The gut microbiome in atherosclerotic cardiovascular disease
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The gut microbiome in atherosclerotic cardiovascular disease. / Jie, Zhuye; Xia, Huihua; Zhong, Shi-Long; Feng, Qiang; Li, Shenghui; Liang, Suisha; Zhong, Huanzi; Liu, Zhipeng; Gao, Yuan; Zhao, Hui; Zhang, Dongya; Su, Zheng; Fang, Zhiwei; Lan, Zhou; Li, Junhua; Xiao, Liang; Li, Jun; Li, Ruijun; Li, Xiaoping; Li, Fei; Ren, Huahui; Huang, Yan; Peng, Yangqing; Li, Guanglei; Wen, Bo; Dong, Bo; Chen, Ji-Yan; Geng, Qing-Shan; Zhang, Zhi-Wei; Yang, Huanming; Wang, Jian; Wang, Jun; Zhang, Xuan; Madsen, Lise; Brix, Susanne; Ning, Guang; Xu, Xun; Liu, Xin; Hou, Yong; Jia, Huijue; He, Kunlun; Kristiansen, Karsten.
I: Nature Communications, Bind 8, Nr. 1, 845, 10.10.2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The gut microbiome in atherosclerotic cardiovascular disease
AU - Jie, Zhuye
AU - Xia, Huihua
AU - Zhong, Shi-Long
AU - Feng, Qiang
AU - Li, Shenghui
AU - Liang, Suisha
AU - Zhong, Huanzi
AU - Liu, Zhipeng
AU - Gao, Yuan
AU - Zhao, Hui
AU - Zhang, Dongya
AU - Su, Zheng
AU - Fang, Zhiwei
AU - Lan, Zhou
AU - Li, Junhua
AU - Xiao, Liang
AU - Li, Jun
AU - Li, Ruijun
AU - Li, Xiaoping
AU - Li, Fei
AU - Ren, Huahui
AU - Huang, Yan
AU - Peng, Yangqing
AU - Li, Guanglei
AU - Wen, Bo
AU - Dong, Bo
AU - Chen, Ji-Yan
AU - Geng, Qing-Shan
AU - Zhang, Zhi-Wei
AU - Yang, Huanming
AU - Wang, Jian
AU - Wang, Jun
AU - Zhang, Xuan
AU - Madsen, Lise
AU - Brix, Susanne
AU - Ning, Guang
AU - Xu, Xun
AU - Liu, Xin
AU - Hou, Yong
AU - Jia, Huijue
AU - He, Kunlun
AU - Kristiansen, Karsten
PY - 2017/10/10
Y1 - 2017/10/10
N2 - The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.
AB - The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.
UR - http://www.scopus.com/inward/record.url?scp=85031012310&partnerID=8YFLogxK
U2 - 10.1038/s41467-017-00900-1
DO - 10.1038/s41467-017-00900-1
M3 - Journal article
C2 - 29018189
AN - SCOPUS:85031012310
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 845
ER -
ID: 185407779