisy M.A.E.} and {Arias Vasquez}, Alejandro and {de Geus}, {Eco J.C.} and Meyer, {Katie A.} and Jakob Stokholm and Eran Segal and Elin Org and Cisca Wijmenga and Kim, {Hyung Lae} and Kaplan, {Robert C.} and Spector, {Tim D.} and Uitterlinden, {Andre G.} and Fernando Rivadeneira and Andre Franke and Lerch, {Markus M.} and Lude Franke and Serena Sanna and Mauro D{\textquoteright}Amato and Oluf Pedersen and Paterson, {Andrew D.} and Robert Kraaij and Jeroen Raes and Alexandra Zhernakova",
year = "2021",
doi = "10.1038/s41588-020-00763-1",
language = "English",
volume = "53",
pages = "156--165",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Large-scale association analyses identify host factors influencing human gut microbiome composition
AU - Kurilshikov, Alexander
AU - Medina-Gomez, Carolina
AU - Bacigalupe, Rodrigo
AU - Radjabzadeh, Djawad
AU - Wang, Jun
AU - Demirkan, Ayse
AU - Le Roy, Caroline I.
AU - Raygoza Garay, Juan Antonio
AU - Finnicum, Casey T.
AU - Liu, Xingrong
AU - Zhernakova, Daria V.
AU - Bonder, Marc Jan
AU - Hansen, Tue H.
AU - Frost, Fabian
AU - Rühlemann, Malte C.
AU - Turpin, Williams
AU - Moon, Jee Young
AU - Kim, Han Na
AU - Lüll, Kreete
AU - Barkan, Elad
AU - Shah, Shiraz A.
AU - Fornage, Myriam
AU - Szopinska-Tokov, Joanna
AU - Wallen, Zachary D.
AU - Borisevich, Dmitrii
AU - Agreus, Lars
AU - Andreasson, Anna
AU - Bang, Corinna
AU - Bedrani, Larbi
AU - Bell, Jordana T.
AU - Bisgaard, Hans
AU - Boehnke, Michael
AU - Boomsma, Dorret I.
AU - Burk, Robert D.
AU - Claringbould, Annique
AU - Croitoru, Kenneth
AU - Davies, Gareth E.
AU - van Duijn, Cornelia M.
AU - Duijts, Liesbeth
AU - Falony, Gwen
AU - Fu, Jingyuan
AU - van der Graaf, Adriaan
AU - Hansen, Torben
AU - Homuth, Georg
AU - Hughes, David A.
AU - Ijzerman, Richard G.
AU - Jackson, Matthew A.
AU - Jaddoe, Vincent W.V.
AU - Joossens, Marie
AU - Jørgensen, Torben
AU - Keszthelyi, Daniel
AU - Knight, Rob
AU - Laakso, Markku
AU - Laudes, Matthias
AU - Launer, Lenore J.
AU - Lieb, Wolfgang
AU - Lusis, Aldons J.
AU - Masclee, Ad A.M.
AU - Moll, Henriette A.
AU - Mujagic, Zlatan
AU - Qibin, Qi
AU - Rothschild, Daphna
AU - Shin, Hocheol
AU - Sørensen, Søren J.
AU - Steves, Claire J.
AU - Thorsen, Jonathan
AU - Timpson, Nicholas J.
AU - Tito, Raul Y.
AU - Vieira-Silva, Sara
AU - Völker, Uwe
AU - Völzke, Henry
AU - Võsa, Urmo
AU - Wade, Kaitlin H.
AU - Walter, Susanna
AU - Watanabe, Kyoko
AU - Weiss, Stefan
AU - Weiss, Frank U.
AU - Weissbrod, Omer
AU - Westra, Harm Jan
AU - Willemsen, Gonneke
AU - Payami, Haydeh
AU - Jonkers, Daisy M.A.E.
AU - Arias Vasquez, Alejandro
AU - de Geus, Eco J.C.
AU - Meyer, Katie A.
AU - Stokholm, Jakob
AU - Segal, Eran
AU - Org, Elin
AU - Wijmenga, Cisca
AU - Kim, Hyung Lae
AU - Kaplan, Robert C.
AU - Spector, Tim D.
AU - Uitterlinden, Andre G.
AU - Rivadeneira, Fernando
AU - Franke, Andre
AU - Lerch, Markus M.
AU - Franke, Lude
AU - Sanna, Serena
AU - D’Amato, Mauro
AU - Pedersen, Oluf
AU - Paterson, Andrew D.
AU - Kraaij, Robert
AU - Raes, Jeroen
AU - Zhernakova, Alexandra
PY - 2021
Y1 - 2021
N2 - To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10−8) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 × 10−20), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 × 10−10 < P < 5 × 10−8) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.
AB - To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10−8) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 × 10−20), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 × 10−10 < P < 5 × 10−8) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.
U2 - 10.1038/s41588-020-00763-1
DO - 10.1038/s41588-020-00763-1
M3 - Journal article
C2 - 33462485
AN - SCOPUS:85100210047
VL - 53
SP - 156
EP - 165
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -
