Mind the gap
Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt
Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small a-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.
Originalsprog | Engelsk |
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Tidsskrift | Structure |
Vol/bind | 31 |
Udgave nummer | 6 |
Sider (fra-til) | 641-643 |
Antal sider | 3 |
ISSN | 0969-2126 |
DOI |
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Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Financial support by the Lundbeck Foundation and Novo Nordisk Foundation is gratefully acknowledged.
Publisher Copyright:
© 2023 Elsevier Ltd
ID: 360336254