PIRD: Pan Immune Repertoire Database
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PIRD : Pan Immune Repertoire Database. / Zhang, Wei; Wang, Longlong; Liu, Ke; Wei, Xiaofeng; Yang, Kai; Du, Wensi; Wang, Shiyu; Guo, Nannan; Ma, Chuanchuan; Luo, Lihua; Wu, Jinghua; Lin, Liya; Yang, Fan; Gao, Fei; Wang, Xie; Li, Tao; Zhang, Ruifang; Saksena, Nitin K.; Yang, Huanming; Wang, Jian; Fang, Lin; Hou, Yong; Xu, Xun; Liu, Xiao.
I: Bioinformatics, Bind 36, Nr. 3, 2020, s. 897-903.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - PIRD
T2 - Pan Immune Repertoire Database
AU - Zhang, Wei
AU - Wang, Longlong
AU - Liu, Ke
AU - Wei, Xiaofeng
AU - Yang, Kai
AU - Du, Wensi
AU - Wang, Shiyu
AU - Guo, Nannan
AU - Ma, Chuanchuan
AU - Luo, Lihua
AU - Wu, Jinghua
AU - Lin, Liya
AU - Yang, Fan
AU - Gao, Fei
AU - Wang, Xie
AU - Li, Tao
AU - Zhang, Ruifang
AU - Saksena, Nitin K.
AU - Yang, Huanming
AU - Wang, Jian
AU - Fang, Lin
AU - Hou, Yong
AU - Xu, Xun
AU - Liu, Xiao
PY - 2020
Y1 - 2020
N2 - MOTIVATION: T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external and internal antigens. Understanding these receptors is critical for exploring the process of immunoreaction and exploiting potential applications in immunotherapy and antibody drug design. Although a large number of samples have had their TCR and BCR repertoires sequenced using high-throughput sequencing in recent years, very few databases have been constructed to store these kinds of data. To resolve this issue, we developed a database. RESULTS: We developed a database, the Pan Immune Repertoire Database (PIRD), located in China National GeneBank (CNGBdb), to collect and store annotated TCR and BCR sequencing data, including from Homo sapiens and other species. In addition to data storage, PIRD also provides functions of data visualization and interactive online analysis. Additionally, a manually curated database of TCRs and BCRs targeting known antigens (TBAdb) was also deposited in PIRD. AVAILABILITY AND IMPLEMENTATION: PIRD can be freely accessed at https://db.cngb.org/pird.
AB - MOTIVATION: T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external and internal antigens. Understanding these receptors is critical for exploring the process of immunoreaction and exploiting potential applications in immunotherapy and antibody drug design. Although a large number of samples have had their TCR and BCR repertoires sequenced using high-throughput sequencing in recent years, very few databases have been constructed to store these kinds of data. To resolve this issue, we developed a database. RESULTS: We developed a database, the Pan Immune Repertoire Database (PIRD), located in China National GeneBank (CNGBdb), to collect and store annotated TCR and BCR sequencing data, including from Homo sapiens and other species. In addition to data storage, PIRD also provides functions of data visualization and interactive online analysis. Additionally, a manually curated database of TCRs and BCRs targeting known antigens (TBAdb) was also deposited in PIRD. AVAILABILITY AND IMPLEMENTATION: PIRD can be freely accessed at https://db.cngb.org/pird.
U2 - 10.1093/bioinformatics/btz614
DO - 10.1093/bioinformatics/btz614
M3 - Journal article
C2 - 31373607
AN - SCOPUS:85079077505
VL - 36
SP - 897
EP - 903
JO - Computer Applications in the Biosciences
JF - Computer Applications in the Biosciences
SN - 1471-2105
IS - 3
ER -
ID: 238003194