The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
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Dokumenter
- The Interplay between Dysregulated Ion Transport and Mitochondrial Architecture as a Dangerous Liaison in Cancer
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Transport of ions and nutrients is a core mitochondrial function, without which there would be no mitochondrial metabolism and ATP production. Both ion homeostasis and mitochon-drial phenotype undergo pervasive changes during cancer development, and both play key roles in driving the malignancy. However, the link between these events has been largely ignored. This review comprehensively summarizes and critically discusses the role of the reciprocal relationship between ion transport and mitochondria in crucial cellular functions, including metabolism, signal-ing, and cell fate decisions. We focus on Ca2+, H+, and K+, which play essential and highly intercon-nected roles in mitochondrial function and are profoundly dysregulated in cancer. We describe the transport and roles of these ions in normal mitochondria, summarize the changes occurring during cancer development, and discuss how they might impact tumorigenesis.
Originalsprog | Engelsk |
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Artikelnummer | 5209 |
Tidsskrift | International Journal of Molecular Sciences |
Vol/bind | 22 |
Udgave nummer | 10 |
Antal sider | 27 |
ISSN | 1661-6596 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
Work in our laboratories on this topic is supported by the European Union (H2020?MSCA? ITN?2018, grant 813834 (LAP, SFP), the Danish Cancer Society (R269?A15823, SFP), the Novo Nordisk Foundation (NNF19OC0057739, SFP), and the Max?Planck Society. We are grateful to members of our labs for valuable discussions in the process.
Funding Information:
Funding: Work in our laboratories on this topic is supported by the European Union (H2020‐MSCA‐ ITN‐2018, grant 813834 (LAP, SFP), the Danish Cancer Society (R269‐A15823, SFP), the Novo Nordisk Foundation (NNF19OC0057739, SFP), and the Max‐Planck Society.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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