Modeling transfer of vaginal microbiota from mother to infant in early life
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Modeling transfer of vaginal microbiota from mother to infant in early life. / Mortensen, Martin Steen; Rasmussen, Morten Arendt; Stokholm, Jakob; Brejnrod, Asker Daniel; Balle, Christina; Thorsen, Jonathan; Krogfelt, Karen Angeliki; Bisgaard, Hans; Sørensen, Søren Johannes.
I: eLife, Bind 10, e57051, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Modeling transfer of vaginal microbiota from mother to infant in early life
AU - Mortensen, Martin Steen
AU - Rasmussen, Morten Arendt
AU - Stokholm, Jakob
AU - Brejnrod, Asker Daniel
AU - Balle, Christina
AU - Thorsen, Jonathan
AU - Krogfelt, Karen Angeliki
AU - Bisgaard, Hans
AU - Sørensen, Søren Johannes
PY - 2021
Y1 - 2021
N2 - Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota’s role in seeding the child’s microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother–child dyads from the COPSAC2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children’s fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.
AB - Early-life microbiota has been linked to the development of chronic inflammatory diseases. It has been hypothesized that maternal vaginal microbiota is an important initial seeding source and therefore might have lifelong effects on disease risk. To understand maternal vaginal microbiota’s role in seeding the child’s microbiota and the extent of delivery mode-dependent transmission, we studied 665 mother–child dyads from the COPSAC2010 cohort. The maternal vaginal microbiota was evaluated twice in the third trimester and compared with the children’s fecal (at 1 week, 1 month, and 1 year of age) and airway microbiota (at 1 week, 1 month, and 3 months). Based on the concept of weighted transfer ratios (WTRs), we have identified bacterial orders for which the WTR displays patterns indicate persistent or transient transfer from the maternal vaginal microbiome, as well as orders that are shared at later time points independent of delivery mode, indicating a common reservoir.
U2 - 10.7554/ELIFE.57051
DO - 10.7554/ELIFE.57051
M3 - Journal article
C2 - 33448927
AN - SCOPUS:85100010042
VL - 10
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e57051
ER -
ID: 257324135