TCR down-regulation controls virus-specific CD8+ T cell responses
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The CD3γ di-leucine-based motif plays a central role in TCR down-regulation. However, little is understood about the role of the CD3γ di-leucine-based motif in physiological T cell responses. In this study, we show that the expansion in numbers of virus-specific CD8+ T cells is impaired in mice with a mutated CD3γ di-leucine-based motif. The CD3γ mutation did not impair early TCR signaling, nor did it compromise recruitment or proliferation of virus-specific T cells, but it increased the apoptosis rate of the activated T cells by increasing down-regulation of the antiapoptotic molecule Bcl-2. This resulted in a 2-fold reduction in the clonal expansion of virus-specific CD8+ T cells during the acute phase of vesicular stomatitis virus and lymphocytic choriomeningitis virus infections. These results identify an important role of CD3γ-mediated TCR down-regulation in virus-specific CD8+ T cell responses.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Immunology |
Vol/bind | 181 |
Udgave nummer | 11 |
Sider (fra-til) | 7786-7799 |
Antal sider | 14 |
ISSN | 0022-1767 |
Status | Udgivet - 1 dec. 2009 |
ID: 199119634