Reduced chromatin accessibility correlates with resistance to Notch activation

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Standard

Reduced chromatin accessibility correlates with resistance to Notch activation. / van den Ameele, Jelle; Krautz, Robert; Cheetham, Seth W.; Donovan, Alex P.A.; Llorà-Batlle, Oriol; Yakob, Rebecca; Brand, Andrea H.

I: Nature Communications, Bind 13, Nr. 1, 2210, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

van den Ameele, J, Krautz, R, Cheetham, SW, Donovan, APA, Llorà-Batlle, O, Yakob, R & Brand, AH 2022, 'Reduced chromatin accessibility correlates with resistance to Notch activation', Nature Communications, bind 13, nr. 1, 2210. https://doi.org/10.1038/s41467-022-29834-z

APA

van den Ameele, J., Krautz, R., Cheetham, S. W., Donovan, A. P. A., Llorà-Batlle, O., Yakob, R., & Brand, A. H. (2022). Reduced chromatin accessibility correlates with resistance to Notch activation. Nature Communications, 13(1), [2210]. https://doi.org/10.1038/s41467-022-29834-z

Vancouver

van den Ameele J, Krautz R, Cheetham SW, Donovan APA, Llorà-Batlle O, Yakob R o.a. Reduced chromatin accessibility correlates with resistance to Notch activation. Nature Communications. 2022;13(1). 2210. https://doi.org/10.1038/s41467-022-29834-z

Author

van den Ameele, Jelle ; Krautz, Robert ; Cheetham, Seth W. ; Donovan, Alex P.A. ; Llorà-Batlle, Oriol ; Yakob, Rebecca ; Brand, Andrea H. / Reduced chromatin accessibility correlates with resistance to Notch activation. I: Nature Communications. 2022 ; Bind 13, Nr. 1.

Bibtex

@article{7fc11537a60a4716a7d2d62f9d3df281,
title = "Reduced chromatin accessibility correlates with resistance to Notch activation",
abstract = "The Notch signalling pathway is a master regulator of cell fate transitions in development and disease. In the brain, Notch promotes neural stem cell (NSC) proliferation, regulates neuronal migration and maturation and can act as an oncogene or tumour suppressor. How NOTCH and its transcription factor RBPJ activate distinct gene regulatory networks in closely related cell types in vivo remains to be determined. Here we use Targeted DamID (TaDa), requiring only thousands of cells, to identify NOTCH and RBPJ binding in NSCs and their progeny in the mouse embryonic cerebral cortex in vivo. We find that NOTCH and RBPJ associate with a broad network of NSC genes. Repression of NSC-specific Notch target genes in intermediate progenitors and neurons correlates with decreased chromatin accessibility, suggesting that chromatin compaction may contribute to restricting NOTCH-mediated transactivation.",
author = "{van den Ameele}, Jelle and Robert Krautz and Cheetham, {Seth W.} and Donovan, {Alex P.A.} and Oriol Llor{\`a}-Batlle and Rebecca Yakob and Brand, {Andrea H.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s41467-022-29834-z",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Reduced chromatin accessibility correlates with resistance to Notch activation

AU - van den Ameele, Jelle

AU - Krautz, Robert

AU - Cheetham, Seth W.

AU - Donovan, Alex P.A.

AU - Llorà-Batlle, Oriol

AU - Yakob, Rebecca

AU - Brand, Andrea H.

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - The Notch signalling pathway is a master regulator of cell fate transitions in development and disease. In the brain, Notch promotes neural stem cell (NSC) proliferation, regulates neuronal migration and maturation and can act as an oncogene or tumour suppressor. How NOTCH and its transcription factor RBPJ activate distinct gene regulatory networks in closely related cell types in vivo remains to be determined. Here we use Targeted DamID (TaDa), requiring only thousands of cells, to identify NOTCH and RBPJ binding in NSCs and their progeny in the mouse embryonic cerebral cortex in vivo. We find that NOTCH and RBPJ associate with a broad network of NSC genes. Repression of NSC-specific Notch target genes in intermediate progenitors and neurons correlates with decreased chromatin accessibility, suggesting that chromatin compaction may contribute to restricting NOTCH-mediated transactivation.

AB - The Notch signalling pathway is a master regulator of cell fate transitions in development and disease. In the brain, Notch promotes neural stem cell (NSC) proliferation, regulates neuronal migration and maturation and can act as an oncogene or tumour suppressor. How NOTCH and its transcription factor RBPJ activate distinct gene regulatory networks in closely related cell types in vivo remains to be determined. Here we use Targeted DamID (TaDa), requiring only thousands of cells, to identify NOTCH and RBPJ binding in NSCs and their progeny in the mouse embryonic cerebral cortex in vivo. We find that NOTCH and RBPJ associate with a broad network of NSC genes. Repression of NSC-specific Notch target genes in intermediate progenitors and neurons correlates with decreased chromatin accessibility, suggesting that chromatin compaction may contribute to restricting NOTCH-mediated transactivation.

U2 - 10.1038/s41467-022-29834-z

DO - 10.1038/s41467-022-29834-z

M3 - Journal article

C2 - 35468895

AN - SCOPUS:85128838109

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 2210

ER -

ID: 330385969