Metagenome-wide association of gut microbiome features for schizophrenia
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Metagenome-wide association of gut microbiome features for schizophrenia. / Zhu, Feng; Ju, Yanmei; Wang, Wei; Wang, Qi; Guo, Ruijin; Ma, Qingyan; Sun, Qiang; Fan, Yajuan; Xie, Yuying; Yang, Zai; Jie, Zhuye; Zhao, Binbin; Xiao, Liang; Yang, Lin; Zhang, Tao; Feng, Junqin; Guo, Liyang; He, Xiaoyan; Chen, Yunchun; Chen, Ce; Gao, Chengge; Xu, Xun; Yang, Huanming; Wang, Jian; Dang, Yonghui; Madsen, Lise; Brix, Susanne; Kristiansen, Karsten; Jia, Huijue; Ma, Xiancang.
I: Nature Communications, Bind 11, 1612, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Metagenome-wide association of gut microbiome features for schizophrenia
AU - Zhu, Feng
AU - Ju, Yanmei
AU - Wang, Wei
AU - Wang, Qi
AU - Guo, Ruijin
AU - Ma, Qingyan
AU - Sun, Qiang
AU - Fan, Yajuan
AU - Xie, Yuying
AU - Yang, Zai
AU - Jie, Zhuye
AU - Zhao, Binbin
AU - Xiao, Liang
AU - Yang, Lin
AU - Zhang, Tao
AU - Feng, Junqin
AU - Guo, Liyang
AU - He, Xiaoyan
AU - Chen, Yunchun
AU - Chen, Ce
AU - Gao, Chengge
AU - Xu, Xun
AU - Yang, Huanming
AU - Wang, Jian
AU - Dang, Yonghui
AU - Madsen, Lise
AU - Brix, Susanne
AU - Kristiansen, Karsten
AU - Jia, Huijue
AU - Ma, Xiancang
PY - 2020
Y1 - 2020
N2 - Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.
AB - Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of the complex interaction between the gut microbiota and the brain. Here we explore the fecal microbiome based on 90 medication-free schizophrenia patients and 81 controls and identify a microbial species classifier distinguishing patients from controls with an area under the receiver operating characteristic curve (AUC) of 0.896, and replicate the microbiome-based disease classifier in 45 patients and 45 controls (AUC = 0.765). Functional potentials associated with schizophrenia include differences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neurotransmitters. Transplantation of a schizophrenia-enriched bacterium, Streptococcus vestibularis, appear to induces deficits in social behaviors, and alters neurotransmitter levels in peripheral tissues in recipient mice. Our findings provide new leads for further investigations in cohort studies and animal models.
U2 - 10.1038/s41467-020-15457-9
DO - 10.1038/s41467-020-15457-9
M3 - Journal article
C2 - 32235826
AN - SCOPUS:85082791457
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 1612
ER -
ID: 239955767