Vitamin D controls T cell antigen receptor signaling and activation of human T cells
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Vitamin D controls T cell antigen receptor signaling and activation of human T cells. / von Essen, Marina Rode; Kongsbak-Wismann, Martin; Schjerling, Peter; Ølgaard, Klaus; Ødum, Niels; Geisler, Carsten.
I: Nature Immunology, Bind 11, Nr. 4, 2010, s. 344-349.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Vitamin D controls T cell antigen receptor signaling and activation of human T cells
AU - von Essen, Marina Rode
AU - Kongsbak-Wismann, Martin
AU - Schjerling, Peter
AU - Ølgaard, Klaus
AU - Ødum, Niels
AU - Geisler, Carsten
N1 - Keywords: Cells, Cultured; Enzyme Activation; Humans; Immunoblotting; In Situ Hybridization; Lymphocyte Activation; Phospholipase C gamma; Receptors, Antigen, T-Cell; Receptors, Calcitriol; Signal Transduction; Vitamin D
PY - 2010
Y1 - 2010
N2 - Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.
AB - Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of approximately 75-fold in PLC-gamma1 expression, which correlated with greater TCR responsiveness. Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR). Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway. Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-gamma1, which are required for subsequent classical TCR signaling and T cell activation.
U2 - 10.1038/ni.1851
DO - 10.1038/ni.1851
M3 - Journal article
C2 - 20208539
VL - 11
SP - 344
EP - 349
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 4
ER -
ID: 20172279