Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture

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Standard

Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture. / Pedersen, P. S.; Brandt, N. J.; Larsen, E. H.

I: IRCS Medical Science, Bind 14, Nr. 7, 1986, s. 701-702.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Pedersen, PS, Brandt, NJ & Larsen, EH 1986, 'Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture', IRCS Medical Science, bind 14, nr. 7, s. 701-702.

APA

Pedersen, P. S., Brandt, N. J., & Larsen, E. H. (1986). Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture. IRCS Medical Science, 14(7), 701-702.

Vancouver

Pedersen PS, Brandt NJ, Larsen EH. Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture. IRCS Medical Science. 1986;14(7):701-702.

Author

Pedersen, P. S. ; Brandt, N. J. ; Larsen, E. H. / Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture. I: IRCS Medical Science. 1986 ; Bind 14, Nr. 7. s. 701-702.

Bibtex

@article{e1c92274df7043c29129d0bbdfb0c22f,
title = "Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture",
abstract = "Confluent human epithelial cell cultures derived from the reabsorptive sweat duct have proven to be a stable experimental model with basic electrophysiological properties identical with the native organ, when grown on a permeable support and mounted in an Ussing chamber. Using these techniques, the effect on electrical parameters of isoproterenol stimulation was studied on cultures from normals and patients with cystic fibrosis. The responses to isoproterenol of the two groups differed entirely in nature. In normals the transepithelial resistance decreased because of increased chloride conductance without engaging active transport processes. In patients the opposite situation was observed. The results indicate a defect localized in the intracellular transformation of the isoproterenol stimulus in cystic fibrosis.",
author = "Pedersen, {P. S.} and Brandt, {N. J.} and Larsen, {E. H.}",
year = "1986",
language = "English",
volume = "14",
pages = "701--702",
journal = "IRCS Medical Science",
issn = "0305-6651",
publisher = "MTP International Research Communications ltd.",
number = "7",

}

RIS

TY - JOUR

T1 - Qualitatively abnormal beta-adrenergic response in cystic fibrosis sweat duct cell culture

AU - Pedersen, P. S.

AU - Brandt, N. J.

AU - Larsen, E. H.

PY - 1986

Y1 - 1986

N2 - Confluent human epithelial cell cultures derived from the reabsorptive sweat duct have proven to be a stable experimental model with basic electrophysiological properties identical with the native organ, when grown on a permeable support and mounted in an Ussing chamber. Using these techniques, the effect on electrical parameters of isoproterenol stimulation was studied on cultures from normals and patients with cystic fibrosis. The responses to isoproterenol of the two groups differed entirely in nature. In normals the transepithelial resistance decreased because of increased chloride conductance without engaging active transport processes. In patients the opposite situation was observed. The results indicate a defect localized in the intracellular transformation of the isoproterenol stimulus in cystic fibrosis.

AB - Confluent human epithelial cell cultures derived from the reabsorptive sweat duct have proven to be a stable experimental model with basic electrophysiological properties identical with the native organ, when grown on a permeable support and mounted in an Ussing chamber. Using these techniques, the effect on electrical parameters of isoproterenol stimulation was studied on cultures from normals and patients with cystic fibrosis. The responses to isoproterenol of the two groups differed entirely in nature. In normals the transepithelial resistance decreased because of increased chloride conductance without engaging active transport processes. In patients the opposite situation was observed. The results indicate a defect localized in the intracellular transformation of the isoproterenol stimulus in cystic fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=0022452765&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0022452765

VL - 14

SP - 701

EP - 702

JO - IRCS Medical Science

JF - IRCS Medical Science

SN - 0305-6651

IS - 7

ER -

ID: 367300791